主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (9): 777-782.doi: 10.3969/j.issn.1006-2157.2017.09.012

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Influence of heat-clearing dampness-resolving stasis-dispelling therapy on JAK/STAT signaling pathway mediated by Leptin in patients with chronic renal failure-damp-heat pattern*

WANG Dong, WANG Yiping#, YU Min, HU Shunjin, LYU Yong, CHENG Wan, LIU Jiasheng, WEI Ling, JIN Hua   

  1. First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Anhui 230031, China
  • Received:2017-04-10 Online:2017-09-10 Published:2017-09-10
  • Supported by:
    National Natural Science Foundation of China (No. 81473673, No. 81403372), Natural Science Foundation of Anhui Province (No. 1508085MH198)

Abstract: Objective To observe the influences of Qingshen (Kidney-Clearing) Granules, with effects of clearing heat, resolving dampness and dispelling stasis, on expressions of Janus-activated kinase 2 (JAK2) and signal transducers and activator of transcriptions 3 (STAT3) in Janus-activated kinase-signaltransducer and activator of transcription (JAK/STAT) signaling pathway mediated by Leptin in patients with chronic renal failure (CRF)-damp-heat pattern, and investigate the mechanism of Qingshen Granules in treatment of CRF. Methods The patients with CRF-damp-heat pattern (n=68) were randomly divided into treatment group and control group (each n=34). The study was completed actually in 60 patients, and 29 in treatment group and 31 in control group. All 2 groups were given basic treatment of Western medicine, and treatment group was additionally given Qingshen Granules (thrice daily and 1 bas every time) for 12 weeks. The clinical efficacy and changes of serum creatinine (SCr), estimated glomerular filtration rate (eGFR), serum Leptin, JAK2 and STAT3 were observed in 2 groups. Results The clinical efficacy was 86.21% (25/29) and total effective rate of TCM patterns was 82.76% (24/29) in treatment group, and 58.06% (18/31) and 54.84% (17/31) in control group (P<0.05). After treatment, the level of SCr decreased significantly (P<0.01) and level of GFR increased significantly (P<0.01) in treatment group compared with those before treatment, which were superior to those in control group at the same term (P<0.05). After treatment, the level of Leptin, and expressions of JAK2 and STAT3 decreased significantly (P<0.01) in treatment group compared with those before treatment, which were superior to those in control group at the same term (P<0.05 or P<0.01). Conclusion Qingshen Granules can reduce the level of Leptin and expressions of JAK2 and STAT3, inhibit the activation of JAK/STAT signaling pathway mediated by Leptin, relieve clinical symptoms and improve kidney function in patients with CRF-damp-heat pattern.

Key words: chronic renal failure, damp-heat pattern, heat-clearing dampness-resolving stasis-dispelling therapy, Qingshen (Kidney-Clearing) Granules, serum Leptin, Janus-activated kinase 2, signal transducers and activator of transcriptions 3

CLC Number: 

  • R269.25