主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2019, Vol. 42 ›› Issue (8): 667-672.doi: 10.3969/j.issn.1006-2157.2019.08.010

• Clinical Studies • Previous Articles     Next Articles

A systematic review on heat-clearing and toxicity-removing therapy for Alzheimer’s disease*

Shi Jing1, NI Jingnian1, Tian Jinzhou1#, Wei Mingqing1, Zhang Xuekai1, Li Ting1, Tian Haolin1, Huang Qiang1, Liang Junjie1, Wang Yongyan2   

  1. 1 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
    2 Institute of Chinese Basic Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2019-02-11 Online:2019-08-30 Published:2019-09-04
  • Contact: Prof. Tian Jinzhou, Ph. D., Chief Physician, Doctoral supervisor, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5, Haiyuncang Street, Dongcheng District, Beijing 100700. E-mail:jztian@hotmail.com

Abstract: Objective To review systematically the curative effect and safety of heat-clearing and toxicity-removing therapy [Huanglian Jiedu Tang (Coptis Root Removing Toxicity Decoction)] on Alzheimer’s disease (AD). Methods The databases of CNKI, WanFang Data and PubMed were retrieved for screening clinical randomized controlled trials (RCTs) about AD treatment with heat-clearing and toxicity-removing therapy from database establishment time to May 22, 2019. The quality of the RCTs was reviewed by applying Jadad scale, and curative effect of Chinese medicinals with effects of clearing heat and removing toxicity was given a Meta-analysis by using RevMan 5.3 software from Cochrane Library. The mean differences of relative risk (RR), mini-mental status examination (MMSE) and activities of daily living (ADL) were calculated. Results There were totally 6 RCTs enclosed and 344 AD cases in test group and 328 in control group. The results of Meta-analysis showed that the clinical improvement rate was higher in test group than that in control group (RR=1.27, 95%CI: 1.08-1.50,I2=0%, P=0.004), and MMSE had significant difference between 2 groups (MD=2.69, 95%CI: 2.13-3.26, I2=84%, P<0.000 01). In addition, heat-clearing and toxicity-removing therapy improved ADL in AD patients (MD=-3.40, 95%CI: -4.92~-1.87, I2=59%, P<0.000 01). Conclusion The heat-clearing and toxicity-removing therapy is safe and effective in AD treatment, and can improve patients’ cognitive function and ADL. It tends to be used in AD patients complicated by behavioral and psychological symptoms in moderate or advanced stages.

Key words: clearing heat and removing toxicity, Alzheimer’s disease, systematic review

CLC Number: 

  • R277.7