主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2018, Vol. 41 ›› Issue (5): 423-427.doi: 10.3969/j.issn.1006-2157.2018.05.012

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Influence of Chinese medicinals with functions of activating blood and removing toxicity on inflammatory markers and blood fat in patients with acute coronary syndrome after percutaneous coronary intervention*

Guo Ming, Gao Zhuye, Wang Peili, Shi Dazhuo#
  

  1. Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;
  • Received:2017-11-24 Online:2018-05-30 Published:2018-05-30
  • Supported by:
    National Natural Science Foundation of China (No. 81030063)

Abstract: Objective To observe the influence of routine statins drugs combined with Guanxin Danshen (Coronary Salvia Root) Gutta Pills and Chuanxinlian (Andrographitis) Tablet on serum inflammatory markers and blood fat in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods ACS patient (n=40) were randomly divided into control group and treatment group (each n=20) after PCI. The control group was treated with basic therapy of Western medicine and statins, and treatment group was additionally given Guanxin Danshen Gutta Pills and Chuanxinlian Tablet for 30 d. The levels of serum high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and blood fat were detected by using ELISA, and integrals of blood stasis pattern were calculated. Results The levels of hs-CRP and TNF-α decreased significantly in 2 groups after treatment (P<0.05 or P<0.01), and difference between 2 groups had statistical significance after treatment (P<0.01). The level of serum total cholesterol (TC) decreased significantly and level of high-density lipoprotein-cholesterol (HDL-C increased in treatment group (P<0.05). The integrals of blood stasis pattern decreased significantly in treatment group after treatment (P<0.01). Conclusion Guanxin Danshen Gutta Pills and Chuanxinlian Tablet, with effects of activating blood and removing toxicity, can further reduce the levels of inflammatory markers, hs-CRP and TNF-α, relieve blood stasis and assist to control blood fat in patients with ACS after PCI.

Key words: activating blood and removing toxicity, coronary heart disease, inflammatory markers, blood fat

CLC Number: 

  • R256.22