主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2018, Vol. 41 ›› Issue (3): 242-247.doi: 10.3969/j.issn.1006-2157.2018.03.011

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Correlation between waist hip ratio and carotid atherosclerosis in women aged over 40 with high risk of stroke and study on TCM pattern manifestations*

Wei Jingjing1, Zhang Zhichen2, Shen Wei1, Jin Xianglan2, Zhang Yunling3#   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China;
    3 Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
  • Received:2017-09-14 Online:2018-03-30 Published:2018-03-30
  • Supported by:
    *National Stroke High Risk Population Screening and Intervention, TCM Scientific Research (No. 201407001-8)

Abstract: Objective To investigate the correlation between waist hip ratio (WHR) and carotid atherosclerosis and TCM pattern manifestations in women aged over 40 with high risk of stroke. Methods The perimenopausal population with high risk of stroke (n=629) was chosen and divided, according to quartile of WHR, into 4 groups, and general clinical data and incidence of carotid atherosclerosis were compared among 4 groups. Taken group I as reference, risk of occurring carotid atherosclerosis was analyzed in other 3 group. The correlation between WHR and incidence of carotid atherosclerosis was studied by using binary Logistic regression analysis. Meanwhile, the population was divided into menopausal group and non-menopausal group, and WHR, incidence of carotid atherosclerosis, TCM symptoms and features of tongue and pulse were compared between 2 groups. Results The indexes of age, family history of stroke, menopausal cases, body mass index (BMI), overweight cases, triglyceride (TG) and high-density lipoprotein (HDL) had significant difference among 4 groups (P<0.05). The incidence of carotid atherosclerosis increased successively in 4 groups and difference had statistical significance (P<0.01). Compared with group I, risk of occurring carotid atherosclerosis was by 1.348 times, 1.927 times and 2.305 times in other 3 groups (P<0.01). WHR was correlated to incidence of carotid atherosclerosis after controlled other variables (P<0.01). WHR was higher (P<0.05) and incidence of carotid atherosclerosis increased significantly (P<0.01) in menopausal group compared with non-menopausal group. The TCM pattern manifestations of qi deficiency, yin deficiency, yang deficiency and blood stasis were significantly more in menopausal group than those in non-menopausal group (P<0.05 or P<0.01). The pattern identification of viscera and bowels involved liver, spleen and kidney, and disease nature showed deficiency complicated by excessiveness and deficiency was the basis. Conclusion The risk of carotid atherosclerosis will be higher when WHR increases in women aged over 40 with high risk of stroke. WHR can be taken as an indicator of carotid atherosclerosis. The treatment with TCM is based on pattern identification of liver, spleen and kidney, and disease nature shows deficiency complicated by excessiveness and deficiency is the basis.

Key words: population with high risk of stroke, female, waist hip ratio, carotid atherosclerosis, TCM pattern manifestations

CLC Number: 

  • R271.11+6