主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2021, Vol. 44 ›› Issue (6): 496-499.doi: 10.3969/j.issn.1006-2157.2021.06.003

• Theoretical Studies • Previous Articles     Next Articles

Effects of the glymphatic system and the midnight-noon ebb-flow theory on adjustment of the circadian rhythm and the prevention and treatment of Alzheimer’s disease*

Diao Huaqiong1, Ding Haiyue1, Li Xiaoli1#, Chen Lin1, Wei Dan1, Zhang Jing1, Li Qianqian2, Lu Lihua1, Zhang Naiwen1, Li Mengyuan1   

  1. 1 Department of Encephalopathy, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China;
    2 Department of Acupuncture and Moxibustion, Beijing Hospital of TCM Affiliated to Capital Medical University, Beijing 100016, China
  • Received:2020-11-26 Online:2021-06-30 Published:2021-06-25
  • Contact: Prof. Li Xiaoli, Ph.D., Doctoral Supervisor. Beijing University of Chinese Medicine Third Affiliated Hospital. No.5 Xiaoguan Street, Andingmenwai, Chaoyang District, Beijing 100029. E-mail:tigerlxl2002@163.com
  • Supported by:
    National Natural Science Foundation of China (No. 81673930)

Abstract: Based on the holistic view of “correspondence between human beings and nature”, the midnight-noon ebb-flow theory holds that qi and blood flow in the twelve meridians in sequence with the waxing and waning of yin and yang at different hours of the day, which is correlative with the circadian rhythm. Glymphatic system, a flowing exchange system, which clears intracephalic metabolites, has an effect on the progression of Alzheimer’s disease. This article analyzes the application of the midnight-noon ebb-flow theory and lymphatic system in the prevention and treatment of Alzheimer’s disease and discovers that both affect the cognitive function through the circadian rhythm. Therefore, it is argued that “the midnight-noon ebb-flow theory may be used to adjust the circadian rhythm to improve the peak flow of the lymphatic system, promote β-amyloid metabolism and alleviate cognitive disorder”, which could provide reference for the prevention and treatment of Alzheimer’s disease with traditional Chinese medicine.

Key words: glymphatic system, midnight-noon ebb-flow, circadian rhythm, Alzheimer’s disease, β-amyloid

CLC Number: 

  • R224.3