主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2018, Vol. 41 ›› Issue (9): 781-786.doi: 10.3969/j.issn.1006-2157.2018.09.012

Previous Articles     Next Articles

Characteristics of Hamilton Depression Scale and Hamilton Anxiety Scale in patients with depressive disorder-liver depression and spleen deficiency pattern: a study based on association rules and entropy clustering algorithm*

Zhang Yuxiang, Guo Rongjuan, Geng Dong#   

  1. Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
  • Received:2018-03-25 Online:2018-09-30 Published:2018-09-30
  • Supported by:
    Surface Project Sponsored by National Natural Science Foundation (No. 81573843)

Abstract: Objective To study the characteristics of Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) in patients with depressive disorder-liver depression and spleen deficiency pattern. Methods The general data, disease history information, Results of related psychological assessment and examination scales (HAMD and HAMA) and relevant information of TCM from 200 cases were input into TCMISS V2.5 software. All data was statistically analyzed by applying association rules, improved mutual information method and entropy clustering algorithm of complex system. Results HAMD item combinations, extracted based on association rules, included depressed mood, work and interest, mental anxiety, somatic anxiety, systemic symptoms, hypoesthesia, insomnia-early, insomnia-middle, early awakening and gastrointestinal symptoms. There were 7 core combinations evaluated based on entropy clustering algorithm of complex system. HAMA item combinations, extracted based on association rules, included depressed mood, anxious mood, tension, insomnia, symptoms of sensory system, respiratory system and vegetative nervous system, and dysmnesia or attention deficits. There were 3 core combinations evaluated based on entropy clustering algorithm of complex system. Conclusion Liver qi depression is the basic pathogenesis of depressive disorder. As the disease developing, liver depression and spleen deficiency will be the total trend of pathogenesis in depressive patients, and liver depression and spleen deficiency pattern is a most common pattern of depressive disorder. The clinical manifestations of depressive disorder are complex, and symptoms of multiple systems can be displayed. The symptom items from HAMD and HAMA are consistent in 200 patients, and assessment Results of HAMD and HAMA focus on vegetative nervous system, sensory system, respiratory system, gastrointestinal system, muscular system and cardiovascular system in patients with depressive disorder-liver depression and spleen deficiency pattern.

Key words: depression, liver depression and spleen deficiency pattern, Hamilton Depression Scale, Hamilton Anxiety Scale, association rules, entropy clustering

CLC Number: 

  • R277.794