主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2020, Vol. 43 ›› Issue (6): 449-456.doi: 10.3969/j.issn.1006-2157.2020.06.002

• Novel Coronavirus Pneumonia • Previous Articles     Next Articles

Exploration of characteristics of TCM formulae for novel coronavirus pneumonia based on association rules*

Ding Xia1, Li Yuan2, Li Ping2, Su Zeqi3, Wu Fengzhi4, Chu Fuhao1, Gu Xiaohong1#   

  1. 1 School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
    3 Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
    4 Journal Center, Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2020-02-09 Published:2020-07-06
  • Contact: Prof. Gu Xiaohong, M.M., Chief Physician, Doctoral Supervisor. Beijing University of Chinese Medicine. No.11 Beisanhuan Donglu Road, Chaoyang District, Beijing 100029. E-mail: guxh1003@126.com
  • Supported by:
    National Key Research and Development Project, Ministry of Science and Technology (No. 2018YFC1704100, No. 2018YFC1704106)

Abstract: Objective To analyze the prescription characteristics of consensus formulae for the prevention and treatment of novel coronavirus pneumonia (NCP) also known as coronavirus disease 2019 (COVID-19) with traditional Chinese herbal medicine. Methods We collected the following formulae released from the start of NCP outbreak to February 6, 2020: foumulae in the “Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial)” (3rd to 5th ed.) issued jointly by the National Health Commission and the National Administration of Traditional Chinese Medicine of PRC; the latest clinically-proven effective prescription Qingfei Paidu Tang (Lung-clearing and Toxin-expelling Decoction) (February 6, 2020 ed.); formulae in the “Prevention and Treatment Protocol for Novel Coronavirus Pneumonia in Beijing” (1st and 2nd ed.) issued by the Beijing Municipal Administration of Traditional Chinese Medicine; prescriptions approved and released by varied health commissions, traditional Chinese medicine administrations and hospitals at provincial and municipal levels; and prescriptions made public by various medical schools and several prestigious doctors for the prevention and treatment of NCP. The R software (V 3.6.1) was used to analyze the frequency of occurrence of herbs and association rules in formulae for preventive and therapeutic purposes respectively. Results 107 preventive formulae involving 121 herbs were identified. 11 herbs with frequency of occurrence over 20% were Gancao (Licorice Root, Radix et Rhizoma Glycyrrhizae), Huangqi (Astragalus Root, Radix Astragali), Jinyinhua (Honeysuckle Flower, Flos Lonicerae Japonicae), Jiegeng (Platycodon Root, Radix Platycodonis), Lianqiao (Weeping Forsythia Capsule, Fructus Forsythiae), Cangzhu (Atractylodes Rhizome, Rhizoma Atractylodis), Fangfeng (Siler, Radix Saposhnikoviae), Baizhu (White Atractylodes Rhizome, Rhizoma Atractylodis Macrocephalae), Lugen (Reed Rhizome, Rhizoma Phragmitis), Guanghuoxiang (Cablin Patchouli, Herba Pogostemonis), and Sangye (Mulberry Leaf, Folium Mori). The core combinations of herbs included Huangqi, Gancao, Jinyinhua, Lianqiao, and Fangfeng according to association rules. There were 115 therapeutic prescriptions involving 203 herbs, of which the following 7 herbs were the most frequently used with frequency of occurrence over 20%: Gancao, Huangqin (Scutellaria Root, Radix Scutellariae), Shigao (Gypsum, Gypsum Fibrosum), Kuxingren (Bitter Apricot Kernel, Semen Armeniacae Amarum), Mahuang (Ephedra, Herba Ephedrae), Lianqiao, and Jinyinhua. The core combinations of herbs included Mahuang, Kuxingren, Shigao, and Gancao according to association rules. Conclusion For the prevention of NCP, the main method used seems to be boosting qi to consolidate the exterior, supplemented by clearing heat, resolving toxins and drying dampness. The commonly used formulae were Yupingfeng San (Jade Wind-Barrier Powder) and Yinqiao San (Lonicera and Forsythia Powder). For therapeutic purpose, clearing heat, resolving toxins, and drying dampness were the major methods adopted. The most frequently used prescription was Maxing Shigan Tang (Ephedra, Apricot Kernel, Gypsum and Licorice Decoction) plus Huangqin and Lianqiao. Treatment should vary according to the progression and stage of the disease with modifications based on complications.

Key words: novel coronavirus pneumonia, traditional Chinese herbal medicine, concensus formula, association rules, prescription characteristics

CLC Number: 

  • R272