主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2019, Vol. 42 ›› Issue (8): 680-684.doi: 10.3969/j.issn.1006-2157.2019.08.012

• Clinical Studies • Previous Articles     Next Articles

Depression and synaptic microenvironment*

Ren Feifei1, Guo Rongjuan2#, Gao Wei1, Yu Yao1, Liu Shuhan1, Li Yang1   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
  • Received:2019-04-22 Online:2019-08-30 Published:2019-09-04
  • Contact: Prof. Guo Rongjuan, Ph. D., Chief Physician, Doctoral supervisor. Dongfang Hospital, Beijing University of Chinese Medicine, No. 6, Area 1, Fangxing Yuan, Fangzhuang, Fengtai District, Beijing 100078. E-mail:381160563@qq.com

Abstract: Depression is a major disease that threatens human health, but its pathogenesis is still unclear at present. The structure and functional changes of neuronal synapses play an important role in the pathogenesis of depression. Synaptic microenvironment is the internal and external environment in which neuronal synapses locate. It is affected by various pathological factors such as inflammation, oxidative stress and disorders of mitochondrial energy metabolism. Synaptic microenvironment is related to the development of depression and can provide new ideas for research on depression mechanism. However, there are few studies on synaptic microenvironment currently. Future research needs to pay more attention to the relationship between depression and synaptic microenvironment, and then propose a new strategy for depression treatment targeting the synaptic microenvironment.

Key words: depression, synaptic microenvironment, synapsis, influencing factors

CLC Number: 

  • R749.4