主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE ›› 2021, Vol. 44 ›› Issue (6): 562-568.doi: 10.3969/j.issn.1006-2157.2021.06.012

• Acupuncture & Moxibustion • Previous Articles     Next Articles

Clinical observation of the cognitive function and intestinal microecology of patients with vascular dementia treated with Tiaoshen Yizhi acupuncture combined with Dingzhi Yicong Fang*

Yang Yuanqing, Li Si, Ji Xuequn, Zhang Ping, Yang Xiujuan, Zhang Zhilong#   

  1. Department of Acupuncture and Moxibustion, Tianjin Academy of TCM Affiliated Hospital, Tianjin 300120, China
  • Received:2020-12-16 Online:2021-06-30 Published:2021-06-25
  • Contact: Zhang Zhilong, Chief Physician, Doctoral Supervisor. Tianjin Academy of TCM Affiliated Hospital. No.354, Beima Road, Hongqiao District, Tianjin 300120. E-mail: zhangzhilongtj@163.com
  • Supported by:
    Project of Chinese Medicine, Integration of Chinese and Western Medicine, Tianjin Administration of TCM (No. 2019032)

Abstract: Objective To explore the effect of Tiaoshen Yizhi (Mind-regulating and Intelligence-improving, TSYZ) acupuncture combined with Dingzhi Yicong Fang (Mind-calming and Intelligence-improving Formula, DZYCF) on the mental state, cognitive function and intestinal microecology of patients with vascular dementia (VD). Methods 64 patients with vascular dementia who met the inclusion criteria were randomly divided into the observation group and the control group, 32 cases in each group. The observation group was treated with TSYZ acupuncture combined with DZYCF, and the control group was treated with donepezil hydrochloride for 60 days. The changes in MMSE, BBS, BI, cognitive scale of Alzheimer Disease Rating Scale (ADAS-Cog), TCM pattern scores and the numbers specific intestinal floras were assessed and analyzed before and after treatment. Results The total effective rates of the two groups were 84.38% and 62.50% with statistically significant difference (P<0.05). Compared with before treatment, the MMSE and BI scores and the numbers of floras of bifidobacterium, lactobacillus, peptococcus, saccharomycetes, and bacteroides increased, the numbers of floras of enterococcus, bacillus coli, and clostridium parvum and the BBS, ADAS-Cog and TCM pattern scores of both groups decreased after treatment (P<0.05, P<0.01). After treatment, compared with the control group, the MMSE and BI scores and the numbers of floras of bifidobacterium, lactobacillus, peptococcus, saccharomycetes, and bacteroides increased, the numbers of floras of enterococcus, bacillus coli, and clostridium parvum and the BBS, ADAS-Cog and TCM pattern scores of the observation group decreased (P<0.05, P<0.01). Conclusion TSYZ acupuncture combined with DZYCF can improve the mental state, cognitive function, social capability, daily life function, and TCM pattern of VD patients, and can effectively restore the balance of intestinal floras and maintain the stability of intestinal microecology. With better curative effect than conventional treatment using Western medicine, it could be a new way to treat VD clinically.

Key words: vascular dementia, Tiaoshen Yizhi acupuncture, Dingzhi Yicong Fang, intestinal flora, clinical research

CLC Number: 

  • R277.7