主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2019, Vol. 42 ›› Issue (5): 430-435.doi: 10.3969/j.issn.1006-2157.2019.05.012

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Treatment of acute exacerbation of chronic obstructive pulmonary disease-phlegm-heat congesting lung pattern with Qingfei Huatan Tang through immune regulation*

Guo Fang1, Guo Yuanhui2, Feng Cuiling1#, Li Fengsen3, Dong Bin4, Li Baoping4   

  1. 1 Peking University People’s Hospital, Beijing 100044, China;
    2 Beijing Kangyide Pulmonary Hospital Integrated Traditional Chinese and Western Medicine, Beijing 101499, China;
    3 Hospital of Traditional Chinese Medicine, Xinjiang Uygur Autonomous Region, Xinjiang 830000, China;
    4 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700 China
  • Received:2018-12-14 Online:2019-05-30 Published:2019-06-05
  • Contact: Prof. Feng Cuiling, Ph.D., Chief Physician, Doctoral supervisor. Peking University People’s Hospital, No. 11, Xizhimen Nandajie Road, Xicheng District, Beijing 100044. E-mail: fengcuiling@sina.com

Abstract: Objective To investigate the immune regulation mechanism of Qingfei Huatan Tang(Lung-clearing Phlegm-resolving Decoction, QFHT Decoction) in treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD)-phlegm-heat congesting lung pattern. Methods The patients with AECOPD-phlegm-heat congesting lung pattern (n=64) were randomly divided into treatment group and control group. The control group was given therapies of anti-infection, relieving asthma and mechanical ventilation in necessity. The treatment group was additionally given QFHT Decoction based on the same therapies in control group for 7 d. The changes of symptoms were observed, including cough, expectoration, panting, shortness of breath, spontaneous sweating, wheezing, lassitude of spirit and laziness to speak, loss of appetite and abdominal distension after meal, before and after treatment. The cells of peripheral blood C-reactive protein (CRP) and CD4+CD25+FoxP3+Treg, percentage of Th17, expression of TLR4 mRNA, levels of serum interleukin-8 (IL-8), noradrenalin (NE) and tumor necrosis factor-α (TNF-α), and absorbance of nuclear factor-κB (NF-κB) were compared in 2 groups before and after treatment. Results The clinical symptoms were all significantly relieved in 2 groups after treatment. The symptoms including expectoration, panting, shortness of breath, wheezing and abdominal distension after meal were significantly relieved in treatment group compared with control group (P<0.05), and control rate was significantly higher in treatment group than that in control group (P<0.05). The levels of serum NE and TNF-α, expressions of TLR4 mRNA, and percentage of peripheral blood Th17 decreased significantly in treatment group compared with control group (P<0.05). Conclusion QFHT Decoction combined with Western drugs can relieve clinical symptoms more significantly in AECOPD patients. QFHT Decoction may intervene the inflammatory reactions of AECOPD through regulating TLR4-MyD88/TRIF-NF-κB signaling pathway and acquired immunity mediated by Th17 on the base of animal studies.

Key words: acute exacerbation of chronic obstructive pulmonary disease, immune regulation, Qingfei Huatan Tang(Lung-clearing Phlegm-resolving Decoction), phlegm-heat congesting lung pattern

CLC Number: 

  • R259.63