主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2021, Vol. 44 ›› Issue (4): 350-357.doi: 10.3969/j.issn.1006-2157.2021.04.010

• Science & Technology • Previous Articles     Next Articles

Variation of pulse parameters in patients of primary dysmenorrhea with the pattern of cold congelation and blood stasis based on multi-temporal dynamic observation*

Yang Yingying, Wang Tianfang, Zhao Lihong#, Wang Yanping, Tang Ling, Li Ning, Li Xin, Zhang Wenzheng   

  1. Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2020-05-25 Published:2021-04-29
  • Contact: A/Prof. Zhao Lihong, Beijing University of Chinese Medicine, Beijing 102488. E-mail: lihongzhaolhz@163.com.
  • Supported by:
    National Natural Science Foundation for Young Scientists of China (No. 81703984)
    Ethical review: Medical and Experimental Animal Ethics Committee, Beijing University of Chinese Medicine (No. 2017BZHYLL0505)

Abstract: Objective To analyze the dynamic changes of pulse parameters and their correlation with pain degree in patients of primary dysmenorrhea (PD) with the pattern of cold congelation and blood stasis. Methods PD patients with the pattern of cold coagulation and blood stasis were the PD group and healthy subjects were the control group. Electroacupuncture treatment was administered at the typical onset of dysmenorrhea. Four observation points (T0-7~10 days before menstruation, T1-menstrual dysmenorrhea typical attack, T2-after the acupuncture analgesia treatment for 30 min immediately,T3-30 min after acupuncture analgesia treatment) were made. Pulse parameters were collected by using DS01-C pulse imager, including amplitude(h), time(t), width(w), amplitude ratio, time-figure ratio, width-to-time-fiure ratio, heart rate(HR)and so on, and the Visual Analogue Score (VAS) was evaluated to assess pain severih. Repeated measurement variance analysis, Pearson correlation coefficient, Spearman correlation coefficient and the descriptive statistics including mean and standard deviation were used in statistical analysis. Results A total of 35 PD patients and 32 healthy controls were included. In terms of pain severity, VAS at T1,T2 and T3 were all significantly higher than T0 (P<0.05) while the scores at T2 and T3 were all significantly lower than T1 (P<0.05). As for pulse parameters, compared with T0,h2,h4,t1 of T1 all increased significantly (P<0.05); compared with T1, t5 of T2 increased significantly (P<0.05) and h3/h1,w1,w1/t,t1/t,t1,HR all decreased significantly (P<0.05); compared with T2, h3/h1,w1/t,t1/t,t1of T3 all increased significantly (P<0.05). Compared with healthy controls at the same time: the h2,h4 of the syndrome of cold congelation and blood stasis were all significantly lower than those in the healthy control (P<0.05), the h3/h1,w1/t、t1,t1/t were all significantly higher (P<0.05) at the T1 (P<0.05); the t1,t1/t were all significantly higher (P<0.05) at the T3 (P<0.05). In the correlation between pulse chart parameters and pain degree, the pulse chart parameters that were positively correlated with the VAS were: h2,h3,h4,h3/h1,h4/h1,w1(P<0.05); negatively correlated: h5,h5/h1(P<0.05).Conclusion Pulse parameters in patients of PD with the pattern of cold congelation and blood stasis seem to change after the onset of pain and compared to the healthy population. The changes of the pulse parameters correlated with the severity of pain

Key words: pulse parameters, syndrome of cold congelation and blood stasis, primary dysmenorrhea

CLC Number: 

  • R241.1