主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2018, Vol. 41 ›› Issue (5): 428-433.doi: 10.3969/j.issn.1006-2157.2018.05.013

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Influence of Peiyuan Tongluo Fang on clinical efficacy and micro-inflammation state in patients with diabetic kidney disease*

Liu Hong1, Xiong Weijian1#, Li Ying1, Zhong Lingyun1, Zhou Xiaoli2, Zheng Xin2
  

  1. 1 Department of Nephropathy, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China;
    2 National Medicine Inheritance Studio of Master Zheng Xin, Chongqing Research Institute of Traditional Chinese Medicine, Chongqing 400021, China;
  • Received:2017-01-07 Online:2018-05-30 Published:2018-05-30
  • Supported by:
    National Science Fund for Youth (No. 81603611), Chongqing Natural Science Foundation (No.cstc2017jcyjA0217, No.cstc2017jcyjA0265)

Abstract: Objective To observe the influence of Peiyuan Tongluo Fang (Qi-tonifying Collateral-dredging Decoction, PTF) on clinical efficacy and micro-inflammation state in patients with phase IV diabetic kidney disease (DKD), and investigate the mechanism of PTF in treatment of DKD. Methods Phase IV DKD patients (n=106) were randomly divided into treatment group and control group (each n=53). There were actually 98 patients had complete treatment in 2 groups (each n=49). Besides of basic therapy, the treatment group was treated with PTF, and control group was treated with Niaoduqing Granule for 8 weeks. The changes of TCM patterns and levels of serum creatinine (SCr), estimated glomerular filtration rate (eGFR), 24 h urinary protein excretion (24 h U-pro), urinary microalbumin protein (U-Alb), high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were observed and analyzed statistically in two groups. Results After treatment, all TCM patterns were significantly relieved (P<0.05 or P<0.01) in treatment group compared with before, which were superior to those in control group (P<0.05 or P<0.01). After treatment, levels of SCr, 24 h U-pro and U-Alb decreased significantly (P<0.01) and eGFR level increased (P<0.05) in treatment group compared with before treatment, which were superior to those in control group (P<0.05 or P<0.01). After treatment, levels of hs-CRP, TNF-α and IL-6 decreased significantly (P<0.01) in treatment group compared with before treatment, which were superior to those in control group (P<0.05). The total effective rate was 73.47% (36/49) in treatment group, and 44.90% (22/49) in control group (P<0.05). No adverse reactions were observed in 2 groups. Conclusion PTF combined with basic therapy of Western medicine can effectively reduce urine protein, protect kidney and alleviate micro-inflammation state in patients with phase IV DKD.

Key words: Peiyuan Tongluo Fang (Qi-tonifying Collateral-dredging Decoction), diabetic kidney disease, micro-inflammation state

CLC Number: 

  • R255.4