主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2019, Vol. 42 ›› Issue (8): 697-704.doi: 10.3969/j.issn.1006-2157.2019.08.015

• Clinical Studies • Previous Articles    

Clinical medication regularity in treatment of bronchial asthma with Chinese medicinals in recent 30 years: a dada mining study*

Yang Qinjun1, Yang Cheng2, Tong Jiabing2, Li Zegeng1,2#, Wang Xinheng1, Gao Yating1   

  1. 1 Anhui University of Chinese Medicine, Anhui 230012, China;
    2 First Affiliated Hospital of Anhui University of Chinese medicine, Anhui 230031, China
  • Received:2019-02-09 Online:2019-08-30 Published:2019-09-04
  • Contact: Prof. Li Zegeng, Doctoral supervisor. School of Traditional Chinese Medicine, Anhui University of Chinese Medicine, No. 1, Qianjiang Road, Xinzhan District, Hefei 230012. E-mail: Li6609@126.com

Abstract: Objective To discuss the characteristics of clinical medication and regularity of formula construction in treatment of bronchial asthma with Chinese medicinals based on data mining. Methods The databases including CNKI, WanFang Data, VIP Database and CBM were retrieved for searching the documents about treatment of bronchial asthma with Chinese medicinals and establishing a database of TCM formulas and medicinals. The study on the documents was conducted through frequency statistics, association rules analysis, system cluster analysis and principal component factor analysis. Results There were totally 1132 formulas included involving 342 medicinals and 60 high-frequent medicinals such as Mahuang (Ephedra, Herba Ephedrae), Gancao (Liquorice Root, Radix Glycyrrhizae), Kuxingren (Bitter Apricot Kernel, Semen Armeniacae Amarum), Dilong (Earthworm, Lurmbricus) and Banxia (Pinellia Tuber, Rhizoma Pinelliae), etc. The medicinals commonly used were those with effects of resolving phlegm, suppressing cough and calming panting, tonifying deficiency and releasing the exterior. There were 32 binomial correlations and 18 trinomial correlations obtained from association rules analysis. There were 19 combinations obtained from clustering analysis, and 21 common factors obtained from factor analysis. Conclusion The treatment of bronchial asthma with Chinese medicinals pays attention to therapies of suppressing cough and calming panting, dispersing wind and diffusing lung, and extinguishing wind to arrest convulsions. When deficiency complications enter in collaterals in chronic diseases, the therapies of tonifying lung, spleen and kidney, and dispelling stasis and freeing collaterals should be stressed.

Key words: bronchial asthma, Chinese medicine, data mining, medication regularity

CLC Number: 

  • R256.1