主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2018, Vol. 41 ›› Issue (7): 567-571.doi: 10.3969/j.issn.1006-2157.2018.07.007

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Comparison in pharmacodynamics between modified paste and decoction of Jinhui Shenqi Pill in rat model of kidney yang deficiency*

Zheng Longfei, Han Ling, Hao Yu, Gao Zhili, Shi Lingsheng, He Juan#   

  1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicion, Beijing 100029, China
  • Received:2018-01-10 Online:2018-07-30 Published:2018-07-30
  • Supported by:
    National Natural Science Foundation of China (No.81273874)

Abstract: Objective To compare and study the curative effects of modified paste and decoction of Jinhui Shenqi (Kidney-qi Pill in Synopsis of the Golden Chamber) Pill in intervention of rat model of kidney yang deficiency. Methods Male SD rats (n=40) were divided into normal group, model group, group of Jinhui Shenqi Pill paste (paste group) and group of Jinhui Shenqi Pill decoction (decoction group). Expect of normal group, other groups were orally given adenine (200 mg/kg) for 4 weeks for copying rat model of kidney yang deficiency pattern. The paste group and decoction group were respectively given modified paste or decoction of Jinhui Shenqi Pill for 6 weeks. The model group was orally given distilled water and ginseng group was given conventional breeding. On the end of the 6th week, the serum samples were collected from all groups for detecting the hormones of hypothalamus-pituitary-gonadal axis including testosterone (T), estradiol (E2), luteinizing hormone (LH) and human chorionic gonadotropin (HCG), hormones of hypothalamus-pituitary-adrenal axis including adrenocorticotrophic hormone (ACTH), cortisol (COR), 17-hydroxycorticosteroid (17-OH-CS), and hormones of hypothalamus-pituitary-thyroid axis including tri-iodothyronine (T3) and tetra-iodothyronine (T4). Results The content of LH decreased significantly in model group compared with normal group (P<0.05), and increased significantly in paste group and decoction group (P<0.05) but there was no significant difference between paste group and decoction group. The content of E2 decreased significantly in model group compared with normal group (P<0.05), increased significantly in decoction group compared with model group (P<0.05). There was no significant difference in content of E2 between paste group and model group, but it was significantly higher in decoction group than that in paste group (P<0.05). Compared with normal group, content of T had descending trend without significant difference. The content of T increased significantly in paste group and decoction group compared with model group (P<0.05), while there was no significant difference between paste group and decoction group. The content of 17-OH-CS increased significantly in model group compared with normal group (P<0.05), decreased significantly in decoction group compared with model group (P<0.05), and decreased significantly in decoction group compared with paste group (P<0.05). The content of T4 decreased significantly model group compared with normal group (P<0.05), increased significantly in paste group compared with model group (P<0.05) and increased significantly in paste group compared with decoction group (P<0.05). Conclusion The two types of preparation forms of Jinhui Shenqi Pill (paste and decoction) can play a role of warm tonification of kidney yang through increasing content of LH and T, but there is difference between these two types of preparation forms. The decoction of Jinhui Shenqi Pill can warmly tonify kidney yang through increasing content of E2 and decreasing content of 17-OH-CS, but paste of Jinhui Shenqi Pill has no significant effect on these two indexes. The paste of Jinhui Shenqi Pill can warmly tonify kidney yang through increasing content of T4, while decoction of Jinhui Shenqi Pill has no significant effect on this index.

Key words: kidney yang deficiency pattern, Jinhui Shenqi (Kidney-qi Pill in Synopsis of the Golden Chamber) Pill, preparation forms, paste preparation, rats

CLC Number: 

  • R285.5