主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2020, Vol. 43 ›› Issue (5): 357-362.doi: 10.3969/j.issn.1006-2157.2020.05.001

• COVID 2019 Forum •     Next Articles

Exploring the mechanism and treatment of lung-kidney impairment in novel coronavirus pneumonia by using the “lung-sanjiao moyuan-kidney” model theory*

Dong Fei1, Liu Hongliang2, Gu Xiaohong1#   

  1. 1. School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029,China;
    2. Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053,China
  • Received:2020-02-13 Published:2020-06-08
  • Contact: Gu Xiaohong, Chief Physician, Doctoral Supervisor. Beijing University of Chinese Medicine. No.11, Beisanhuan Donglu Road, Chaoyang District, Beijing 100029,China. E-mail:guxh1003@126.com
  • Supported by:
    National Key Research and Development Project, Ministry of Science and Technology (No.2018YFC1704100, No.2018YFC1704101)

Abstract: The novel coronavirus pneumonia is mainly characterized by involvement of pulmonary interstitial lesions. Among patients with increased expression of virus in the kidney, lung-kidney impairment tends to manifest from the early stage after onset. For patients with older age and underlying diseases, their lung and kidney seem to be both involved at later stages, which may then develop into multiple organ failure syndrome (MOFS). The “lung-sanjiao (triple energizer) moyuan (membrane source)-kidney” theory in traditional Chinese medicine (TCM) considers that lung mesenchyme and kidney mesangial membranes are the material basis for triple energizer membrane source to play its role, which is highly consistent with the pathogenesis theory of “[epidemic] pathogens lurking in the membrane source” proposed by Wu Youke in book titled On Epidemic Diseases (Wen Yi Lun). This paper articulates the model theory of “lung-triple energizer moyuan-kidney”, to reason how and why the treatment methods of “treating the upper, [middle] and lower jiao respectively (fen xiao shang xia)” by Ye Tianshi in the book titled On Warm & Heat Diseases (Wen Re Lun) are widely used and also effective in clinical practice. This model theory may serve as reference for the further application of the TCM classic theories in the treatment of emerging and emergent infectious diseases.

Key words: novel coronavirus pneumonia, sanjiao moyuan, lung-kidney impairment, divide and resolve the upper and lower (fen xiao shang xia)

CLC Number: 

  • R254.3