主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2019, Vol. 42 ›› Issue (7): 560-565.doi: 10.3969/j.issn.1006-2157.2019.07.007

• Chinese Medicinal Pharmacology • Previous Articles     Next Articles

Effects of Açaí and its alcohol extract on the immunity, endocrine hormone and neurotransmitter of mice with deficiency-heat and deficiency-cold pattern*

Li Wei1, Zhou Xue1, Yue Na1, Hou Yan1, Qu Yan2, Zhang Jianjun1, He Cheng3, Wang Linyuan2#   

  1. 1 School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
    2 School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China;
    3 Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2019-01-25 Online:2019-07-30 Published:2019-09-03
  • Contact: A/Professor. Wang Linyuan, Master, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029. E-mail: wanglinyuan110@vip.163.com.

Abstract: Objective To investigate the immunity, endocrine hormone and neurotransmitter of Açaí alcohol extract on deficiency-heat and deficiency-cold models and to clarify the material basis of the cool properties of Açaí. Methods KM male mice were randomly divided into normal group, deficiency-heat model group, deficiency-heat + Açaí group, deficiency-heat + Açaí alcohol extract group, deficiency-cold model group, deficiency-cold + cinnamon group, deficiency-cold +Açaí group, deficiency-cold +Açaí alcohol extract group. The mice were administered orally at the dose of 160 mg/kg thyroxine and 25 mg/kg hydrocortisone in the afternoon per day for 14 days to induce deficiency-heat and deficiency-cold models respectively; each administration group was given the corresponding medication. At the end of the experiment, changes of related immune factors, endocrine hormones and neurotransmitter were measured. Results Consistent with Açaí, Açaí alcohol extract can improve the symptoms of asthenia fever, such as increased autonomous activity, easily irritated and active reaction in mice. It can reduce the level of immune factors such as IgG, C3, C4 (P<0.01, P<0.001, P<0.01), increase CORT (P<0.01), decrease E2 (P<0.01), elevate 5-HT (P<0.01), and reduce the NE content (P<0.001). Açaí alcohol extract had an effect on deficiency-heat model, in contrast to cinnamon, while there was no significant effect on the deficiency-cold model. Conclusion The alcohol extract of Açaí is the material basis of the cool properties of Açaí.

Key words: Açaí, Açaí alcohol extract, immune factor, endocrine hormone, neurotransmitter, material basis, mice

CLC Number: 

  • R285.5