主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R
30 August 2020, Volume 43 Issue 8 Previous Issue   
Expert Review
Pandemic risk factor analysis of COVID-19 and inspirations from its prevention and control
Wang Yongyan, Wang Zhong, Bai Weiguo, Zhi Yingjie, Wang Yanping
2020, 43 (8):  621-622.  doi: 10.3969/j.issn.1006-2157.2020.08.001
Abstract ( 103 )   PDF (1316KB) ( 49 )  
In order to promote effective prevention and control of the pestilence by traditional Chinese medicine (TCM), it’s of great significance to explore the main ways of the pestilence epidemic. The most weighted epidemic factor is the environmental degradation. Thus, the application of the Yunqi Theory emphasizing “harmony between man and nature” into the prevention and treatment of the pestilence in clinic would be the best way to gain the common consent of the effect and the decrease of the mortality, which might be a good opportunity to show TCM contribution to the health of the human. Based on the standardization of the operation procedures, it’s further suggested that extraction of key elements in patterns of the disease should be viewed as a breakthrough, combined with various technologies from the network, block data and big data of biological blockchain, thus ushering in the third stage of Chinese epidemiology.
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Conception of life science from the perspective of Chinese medicine
Xu Anlong, Shi Yuanyuan, Lu Tao, Jiang Miao, Li Feng, Liu Jianping, Li Hongmei
2020, 43 (8):  623-629.  doi: 10.3969/j.issn.1006-2157.2020.08.002
Abstract ( 111 )   PDF (1214KB) ( 81 )  
The rise of modern life science has triggered a revolution in thinking and understanding of the essence of life academically. With the rapid development of modern science and technology, the modern biomedicine, represented by precision medicine and system biology, is constantly getting close to the holistic view of life cognition and the thought of the unity of man and nature in Chinese medicine. Although they belong to different academic thinking systems, with the assimilation and high quality of the global human demand for life care, the integration of Chinese medicine and Western medicine is the inevitable trend of future development. In order to promote this integration to be more orderly and quickly formed, this article attempts to propose a new disciplinary concept: Life Science From the Perspective of Chinese Medicine. This concept covers four major elements, namely, matter, energy, information and space-time. In order to promote the development of new medicine based on life science from the perspective of Chinese medicine, the combination point of life view of Chinese medicine and modern science is explored. The initial specific research directions are: the systematic material basis of Chinese medicine life concept, the energy, information, temporal and spatial changes under laws of Chinese medicine life concept, the intelligent training of Chinese medicine big data, and the development of medical engineering equipment for Chinese medicine life concept so that Chinese medicine can serve human health more effectively in the modern environment, realize the integration of Chinese and Western medicine under the framework of integration, and provide the basic support of life science for the establishment of new medicine.
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Theoretical Studies
Prevention and treatment strategy of COVID-19 from the perspective of TCM membrane system*
Yang Guannan, Jiang Xin, Gu Xiaohong
2020, 43 (8):  630-635.  doi: 10.3969/j.issn.1006-2157.2020.08.003
Abstract ( 84 )   PDF (1192KB) ( 36 )  
For COVID-19, there is currently limited effective therapeutic approach or antiviral drugs at present. According to traditional Chinese medicine (TCM), COVID-19 belongs to the category of “damp plague”, and it can be diagnosed and treated with distinctive pattern differentiation methods. However, its pathogenesis and transmission still needs further exploration. The TCM membrane system theory is a systematical summary of the understanding of “membrane” based on TCM ancient literature and modern medicine. The membrane system is distributed over all body cavities, connects the three jiao and covers all of the membrane-layered structures composed of connective tissue and epithelial tissue in the whole body. This system is regarded as the physiological pathway of qi, water and fire, as well as the pathological pathway of the pathogenic factors. It is believed that the damp-warm-heat pathogenic factors invade the membrane from the external mucosal membrane system of all orifices in the human body, and distribute inside of the body along the inner and outer membrane systems. The abnormality of membrane system is the core factor of the occurrence and transmission of the disease. On the base of such pathogenesis, it is proposed that the principle of prevention and treatment of COVID-19 should be defending the toxic pathogenic factors and dredging the membrane system so as to promote the elimination and excretion of pathogenic factors.
