主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2018, Vol. 41 ›› Issue (8): 696-701.doi: 10.3969/j.issn.1006-2157.2018.08.013

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Effects of qi-boosting lung-dredging water-draining formula on chronic heart failure combined with premature ventricular contraction: clinical observation*

Zhang Wei1, Xiao Min1#, Zhang Lijing1, Zhao Yong1, Li Yufeng2, Guo Shi1, Chang Peifen1, Huang Hong3   

  1. 1 Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China;
    2 Institute of Cardiovascular Research, Beijing University of Chinese Medicine, Beijing 100700, China;
    3 Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2017-12-04 Online:2018-08-30 Published:2018-08-30
  • Supported by:
    Key Project of Beijing Natural Science Foundation(No.7161008)

Abstract: Objective To evaluate the efficacy and safety of qi-boosting lung-dredging water-draining formula (Yiqi Xiefei Lishui Fang, YXLF) in the treatment of chronic heart failure with premature ventricular contraction (PVC). Methods Randomized doubled blinded placbo-controlled design was used. 60 patients with chronic heart failure combined with PVC, whose TCM diagnosesn were water diffusion due to deficiency of yang, were randomly divided into experimental group and control group(n=30 in each group). The experimental group received YXLF on the basis of standard treatment for chronic heart failure. Patients in the control group were given standard treatment of chronic heart failure and placebo. The course of treatment was 8 weeks. Outcome measures included the prematurity index, PVC frequency, the Tp-e interval, the Tp-e/QT Electrocardiogram and LVEF, NT-pro BNP, 6-minute walking test, Minnesota Heart Failure Quality of Life Scale (MLHF-Q), TCM Syndrome score and others were compared between the two groups. Results Tp-e / QT value, PVC frequency, and prematurity index were improved compared with those before treatment (P<0.05). But there was no significant difference between the two groups (P>0.05). The Tp-e / QT value of the test group was significantly better than that of the control group (P<0.05). Compared with the control group, the NT-pro BNP, 6MWT, MLHF-Q and TCM Syndrome score of experimental group were all improved (P <0.05), but there was no significant difference in LVEF between the two groups (P> 0.05). In terms of efficacy evaluation with cardiac function classification and PVC frequency, there was no difference of statistical significance between the two groups. But TCM treatment effectiveness of experimental group was superior to that of the control group (P<0.05). Conclusion Qi-boosting lung-dredging water-draining formula can improve the heart function and quality of life in patients with chronic heart failure and ventricular premature beats on the basis of conventional treatment. And it can improve the prematurity index, Tp-e interval, and reduce the risk of malignant arrhythmia.

Key words: Yiqi Xiefei Lishui Fang, chronic heart failure, premature ventricular contraction, patten of yang deficiency with wate flooding

CLC Number: 

  • R256.2