主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2018, Vol. 41 ›› Issue (6): 516-522.doi: 10.3969/j.issn.1006-2157.2018.06.013

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Effects of acupuncture combined with herbal medicine on the transplant outcome of frozen-thawed embryos and receptivity of endometria in kidney-deficiency patients with multiple implantation failure*

Yang Yuan1, Li Dong2, Xin Xiyan2, Luo Bin1#   

  1. 1 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Peking University Third Hospital, Beijing 100191,China
  • Received:2018-02-26 Online:2018-06-30 Published:2018-06-30
  • Supported by:
    Beijing Science and Technology Plan Funding Project(No.Z141107002514022)

Abstract: Objective To observe the effects of acupuncture combined with herbal treatment on the transplant outcome of frozen-thawed embryos and receptivity of endometria in kidney-deficiency patients with multiple implantation failure. Methods 120 patients who met the diagnostic criteria were randomly divided into a treatment group and a control group. Patients in the control group were treated with routine natural cycle freeze-thaw embryo transfer protocol. Apart from routine protocol, patients in the treatment group took blood activating formula every day and received acupuncture on guanyuan (RN4), qihai (RN6), zigong (EX-CA1), sanyinjiao (SP6, bilateral), taichong (LR3, bilateral), hegu (LI4, bilateral) every other day before the menstruation. No herbal treatment nor acupuncture was administered during the menstruation. After the menstruation, the patients resumed herbal treatment (blood-activating kidney-tonifying formula) every day and acupuncture treatment (RN4, RN6, EX-CA1, bilateral SP6, ST36, and KI3) every other day. Treatment course was three menstrual cycles. Outcome measurements were syndrome scores of kidney deficiency before and after the treatment, estradiol (E2) and progesterone (P) levels, endometrial thickness and blood flow distribution during implantation window. Biochemical and chemical pregnancy rates were also calculated in the two groups after frozen-thawed embryo transfer. Results Symptoms of kidney deficiency had been significantly relievedin the treatment group (P<0.05); this improvement was better than that of the control group (P<0.05). The post-treatment progesterone (P) and estradiol (E2) levels in the corpus luteum phase in the treatment group were significantly higher than those in the confrol group before and after the treatment (P<0.05). The endometrial blood flow distribution is divided into type A, type B and type C. After the treatment, the proportion of type A’s and type B’s distribution of endometrial blood flow were significantly increased, and the proportion of type C was significantly decreased (P<0.05). The post-treatment ratio of type A, B and C in the treatment group were compared between the two groups and there was no statistical difference in type A; but the proportion of type B was significantly higher than that of the control group (P<0.05), and the proportion of type C was significantly lower than that of the control group (P<0.05). The post-treatment endometrial thickness in the treatment group increased remarkedly (P<0.05). After the treatment, the endometrial thicknesses of the treatment group were significantly higher than that of the control groups (P<0.05). After the treatment, the biochemical pregnancy rate and clinical pregnancy rate of the treatment group were higher than those of the control group, and the differences were statistically significant (P<0.05). Conclusion Acupuncture combined with herbal therapy can significantly improve the patient's kidney-deficiency symptems; it can also regulate estrogen and progesterone levels and benefit embryonic implantation, improve endometrial thickness and endometrial blood flow, thereby enhancing endometrial tolerance and improve clinical pregnancy rate.

Key words: endometrial receptivity, natural cycle of frozen-thawed embryo transfer, traditional Chinese medicine, acupuncture, clinical pregnancy rate

CLC Number: 

  • P246.3