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Similarities and differences in thinking on tonifying the kidney between Zhu Zhenheng and Zhang Jiebin*
Xi Chongcheng, Tian Dong, Liu Jintao, Zhang Ning, Liu Zhenzhu, Wang Weiguang, Chen Zijie, Zhai Shuangqing
2020, 43 (8):  636-640.  doi: 10.3969/j.issn.1006-2157.2020.08.004
Abstract ( 80 )   PDF (1184KB) ( 44 )  
As one of the four great scholars in Jin and Yuan Dynasties, theory of Zhu Zhenheng(Zhu Danxi) has great influence on later generations. Zhang Jiebin studied Zhu Danxi’s theory in his early years. While criticizing and inheriting Zhu Zhenheng’s thought of nourishing yin, he became one of the representatives of the warm-nourishing school. Zhu Zhenheng and Zhang Jiebin both attach importance to supplementing kidney essence so as to tonify the kidney; in the selection of medicinals, medicinals from plants and animals are combined; besides, they both take pills as the main drug form. However, their thoughts differ in the following aspects. In warming and nourishing kidney yang, Zhu Zhenheng prefers to use moderate medicinals to generate qi without causing fire, while Zhang Jiebin prefers to use medicinals extremely pungent and heat in nature for quick effect. In nourishing kidney yin, Zhu Zhenheng advocates that yin-nourishing medicinals should be combined with bitter cold ones, then ministerial fire can be cleared; while Zhang Jiebin prefers to combine yin-nourishing, qi-supplementing and yang-warming medicinals to seek yin within yang. In Conclusion, Zhu Zhenheng’s and Zhang Jiebin’s thoughts on tonifying the kidney play a guiding role in the clinical treatment of various diseases with kidney deficiency pattern.
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Textual Research
Textual research on the dosage of Kai Xin San in Qian Jin Yao Fang*
Zhang Lin, Zeng Feng
2020, 43 (8):  641-644.  doi: 10.3969/j.issn.1006-2157.2020.08.005
Abstract ( 89 )   PDF (1126KB) ( 50 )  
With Kai Xin San (Joy Powder) in Directory of Famous Formula in Ancient Times as the study object, this paper explored the difference of the dosage in two different versions of Qian Jin Yao Fang (Important Formulas Worth a Thousand Gold Pieces): Song version and Xindiao version. In the textual research, we have taken the characteristics of the above two editions into consideration, and have compared the relevant record of other formulas in Song version. Also, we have referred to the relevant record in the contemporary book Yi Xin Fang as proof. It’s concluded that the original dosage of Kai Xin San (Joy Powder) should be “Four Fen (one Liang) of Yuanzhi (thin-leaf milkwort root, Radix Polygalae) and Renshen (ginseng, Radix et Rhizoma Ginseng) respectively, two Liang of Fuling (poria, Poria), and one Liang of Changpu (grassleaf sweetflag rhizome, Rhizoma Acori Tatarinowii)”. According to the research result on the medicine tool “Fang Qi Bi” in Research on the Original Dosage in Classical Formula, the dosage is converted to modern measuring unit: Yuanzhi (thin-leaf milkwort root, Radix Polygalae) 13.8 g, Renshen (ginseng, Radix et Rhizoma Ginseng) 13.8 g, Fuling (poria, Poria) 27.6 g; and Changpu (grassleaf sweetflag rhizome, Rhizoma Acori Tatarinowii) 13.8 g, and the daily administration should be Yuanzhi (thin-leaf milkwort root, Radix Polygalae) 3 g, Renshen (ginseng, Radix et Rhizoma Ginseng) 3 g, Fuling (poria, Poria) 6 g, and Changpu (grassleaf sweetflag rhizome, Rhizoma Acori Tatarinowii) 3 g.
