主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2021, Vol. 44 ›› Issue (1): 83-91.doi: 10.3969/j.issn.1006-2157.2021.01.012

• Clinical Studies • Previous Articles     Next Articles

Clinical effect of Xingpi Jieyu Formula on mild to moderate depression of liver depression and spleen deficiency pattern*

Li Yang1, Guo Rongjuan2#, Zhao Zhonghui3, Yu Yao3, Guo Jianyou4, Yuan Qingjie5   

  1. 1 Beijing Hospital of traditional Chinese Medicine Beijing 100010,China;
    2 Dongfang Hospital of Beijing University of traditional Chinese Medicine,Beijing 100078,China;
    3 Beijing University of traditional Chinese Medicine,Beijing 100029,China;
    4 Institute of psychology of Chinese Academy of Sciences,Beijing 100101,China;
    5 Yuquan Hospital of Tsinghua University,Beijing 100040,China
  • Received:2020-03-19 Online:2021-01-30 Published:2021-01-18
  • Contact: Prof.Guo Rongjuan,Chief physician,Doctoral supervisor,Dongfang Hospital,Beiing 100078.E-mail:dfguorongjuan@ 163.com.
  • Supported by:
    National Natural Science Foundation of China(No.81573843,No. 81874422).

Abstract: To study the effects of Xingpi Jieyu Formula on mild to moderate depression of liver depression and spleen deficiency pattern.Methods 61 patients with depression of liver depression and spleen deficiency pattern who volunteered to participate in the study from July 2018 to January 2019 were randomly divided into control group (30 cases) and experimental group (31 cases) according to the time sequence.The control group was treated with placebo (Xingpi Jieyu granule simulant) and the experimental group was treated with Xingpi Jieyu formula granules.Both groups took 1 dose daily and took separately in the morning and afternoon After 6 weeks of treatment,HAMD-24,HAMA,SDS,SAS,TCM syndrome factor scale scores of depression were compared between the two groups,and the changes of ATP,ADP,amp contents in peripheral blood of the two groups before and after treatment,as well as the occurrence of adverse reactions were compared.Results In terms of clinical efficacy:compared with before treatment,the total scores of HAMD-24,five factor scores of “anxiety/somatization,cognitive impairment,day and night change,block and sense of despair”,SDS score,qi deficiency and qi stagnation pattern scores were reduced in the control group (P<0.05);the total scores of HAMD-24,six factor scores,gastrointestinal and general symptoms,HAMA total scores,somatic and psychological scores,SDS score,SAS score,and pattern scores of qi deficiency,qi stagnation and phlegm dampness were significantly lower than those before treatment in the experimental group (P<0.05).The total effective rate of HAMD score was 93.55% (70.97% markedly effective).In terms of mechanism of action:compared with before treatment,peripheral serum AMP increased in the control group (P<0.05);ATP increased in the experimental group after treatment (P<0.05);in terms of safety profile,1 patient in control group had nausea,and 2 patients in the experimental group had nausea diarrhea.All symptoms disappeared on its own shortly (2-3 days).No cases of liver and kidney injury.Conclusion Compared with placebo,Xingpi Jieyu Formula could significantly improve depression and somatic symptoms of depressive patients,and can increase peripheral blood ATP level.

Key words: depression, liver depression and spleen deficiency syndrome, Xingpi Jieyu Formula, mitochondria, ATP

CLC Number: 

  • R229