主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2020, Vol. 43 ›› Issue (2): 98-102.doi: 10.3969/j.issn.1006-2157.2020.02.002

• Theoretical Studies • Previous Articles     Next Articles

Pathogenesis of “water cold resulting in inhibition of the wood” in Parkinson’s disease with depression*

Chen Hongjing1,2, Li Xiaoli1#, Liu Haipeng1,2, Lin Liangyin1,2, Diao Huaqiong1,2, Ding Haiyue1,2, Wei Dan1,2   

  1. 1 The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2019-09-02 Published:2020-03-24
  • Contact: Li Xiaoli, Ph.D.,Chief Physician, Doctoral Supervisor.The Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029, China.E-mail: tigerlxl2002@163.com
  • Supported by:
    Beijing Municipal Science & Technology Commission(No.Z141107002514136)

Abstract: “Water cold resulting in inhibition of the wood” refers to that kidney yang deficiency and cold coagulation in the kidney may lead to failune of the kidney to warm the liver and liver qi stagnation. This pathogenesis originated from the Huangdi Neijing (Huangdi’s Internal Classic), and has been developed and applied to diseases of various systems by later physicians. Based on literature research, it is observed that this pathogenesis could possibly be applied in interpreting the mechanism of Parkinson’s disease with depression (PDD) from TCM perspective. For PDD, yang deficiency and cold coagulation of the kidney is the root of the attack, and liver qi stagnation appears in the initial stage. According to various clinical studies, the therapeutic method of warming the kidney yang to relieve liver qi stagnation is effective in treating PDD. Based on such findings, we have developed a formula (composed of Zhifuzi (prepared aconite root, Radix Aconiti Lateralis Praeparata), Bajitian (morinda root,Radix Morindae Officinalis), Chaihu (bupleurum, Radix Bupleuri)) with corresponding effects, which proves to be 70%effective. Pharmacological studies also show that certain traditional Chinese medicinals with the effect of warming the kidney or relieving the liver qi stagnation can show some effect in the treatment of PDD. These research results support the exploration of the pathogenesis of PDD from the perspective of “water cold resulting in inhibition of the wood”. This article has explored such a pathogenesis in PDD based on literature reviews of classical TCM literature, relevant theories and modern studies, in order to provide new ideas and references for the pathogenesis research and clinical treatment of PDD.

Key words: Parkinson’s disease, Parkinson’s disease with depression, water cold resulting in inhibition of the wood, pathogenesis

CLC Number: 

  • R277.7