主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2019, Vol. 42 ›› Issue (6): 483-489.doi: 10.3969/j.issn.1006-2157.2019.06.009

• Chinese Medicinal Pharmacology • Previous Articles     Next Articles

Mechanism of Mahuang Fuzi Xixin Decoction in treating allergic rhinitis based on biomolecular network regulation*

Xu Tian, Lian Yajun, Song Danping, Zhang Shuang, Fan Shuning, Ma Chongyang, Cheng Fafeng, Wang Xueqian, Wang Qingguo#   

  1. School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
  • Online:2019-06-05 Published:2019-06-05
  • Contact: Prof. Wang Qingguo, Ph.D., School of Chinese Medicine, Beijing University of Chinese Medicine, No.11, North Third Ring Road, Chaoyang District, Beijing, 100029. E-mail: wangqg8558@sina.com

Abstract: Objective To study the mechanism of Mahuang Fuzi Xixin Decoction (MFXD) in treating allergic rhinitis.Methods The effective components of Mahuang Fuzi Xixin Decoction were obtained by using TCMSP database(oval bioavailability≥30% and medical similarity≥0.18). UniProt database was used to unify the terms of effective targets of MFXD, and comparative toxicology genetics database (CTD) was used to annotate target-related diseases, and as a result, MFXD anti-allergic rhinitis related targets were obtained. The above targets were input into the String database for protein-protein interaction network prediction. Finally, gene ontology (GO) and Kyoto gene and genome encyclopedia (KEGG) enrichment analysis were carried out using the DAVID database to reveal the potential signal pathway of MFXD in the treatment of allergic rhinitis.Results 35 active ingredients and 112 anti-allergic rhinitis targets of MFXD were selected. Its anti-allergic rhinitis may be related to human tumor protein P53 (TP53), transcription factor AP-1 (JUN), interleukin 6 (IL-6), vascular endothelial growth factor (VEGFA) and tumor necrosis factor (TNF).In addition, anti-allergic rhinitis targets of MFXD significantly enriched in calcium signaling pathways, nucleotide combined with structure of oligomerization domain (NOD) receptor signaling pathways, T cell receptors signaling pathways, mitogen activated protein kinase (MAPK) signaling pathway, toll-like receptors signaling pathways, such as cytokines, cell factor receptor interaction signaling pathways.Conclusion MFXD can regulate biomolecular networks with multiple targets and multiple pathways, and its potential anti-allergic rhinitis, multiple pathways biological mechanism may be related to calcium signaling, nod-like receptor, t-cell receptor, MAPK, toll-like receptor and other signaling pathways.

Key words: Mahuang Fuzi Xixin Decoction, allergic rhinitis, biomolecular network, biological mechanism

CLC Number: 

  • R285.5