主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2018, Vol. 41 ›› Issue (7): 599-604.doi: 10.3969/j.issn.1006-2157.2018.07.012

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Influence of Huwang Mingmu Tang on hemodynamics and serum ICAM-1 and ET-1 changes in patients with diabetic retinopathy*

Chen Mei1, Cai Rang1, Qi Huiyan1, Wang Yongqin1, Hu Zuquan2   

  1. 1 First Affiliated Hospital of Guiyang University of Chinese Medicine, Guizhou 550001, China;
    2 Guizhou Medical University, Guizhou 550025, China
  • Received:2018-01-30 Online:2018-07-30 Published:2018-07-30
  • Supported by:
    National Natural Science Foundation of China (No. 31660258), Guizhou Administration of Traditional Chinese Medicine, National Medical Science and Technology Research (No. QZYY2010-15)

Abstract: Objective To investigate the improving effects of Huwang Mingmu Tang (Protecting Retina and Improving Eyesight Decoction) combined with calcium dobesilate on local hemodynamics, serum inflammatory factors and vascular endothelial factors in patients with diabetic retinopathy (DR). Methods DR patients (n=80) were chosen and divided, according to random digital table, into treatment group and control group (each n=40, 80 eyes). The control group was orally given calcium dobesilate capsules 1 capsule/time and 3 times/d. The treatment group was additionally given Huwang Mingmu Tang 1 dose/d, 2 times/d and 10 d/course for 3 courses. The changes of local hemodynamics, serum inflammatory factors and vascular endothelial factors were observed in 2 groups before and after treatment. Results The levels of peak systolic velocity (PSV) and end-diastolic velocity (EDV) of central retinal artery (CRA), posterior ciliary artery (PCA) and ophthalmic artery (OA) increased, and vascular resistance index (RI) decreased in 2 groups after treatment (P<0.01). The levels of PSV and EDV of CRA, PCA and OA were all higher (P<0.01), and RI was lower (P<0.01) in treatment group than those in control group after treatment. The levels of tumor necrosis factor-α (TNF-α), intercellular adhesion molecule-1 (ICAM-1) and interleukin-6 (IL-6) were lower in 2 groups after treatment than before (P<0.01), which was more significant in treatment group (P<0.01). The levels of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) decreased in 2 groups after treatment than before (P<0.01), which was more significant in treatment group (P<0.01). Conclusion Huwang Mingmu Tang combined with calcium dobesilate can treat DR effectively through changing hemodynamics and reducing levels of serum inflammatory factors and VEGF, and has good application prospect in clinic.

Key words: diabetic retinopathy, hemodynamics, serum inflammatory factors, vascular endothelial growth factor

CLC Number: 

  • R276.741