主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2020, Vol. 43 ›› Issue (1): 74-78.doi: 10.3969/j.issn.1006-2157.2020.01.013

• Clinical Studies • Previous Articles     Next Articles

Evolution of TCM pattern elements after intravenous thrombolysis in patients with acute cerebral infarction*

Wu Jing1, Zhang Zhichen2, Li Zhonghao1, Liu Chongchong1, Dong Xiaoke1, Liu Jinmin2#   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
  • Received:2019-07-12 Published:2020-02-21
  • Contact: Prof. Liu Jinmin, Ph.D., Chief Physician, Doctoral Supervisor. Dongfang Hospital, Beijing University of Chinese Medicine, No.6, Area 1, Fangxing Yuan, Fangzhuang, Fengtai District, Beijing 100078. E-mail: jmvip@vip.163.com
  • Supported by:
    National Natural Science Foundation of China (No.81774277), Research Funded Project of the State Administration of Traditional Chinese Medicine (No.JDZX2015288), Capital Characteristic Clinic Project (No.Z161100000516105)

Abstract: Objective To study the distribution of pattern elements and their evolution over time in patients with acute cerebral infarction undergoing intravenous thrombolysis within 14 days of onset. Methods 56 patients with rt-PA intravenous thrombolysis within 6 hours after the onset of cerebral infarction were included. The information of TCM pattern elements was collected on the 1st, 3rd, 5th, 7th and 14th day after the onset of disease. Various information and data were synthesized for statistical analysis. Results In the evolution of the pattern elements of patients, the wind pattern was the dominart one on the 1st day; the proportion of blood-stasis pattern and phlegm-dampness pattern was also high. As the disease progressed, the proportion of internal wind pattern rapidly decreased on the 3rd day and disappeared on the 14th day; the proportion of phlegm-dampness pattern and blood-stasis pattern showed a downward trend but still maintained high. As time passed, the proportion of qi-deficiency pattern gradually increased and became the highest one on the 7th day. The proportion of internal-fire pattern rised on the 5h day and tended to the initial level; the proportion of yin-deficiency pattern was always low with a downward trend over time. Conclusion In the early stage of cerebral infarction, excess pattern dominated the pattern elements of patients. Among them, wind pattern seems to be the main factor. The combination of every two of wind, phlegm and stasis patterns topped the list, followed by that of all three basic patterns. Compared with previous studies on the evolution of pattern elements of cerebral infarction, the patients’ clinical pattern form in this study gradually reduces after thrombolytic therapy, with decreasing excess pattern and more prominent qi-deficiency pattern.

Key words: cerebral infarction, pattern elements, intravenous thrombolysis

CLC Number: 

  • R255.2