主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2018, Vol. 41 ›› Issue (10): 873-880.doi: 10.3969/j.issn.1006-2157.2018.10.014

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Meta-analysis of the efficacy and safety of compound Zaofan Pills alone or combined with Western medicine in the treatment of blood diseases*

Zhang Zhichun1, Zhang Xiaobo2, Ding Hao1, Jia Mengran1, Wang Chong1, Chen Xinyi1, Tian Shaodan1#   

  1. 1 Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China;
    2 Chengji Si Khan Town Center Health Center, Zhalantun, Hulunbuir City, Inner Mongolia 162691, China
  • Received:2018-02-24 Online:2018-10-30 Published:2018-10-30

Abstract: Objective To evaluate the efficacy and safety of compound Zaofan pills alone or combined with Western medicine in the treatment of blood diseases. Methods The researchers retrieved the seven authoritative databases commonly used, and searched published randomized controlled clinical trials on compound Zaofan pills alone or combined with Western medicine in the treatment of blood diseases from the establishment of the library to January 2018, and carried out data extraction and quality evaluation, and then the Review Manager 5.3 software was used for Meta analysis. Results Finally, 15 qualified clinical studies were included, among which 11 were aplastic anemia, 3 were myelodysplasia syndromes, and 1 was immune thrombocytopenia. Meta-analysis showed that: ①The overall efficacy evaluation showed that the compound Zaofan pills alone or combined with Western medicine was superior to Western medicine alone (P<0.000 01). ②The efficacy of compound Zaofan pills alone or combined with Western medicine in the treatment of aplastic anemia was better than that of Western medicine alone (P<0.000 01).③The efficacy of compound Zaofan pills alone or combined with Western medicine in the treatment of myelodysplastic syndrome was better than that of Western medicine alone (P=0.002).④Six studies reported treatment-related adverse reactions, mainly mild gastrointestinal reaction and mild liver function damage, but all of them occurred in the combined treatment group, so it could not be determined as the result of compound Zaofan pills. Conclusion Compound Zaofan pills alone or combined with Western medicine seems to be more effective than Western medicine alone in the treatment of aplastic anemia and myelodysplastic syndrome with safety.

Key words: Compound Zaofan Pill, aplastic anemia, myelodysplastic syndromes, meta analysis

CLC Number: 

  • R255.7