主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2019, Vol. 42 ›› Issue (1): 8-11.doi: 10.3969/j.issn.1006-2157.2019.01.002

• Theoretical studies • Previous Articles     Next Articles

Pathogenesis of diabetic nephropathy with essence depletion and collateral impediment

Hu Jiyuan1, Liu Hongfang2#, Zhang Xiangwei3   

  1. 1 Anhui University of Traditional Chinese Medicine, Anhui 230038, China;
    2 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700,China;
    3 Shijingshan Teaching Hospital of Capital University of Medical Sciences, Beijing 100043, China
  • Received:2018-06-06 Online:2019-01-30 Published:2019-03-01
  • Contact: Liu Hongfang, female, PhD., Chief-Physician. Research direction: treatment of endocrine diseases in kidney by traditional Chinese and Western medicine. E-mail: lhfdoctor@126.com
  • Supported by:
    National Natural Science Foundation of China (No. 81774273), Beijing Science and Technology Commission Ten Diseases & Ten medicinals Research and Development Project(No.Z161100001816003)

Abstract: The pathogenesis of essence depletion and collateral impediment can summarize the characteristics of core pathogenesis of diabetic nephropathy (DN) and guide clinical treatment effectively. The pathogenesis of essence depletion emphasizes that kidney lesions is the core of five viscera lesions. Kidney deficiency indicates the consumption of kidney essence and deficiency induces the production of stagnation, dampness, stasis and turbidity. The pathogenesis of collateral impediment indicates that dampness, stasis and turbidity due to deficiency obstruct kidney collateral, even aggregation-accumulation is produced. Therefore collateral impediment is characterized by excess due to deficiency. The therapy of filling essence and freeing collaterals is proposed for DN treatment in the paper. The filling essence refers to nourishing kidney essence, and freeing collaterals refers to eliminating pathogens to free collaterals. It is a kernel therapy for DN. The nourishing kidney essence is a cornerstone in DN treatment, especially in middle or late stages of DN treatment. In early stage eliminating pathogens to resolve impediment (eliminating-freeing therapy) is stressed, and in late stage reinforcing healthy qi and eliminating pathogens (nourishing-freeing therapy) is emphasized. The healthy qi will not be damaged during eliminating pathogens.

Key words: diabetic nephropathy, core pathogenesis, essence depletion, collateral impediment, kidney essence

CLC Number: 

  • R256.5