主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2019, Vol. 42 ›› Issue (12): 1038-1042.doi: 10.3969/j.issn.1006-2157.2019.12.011

• Clinical Studies • Previous Articles     Next Articles

Research on progression in TCM pattern of Alzheimer’s disease based on cognitive levels*

Shi Jing, Teng Yu’ou, Wei Mingqing, Li Ting, Ni Jingnian, Zhang Xuekai, Li Chenmeng, Zhou Mengling, Huang Qiang, Wang Xu, Tian Jinzhou#   

  1. Third Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
  • Received:2019-06-12 Online:2019-12-30 Published:2020-01-06
  • Contact: Prof. Tian Jinzhou, Ph.D., M.D., Chief Physician, Doctoral Supervisor. Dongzhimen Hospital, Beijing University of Chinese Medicine. No.5, Haiyuncang Street, Dongcheng District, Beijing 100700. E-mail:jztian@hotmail.com

Abstract: Objective To explore the way of progression in terms of pattern in traditional Chinese medicine (TCM) of patients with Alzheimer’s disease (AD) based on different cognitive levels. Methods A total of 5410 subjects from the Third Department of Neurology of Dongzhimen Hospital, Beijing University of Chinese Medicine were assigned into normal control group (NC) (n=1664), mild cognitive impairment (MCI) group (n=928), mild AD group (MMSE score 21~26, n=223), moderate AD group (MMSE score 11~20, n=447) and severe AD group (MMSE score 0~10, n=299) based on their neuropsychological assessments, case histories, and neuro-imaging and laboratory tests. Patterns in TCM of the patients were then classified, and the way of progression in terms of TCM pattern of the five groups were explored. Results The prevalence of liver-deficiency pattern and spleen-deficiency pattern in the NC group was significantly higher than that in MCI group, which, in turn, was higher than that in the AD groups (all P<0.01). The percentage of kidney-deficiency pattern in the NC group was significantly lower than that in the MCI and mild AD groups (all P<0.01). The occurrence rate of phlegm-turbidity pattern, fire-heat pattern and blood-stasis pattern in the moderate AD group was significantly higher than that in the mild AD group (all P<0.01) and severe AD group (P<0.01 or P<0.05). Compared with the other groups, the rate of extreme-deficiency pattern and excess-toxin pattern in the severe AD group was the highest (all P<0.01). Conclusion Kidney-deficiency pattern existed in all stages of AD. Kidney-deficiency pattern and spleen-deficiency pattern were the main characteristic patterns of patients with mild AD. Phlegm-turbidity pattern, fire-heat pattern and blood-stasis pattern were the common patterns of patients with moderate AD. In severe AD patients, excess-toxin pattern and extreme-deficiency pattern were the prominent patterns. The Results proved that the progression of AD in terms of TCM pattern “begins with kidney deficiency, progresses to fire due to phlegm and stasis, and worsens with extreme deficiency and toxin excess”.

Key words: Alzheimer’s disease, pattern in Chinese medicine, progression, cognition

CLC Number: 

  • R277.743