主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2018, Vol. 41 ›› Issue (10): 821-827.doi: 10.3969/j.issn.1006-2157.2018.10.006

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Effects of shenzhiling oral liquid on learning, memory and synaptic structure of APPswe/PSldE9 mice*

Wu Yiqiong, Chen Fang, Sheng Ning, Ren Ying, Yang Jinduo, Wang Pengwen#   

  1. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700,China
  • Received:2018-03-16 Online:2018-10-30 Published:2018-10-30

Abstract: Objective To observe the effects of shenzhiling (SZL) oral liquid on learning, memory and synaptic structure of APPswe/PSldE9 mice. Methods Seventy-five APPswe/PSldE9 mice were randomly divided into model group, donepezil group(0.92 mg/(kg·d)), high-dose SZL (50 g/(kg·d)) group, mid-dose SZL (25 g/(kg·d)) group, and low-dose(12.5 g/(kg·d)) SZL groups (n=15 in each group). 15 C57/BL6J mice were used as the normal control group. For the model and normal group, mice were administered oral gavage of distilled water while the interventional groups received corresponding medicine for three months. Learning and memory was evaluated by using Morris water maze test, and the ultrastructure of the synapses were observed with transmission electron microscope. Results Compared with the normal group, mice in the model group had a longer escape latency and swimming distance (P<0.01); reduced times across the platform and stay in the target platform quadrant (P<0.01). After SZL treatment, escape latency was reduced and the swimming distances was shorter (P<0.05); times across the platform and stay in the target platform quadrant were increased, especially in the mid-dose and low-dose groups (P<0.01). The ultrastructure of the synapses was improved in the SZL groups than that in the model group, especially in the mid-dose and lowdose groups. Conclusion SZL oral liquid could improve learning and memory ability, and improve ultrastructure of the synapses in APPswe/PSldE9 mice. This may be one of the important mechanisms of improving cognitive function.

Key words: Alzheimer’s disease, Morris water maze, synapses, APPswe/PSldE9 mice

CLC Number: 

  • R285.5