主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2020, Vol. 43 ›› Issue (12): 1053-1057.doi: 10.3969/j.issn.1006-2157.2020.12.013

• Clinical Studies • Previous Articles    

Clinical observation of 40 cases of Agkistrodon acutus bite treated with Lianhua Jiedu Tang*

Chen Jun1, Dong Degang1, Yan Zhangren2, Wang Wanchun2#, Yi Jun2, Mao Wenli2, Li Yanfang2, Wang Jiangang2, Zhang Naixin2, Liu Liang1, Wang Xi1   

  1. 1 Jiangxi University of Traditional Chinese Medicine, Jiangxi 330004, China;
    2 Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Jiangxi 330006, China
  • Received:2020-06-26 Online:2020-12-30 Published:2021-01-05
  • Contact: Prof.Wang Wanchun, Ph.D,Doctoral Supervisor. Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine. No.445 Bayi Road, Donghu District,Nanchang 330004. E-mail:1210569577@qq.com
  • Supported by:
    National Natural Science Foundation of China (No. 81360288), Science and Technology Support Program of Jiangxi Province (No. 20161BBG70108), Natural Science Foundation of Jiangxi Province (No. 20181BAB205074)

Abstract: Objective To observe the clinical effect of Lianhua Jiedu Tang (Bearded Scutellaria Toxin-removing Decoction, LHJDT) on Agkistrodon acutus bite. Methods 80 patients bitten by Agkistrodon acutus were randomly divided into control group and treatment group with 40 patients in each group. While the control group was given conventional Western medical treatment, patients in the treatment group took LHJDT orally in addition to the conventional treatment. During one-week treatment, the average recovery time, the time swelling, pain and ecchymosis took to subside, and the total scores of local symptoms and systemic signs of the two groups before and after treatment were measured and recorded; furthermore, the total effective rates of the two groups were compared. Results The total effective rates were 87.17% and 65.78% in the treatment and control groups respectively. There were significant differences between the two groups of patients in the average recovery time, the time swelling, pain and ecchymosis took to subside, and the total scores of local symptoms and systemic signs on Day 3 and Day 7 during the treatment course. The curative effect of the treatment group was better than that of the control group (P<0.05). Conclusion LHJDT can inhibit the activity of snake venom of Agkistrodon acutus with definite therapeutic effect, and further clinical application is needed.

Key words: Lianhua Jiedu Tang, agkistrodon acutus bite, local symptoms, systemic signs

CLC Number: 

  • R268