主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2020, Vol. 43 ›› Issue (5): 393-401.doi: 10.3969/j.issn.1006-2157.2020.05.008

• Chinese Medicinal Pharmacology • Previous Articles     Next Articles

Effect of Haizao Yuhu Decoction and its recipe removing antagonistic medicinal combination on the thyroid hormone level and tissue morphology in rats with goiter*

Lyu Yanmin, Xiu Linlin#, Liu Haiyan, Zhang Jingxuan, Li Na, Zhang Chen, Xu Wan, Chen Feng, Wang Xin, Ge Chaoran, Chen Shaohong, Zhong Gansheng   

  1. Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2019-11-04 Published:2020-06-08
  • Contact: Xiu Linlin, Ph.D., Lecturer. Beijing University of Chinese Medicine, No.11 North Third Ring Road, Chaoyang District, Beijing 100029, China. E-mail: xiulinlin1231@126.com
  • Supported by:
    National Natural Science Foundation of China (No. 81573630); Research Project for Fundamental Research in Central Universities (No. 2018-JYBZZ-XJSJ001)Ethical review: Committee of Ethic Review on Medical and Experimental Animals in Beijing University of Chinese Medicine (No. BUCM-4-2018110202-4036)

Abstract: Objective To comparative the thyroid hormone level and histopathological changes of the thyroid tissue in PTU-induced goiter rats treated with Haizao Yuhu Decoction and its recipe minus antagonistic medicinal combination, and to explore whether eliminating antagonistic medicinal combination in Haizao Yuhu Decoction can affect the therapeutic effect. Methods The rats were randomly divided into the blank group, model group, positive drug group (euthyrox),Haizao Yuhu Decoction group,Haizao Yuhu Decoction minus Glycyrrhizae group, Haizao Yuhu Decoction minus Sargassum group, and Haizao Yuhu Decoction minus Sargassum and Glycyrrhizae group. The rat model of goiter was induced with propylthiouracil. Each group was fed with the corresponding drug or decoction. The concentration of serum related indicators was detected, including the thyroid coefficient, thyroid hormone level and its synthesis, transport and regulation. Under light microscope, pathological changes of thyroid tissue in rats were observed, and nucleic number and follicular area in sections were counted. Results Like the positive drug, Haizao Yuhu Decoction was consistent with the positive drug of euthyrox in maintaining thyroid functions and recovering the pathological damage of thyroid tissue in PTU-induced goiter rats. Comparing the thyroid hormone related indicators,the degree of recovery was listed: Haizao Yuhu Decoction group>Haizao Yuhu Decoction minus Glycyrrhizae group>Haizao Yuhu Decoction minus Sargassum group>Haizao Yuhu Decoction minus Sargassum and Glycyrrhizae group. Comparing the histopathological changes of the thyroid tissues, the alleviating degree was listed: Haizao Yuhu Decoction group>Haizao Yuhu Decoction minus Sargassum and Glycyrrhizae group>Haizao Yuhu Decoction minus Sargassum group>Haizao Yuhu Decoction minus Glycyrrhizae group. Conclusion The therapeutic effect of Haizao Yuhu Decoction in regulating thyroid hormone level and improving histopathological changes in goiter rats seems to be better than its recipe minus antagonistic medicinal combination, and the Haizao Yuhu Decoction minus Sargassum and Glycyrrhizae tends to have the least effect.

Key words: Haizao Yuhu Decoction, antagonistic medicinal combination, goiters, thyroid hormone, thyroid morphology

CLC Number: 

  • R285.5