主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2019, Vol. 42 ›› Issue (9): 773-777.doi: 10.3969/j.issn.1006-2157.2019.09.012

• Clinical Studies • Previous Articles     Next Articles

Relationship between pathogenesis of spleen deficiency in depression and mitochondrial energy metabolism disorder*

Liu Shuhan1, Guo Rongjuan2#, Yu Yao1, Ren Feifei1, Li Yang1   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China
  • Received:2019-05-07 Online:2019-09-30 Published:2019-09-27
  • Contact: Prof. Guo Rongjuan, Ph. D., Chief Physician, Doctoral Supervisor. Dongfang Hospital of Beijing University of Chinese Medicine. No. 6, Fangzhuang Fangxingyuan Yiqu, Fengtai District, Beijing 100078. E-mail: dfguorongjuan@163.com
  • Supported by:
    National Natural Science Foundation of China (No. 81874422)

Abstract: Depression is a syndrome characterized by low spirit, mental retardation and decreased volitional activity. As a common TCM clinical pattern related to depression, spleen deficiency is an important pathogenesis of depression. Mitochondrial energy metabolism disorder often exists in the pathophysiological process of depression. The pathogenesis of spleen deficiency is closely related to mitochondrial energy metabolism disorder. Spleen-fortifying qi-boosting medicinals have obvious effects on depression and mitochondrial damage.

Key words: depression, spleen deficiency, mitochondria, energy metabolism, spleen-fortifying qi-boosting

CLC Number: 

  • R277.749