主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2019, Vol. 42 ›› Issue (1): 58-62.doi: 10.3969/j.issn.1006-2157.2019.01.010

• Chinese Medicinal Pharmacology • Previous Articles     Next Articles

Anti-fatigue effects of aqueous extracts from Xianye Jinquehua and Zanghonghua

Ma Qing, Fan Chunlan, Tang Minke#   

  1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
  • Received:2018-06-01 Online:2019-01-30 Published:2019-03-01
  • Contact: Tang Minke, male, PhD., Professor, Doctoral Supervisor. Research direction: neuropharmacology. E-mail: tangmk@ bucm.edu.cn
  • Supported by:
    Drug Discovery Initiative of Ministry of Science and Technology (No. 2011ZX09201-201-22)

Abstract: Objective To study the anti-fatigue effects of aqueous extracts from Xianye Jinquehua (Rooibos, Aspalathus Linears) and Zanghonghua (Saffron, Crocus sativus L.) through classic behavior test (loaded swimming) and detections of blood lactic acid, liver glycogen and muscle glycogen. Methods At first 32 mice were randomly divided into blank control group, Xianye Jinquehua group and Zanghonghua group, and were orally given corresponding medicinals once a day. The test of loaded swimming was conducted in all groups after 14 d. Then 46 mice were randomly divided into blank control group and low-dose Xianye Jinquehua+Zanghonghua group, and were orally given corresponding medicinals once a day. The test of loaded swimming and detection of blood lactic acid were conducted in all groups after 14 d. According to above test results, 100 mice were randomly divided into blank control group, low-dose Xianye Jinquehua+Zanghonghua group, mid-dose Xianye Jinquehua+Zanghonghua group and high-dose Xianye Jinquehua+Zanghonghua group. After oral medication for 14 d, the content of liver glycogen and muscle glycogen was detected. Results The time of loaded swimming was not improved in Xianye Jinquehua group and Zanghonghua group, and it was prolonged (P<0.05) and content of blood lactic acid was decreased (P<0.05) in low-dose Xianye Jinquehua+Zanghonghua group. The content of liver glycogen and muscle glycogen was increased in low-dose Xianye Jinquehua+Zanghonghua group, mid-dose Xianye Jinquehua+Zanghonghua group and high-dose Xianye Jinquehua+Zanghonghua group compared with blank control group (P<0.05 or P<0.01). Conclusion The single administration of single Xianye Jinquehua or single Zanghonghua has no anti-fatigue effect, while combination of them has this effect.

Key words: Xianye Jinquehua (Rooibos, Aspalathus Linears), Zanghonghua (Saffron, Crocus sativus L.), loaded swimming, blood lactic acid, liver glycogen, muscle glycogen, anti-fatigue effect, mice

CLC Number: 

  • R285.5