主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2018, Vol. 41 ›› Issue (12): 988-994.doi: 10.3969/j.issn.1006-2157.2018.12.004

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Antihypertensive effects of Wuwei Jiangya San on spontaneously hypertensive rats*

Gong Ming1, Wang Wei1, Wang Peipei1, Wang Zhiyin1, Yang Shuangjie1, Liu Junjie1, Li Shaojing2, Li Xueli1, Zhao Huihui1#   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Insititute of Chinese Materia Medica,Chinese Academy of Traditional Chinese Medicine,Beijing 100700, China
  • Received:2018-07-02 Published:2019-01-14

Abstract: Objective To study the effects of Wuwei Jiangya San(five-ingredient antihypertensive formula, WWJY) on spontaneously hypertensive rats and compare the antihypertensive characteristics of WWJY formula, Sancao Jiangya(three-herb antihypertensive, SCJY) decoction and Niuhuang Jiangya(Calculus Bovis antihypertensive, NHJY) pill on spontaneously hypertensive rats (SHR). Methods Forty SHR rats of 14-week-old were randomly divided into four groups: model group, WWJY formula group, SCJY decoction group and NHJY pill group, Wistar-Kyoto (WKY) rats as control group. The blood pressurewas monitored for 10 weeks.Then the changes of the blood pressure, heart rate and rotation tolerance time were observed every week. Samples were taken, to observe the pathological changes of the rats by using HE staining method. Results Compared with control group, the systolic blood pressure (SBP) of model group showed an upward trend (P<0.05), and the rotation tolerance time decreased. Compared with model group, WWJY formula was markedly effective after two weeks (P<0.05), and the SBP was stabled after four-week administration, and the rotation tolerance time were also maintained stable in the later period. SCJY decoction was effective at 0-4 weeks, as the SBP of the group showed inprovement within 4-8 weeks. NHJY pill showed anti-hypertensive effect at week 2. The rotation tolerance duration continuously increased after administration. Compared with model group, the pathological changes in the heart, kidney, and liver tissues were alleviated and improved in all three other interventional groups, especialy in the WWJY group. Conclusion The blood pressure lowering effect of WWJY formula on SHR rats seems to kick in later yet the effect is constant and sustained at the later period, compared to the SCJY decoction and NHJY pill. WWJY formula also has tranquilizing effects,keeping heart rate stable and relieving the pathological damage of liver and kidney.

Key words: Wuwei Jiangya formula, hypertension, rotation tolerance time, pathological changes, rats

CLC Number: 

  • R285.5