主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (11): 940-945.doi: 10.3969/j.issn.1006-2157.2017.11.012

• Orignal Article • Previous Articles     Next Articles

Influence of Bugan Jianyao Fang (Liver-tonifying Lumbar-invigorating Decoction) on expressions of MMP-3 and TIMP-1 in rats with lumbar disc degeneration*

QIU Xiangzhong1, LIU Dong2, ZHANG Xincheng1, TAN Xuyi1, TANG Hao1, JIANG Shengchang1   

  1. 1 Affiliated Hospital of Hunan Academy of Chinese Medical Sciences, Hunan 410006, China;
    2 Chinese Medicine Hospital of Xiangtan City, Hunan 411104, China
  • Received:2017-06-12 Online:2017-11-10 Published:2017-11-10
  • Supported by:
    Key project of Hunan province traditional Chinese medicine research (No.201710),Hunan natural science foundation project(No.2017JJ2170),Key project of Hunan province traditional Chinese medicine research (No.201507),project of Hunan education department scientific research (No.14C0865),Key project of Hunan academy of Chinese medical science (No.201503)

Abstract: Objective To observe the influence of Bugan Jianyao Fang (Liver-tonifying Lumbar-invigorating Decoction) on expressions of intervertebral disc matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in rats with lumbar disc degeneration. Methods SD rats (n=75) were randomly divided into sham-operation group, model group, Yaobitong (Waist Impediment-Freeing Capsules) group, doxycycline (DOX) group and Bugan Jianyao Fang group (each n=15). After establishing successfully the model of lumbar disc degeneration in rats, all groups were, respectively, given orally Yaobitong, DOX and Bugan Jianyao Fang. The expressions of intervertebral disc MMP-3 and TIMP-1 were detected in all group after and 20 d and 4 d after intervention. Results After intervention for 20 d and 40 d, the expressions of intervertebral disc MMP-3 and TIMP-1 decreased in Yaobitong group, DOX group and Bugan Jianyao Fang group compared with model group (P<0.05). The difference in expressions of intervertebral disc MMP-3 and TIMP-1 had statistical significance in Yaobitong group, DOX group and Bugan Jianyao Fang group after intervention compared with those in the same groups before intervention (P<0.05). The comparison among Bugan Jianyao Fang group, Yaobitong group and DOX group showed that the difference had no statistical significance (P>0.05) at all time points. Conclusion Bugan Jianyao Fang can reduce the expressions of intervertebral disc MMP-3 and TIMP-1 in rats with lumbar disc degeneration, which may be one of mechanisms of Bugan Jianyao Fang preventing and curing lumbar disc degeneration.

Key words: Bugan Jianyao Fang (Liver-tonifying Lumbar-invigorating Decoction), intervertebral disc, degeneration, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-1, rats

CLC Number: 

  • R285.5