主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2018, Vol. 41 ›› Issue (10): 863-872.doi: 10.3969/j.issn.1006-2157.2018.10.013

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Meta-analysis of effectiveness of traditional Chinese medicine in the treatment of oligospermia and asthenospermia*

Li Boyi1, Wang Qi1, Zhu Bin2, Yang Peiying1, Dong Yang1, Yan Ji1, Zheng Yanfei1#   

  1. 1 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine,Beijing 100029,China;
    2 Beijing Tian Tan Hospital,Capital Medical University,Beijing 100050,China
  • Received:2018-01-21 Online:2018-10-30 Published:2018-10-30

Abstract: Objective To evaluate the effectiveness of traditional Chinese medicine in the treatment of oligospermia and asthenospermia. Methods Randomized controlled trials (RCTs) were retrieved from CNKI, Wanfang database, VIP, CBM, PubMed, Cochrane library, EMbase, Web of Knowledge. The date of publication was January 2004 to March 2017. RCTs about traditional Chinese medicine in the treatment of oligospermia and asthenospermia were included. Treatment group received traditional Chinese medicine, while the control group was treated with Western medicine. The quality of included studies was evaluated and performed by using the statistical software STATA12.0. Results A total of 44 RCTs involving 4779 patients were included. Meta-analysis showed that total effective rate [RR=1.15, 95%CI (1.07-1.23), P=1.00], semen volume [MD=0.57, 95%CI (0.44-0.70), P<0.000 01], sperm density [MD=0.82, 95%CI (0.73-0.91), P<0.000 01], percentage of class A sperm [MD=0.72, 95%CI (0.60-0.84), P<0.000 01], percentage of class A + B sperm [MD=0.85, 95%CI (0.74-0.96), P<0.000 01]. Conclusion Traditional Chinese medicine was superior to Western medicine in improving semen volume, sperm density, percentage of class A sperm, percentage of class A + B sperm, and total effective rate.

Key words: oligospermia, asthenospermia, infertility, traditional Chinese medicine, meta-analysis

CLC Number: 

  • R256.56