主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2021, Vol. 44 ›› Issue (3): 215-220.doi: 10.3969/j.issn.1006-2157.2021.03.004

• Theoretical Studies • Previous Articles     Next Articles

Analysis of mechanism of inflammation-cancer transformation from damp-heat theory*

Tian Lin, Lin Cuili, Sun Yueming, Ke Xiao, Huang Minghan#, Yang Chunbo   

  1. The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fujian 350003, China
  • Received:2020-09-23 Online:2021-03-30 Published:2021-03-30
  • Contact: Associate Prof. Huang Minghan, Associate Chief Physician, Master Supervisor. The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine. No. 282 Wusi Road, Gulou District, Fuzhou 350003. E-mail: huangminghan2010@163.com
  • Supported by:
    National Key Research and Development Program of China -- Key Special Project of Research on Modernization of Traditional Chinese Medicine (No. 2018YFC1705402), National Natural Science Foundation of China (No. 81673731)

Abstract: Damp-heat is a common pathogenic factor clinically, which is characterized by stickiness and greasiness. Inflammatory cells and inflammatory mediators constitute the local inflammatory microenvironment. The formation, invasion and metastasis of tumors are based on the persistent existence of inflammatory microenvironment. The characteristic stickiness of damp-heat suggests that it may be an important factor for the persistent and refractory inflammatory microenvironment. At the same time, the transformation into toxin from dampness-heat pathogenic qi is similar to the inflammation-cancer transformation, and there is a close relationship between them. The main pathogenic substances of tumor, such as phlegm and stasis, are essentially from the source of damp-heat, which participates in the whole process of the inflammation-cancer deterioration as an initiating factor. Therefore, on the basis of analyzing the etiology and pathogenesis of inflammatory microenvironment, this paper discusses in-depth the pathological mechanism of the inflammation-cancer transformation from the perspective of the damp-heat theory, providing important theoretical basis for clinical diagnosis and treatment.

Key words: damp-heat theory, inflammation-cancer transformation, inflammatory microenvironment, pathogenic toxin

CLC Number: 

  • R246.5