主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2019, Vol. 42 ›› Issue (2): 167-170.doi: 10.3969/j.issn.1006-2157.2019.02.013

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Influence of Erbu Zhuyu Tang on endometrial ultrasound indexes in patients with repeated failures of in vitro fertilization-embryo transfer

Shen Mengmeng1, Liu Yanfeng2#, Liang Jialing2, Pan Xue2, Xu Xiuli2   

  1. 1 Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
  • Online:2019-02-28 Published:2019-02-28
  • Contact: Liu Yanfeng, MD., Doctoral Supervisor. Department of Gynecology, Dongzhimen Hospital, Beijing University of Chinese Medicne. E-mail: liuyaf888@sina.com

Abstract: Objective To observe the influence of Erbu Zhuyu Tang (Double Tonifying Medicinals for Helping Pregnancy Decoction, EZT) on endometrial ultrasound indexes in patients with repeated failures of in vitro fertilization-embryo transfer (IVF-ET), and discuss the improvement effect of EZT on endometrial receptivity. Methods The patients (n=32) with repeated IVF-ET failures (2 times or more), except of factor of embryo quality, were chosen by using self-control test, and they were diagnosed as pattern of kidney deficiency and blood stasis with pattern differentiation of Chinese medicine. The changes of endometrial ultrasound indexes and pregnant outcomes after once again IVF were observed in the patients before and after treatment with EZT. Results Among 32 patients, one lost to follow-up and one was excluded because of non-adherence treatment, and finally 30 patients were included into statistical analysis. The endometrial thickness increased (P<0.001), and numbers of patients with type A endometrium and blood flow under the endometrium increased (P<0.001) after treatment. Salle scorse increased significantly after treatment (P<0.001). The pulse index (PI) and resistance index (RI) of bilateral uterine artery, and S/D ratio of left uterine artery decreased significantly (P<0.05, P<0.001) after treatment. The rate of again IVF-ET was 40% and clinical pregnancy rate was 33.33%. Conclusion EZT can improve blood flow of uterine artery, and endometrial receptivity in aspects of endometrial thickness, types and blood supply, which is conducive to improvement of embryo implantation and success rate of again IVF-ET.

Key words: Erbu Zhuyu Tang (Double Tonifying Medicinals for Helping Pregnancy Decoction), endometrial receptivity, in vitro fertilization, embryo transfer, ultrasound indexes

CLC Number: 

  • 32133