主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2020, Vol. 43 ›› Issue (12): 973-979.doi: 10.3969/j.issn.1006-2157.2020.12.001

• Expert Opinion •     Next Articles

Challenges and solutions in the establishment of rat models of gastritis deteriorating into gastric carcinoma*

Ding Xia1, Su Zeqi2, Shen Hong3, Zhang Ping4   

  1. 1 School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Beijing Research Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
    3 Jiangsu Province Hospital of Chinese Medicine, Jiangsu 210029, China;
    4 Wang Jing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China
  • Received:2020-08-27 Online:2020-12-30 Published:2021-01-05
  • Contact: Prof.Ding Xia, Ph.D.,Doctoral Supervisor. School of Chinese Medicine,Beijing University of Chinese Medicine. No.11 Beisanhuan Donglu Road,Chaoyang District,Beijing 100029. E-mail: dingx@bucm.edu.cn
  • Supported by:
    National Natural Science Foundation of China (No. 81703931, No. 81630080)

Abstract: Since “deterioration of chronic gastritis into gastric cancer” is the main cause of gastric cancer, active prevention and treatment of such deterioration is of great significance for reducing the incidence of gastric cancer. However, many bottlenecks in model establishment have restricted the development of basic research and application in this field, e.g. the selection of model factors, model preparation methods, model evaluation at different pathological stages, the way of combining WM disease and TCM pattern in model establishment, and model pattern determination. Based on the research findings of the present team in the last 5 years as well as global research progress, problems in the establishment of the animal models of gastritis deteriorating into gastric carcinoma with consideration of both WM disease and TCM pattern were analyzed one by one and possible solutions were proposed. We simulated the clinical features of the multifactorial disease and provided two rat models with MNNG as the main factor. Compared with the existing models, they are proved more in line with clinical characteristics of the disease and yield higher success rates for model establishment and better stability by multiple experiments. They may become powerful tools for animal research in this field.

Key words: chronic gastritis, precancerous lesion, deterioration of gastritis into gastric cancer, animal model, combination of disease and pattern

CLC Number: 

  • R259.733