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Chinese Medicinal Pharmacology
Protective effect and mechanism of chebulagic acid on H9C2 cells injury induced by aconitine*
Han Shu, Liu Shuai, Zhang Qiao, Zhi Meiru, Liu Kaiyang, Tang Ya’nan, Han Xitao, Liu Ziqin, Li Fei, Du Hong
2020, 43 (8):  645-652.  doi: 10.3969/j.issn.1006-2157.2020.08.006
Abstract ( 49 )   PDF (4056KB) ( 26 )  
Objective To investigate the toxicity of aconitine to H9C2 cells by HCA, and to further explore the effect of chebulagic acid, the active component of He Zi (medicine terminalia fruit, Fructus Chebulae), on the cardiotoxicity induced by aconitine, and to explore its mechanism in reducing the toxicity of He Zi (medicine terminalia fruit, Fructus Chebulae). Methods Different concentrations of aconitine, chebulagic acid and aconitine + chebulagic acid were used to act on H9C2 cells respectively. Hoechst 33258 and other fluorescent probes were used to dye the cells. HCA technology was used to detect and analyze the effects of drugs of different concentrations on the number of H9C2 cells, the area of nucleus, the DNA content of nucleus, the fluorescence intensity of Ca2+ and the influence on function of mitochondria. Results 10,20 μmol/L aconitine caused Ca2 + overload in cardiomyocytes; 20 μmol/L aconitine caused mitochondrial dysfunction of cardiomyocytes in varying degrees after acting on cardiomyocytes for 24 hours; 5,10,20 μmol/L chebulagic acid had no obvious toxicity when acting on H9C2 cells alone; 10,20 μmol/L of chebulagic acid combined with 20 μmol/L aconitine restored the mitochondrial function and significantly reduced the fluorescence intensity of Ca2+, compared with using aconitine alone. Compared with the control group, there was no significant difference between the two groups. Conclusions Aconitine causes calcium overload and mitochondrial dysfunction in cardiomyocytes, which may be the main cause of cardiotoxicity induced by aconitine. Chebulagic acid in He Zi (medicine terminalia fruit, Fructus Chebulae) seems to inhibit the Ca2 + overload induced by aconitine, improve the mitochondrial function, and detoxify aconitine.
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Regulation of input protein α3/NF-κB pathway by adjusting miR-181 with dissipating phlegm and removing blood stasis method and its anti-atherosclerosis mechanism*
Qin Hewei, Li Yanjie, Zhang Zhixin, Ji Lingshan, Guo Ning
2020, 43 (8):  653-660.  doi: 10.3969/j.issn.1006-2157.2020.08.007
Abstract ( 50 )   PDF (2238KB) ( 24 )  
Objective To observe the correlation between the anti-atherosclerosis mechanism of dissipating phlegm and removing blood stasis method and the effect on the input protein α3/NF-κB signaling pathway through the regulation of microribonucleic acid 181 (miR-181). Methods In vitro experiments, vascular endothelial cell injury model was established with oxidized low-density lipoprotein (ox-LDL). According to different intervention methods, cells were randomly divided into four groups: model group (blank serum), miR-181 mimic group, miR -181 inhibitor group, phlegm-resolving and blood stasis-eliminating TCM serum group (TCM serum group). After intervention, the cell activity of each group was detected. RT-PCR and Western blot were used to detect the mRNA and protein expression levels of miR-181, input protein α3 and NF-κB. In vivo experiments, 60 ApoE-/- mice were randomly divided into 5 groups: model group, miR-181 inhibitor group, miR-181 mimic group, high-dose and low-dose phlegm-resolving and blood stasis-eliminating TCM serum group (TCM high-dose serum group, and TCM low-dose serum group respectively) (n=12). After continuous intervention for 8 weeks, the plasma and aorta were collected for testing. The levels of IL-6, VCAM-1 and E-selectin in the peripheral plasma were tested by ELISA. The expression of microRNA-181, input protein α3 and NF-κB in the aortic wall of each group was tested by RT-PCR, and the pathological changes were observed. Results In vitro experiments, the cell activity of the TCM serum group and the miR-181 mimic group was significantly increased (P<0.05), and the expression of α3 and NF-κB mRNA were significantly down-regulated (P<0.05). In vivo experiments, compared with the model group, the plasma levels of IL-6, VCAM-1 and E-selectin in the TCM high-dose and low-dose serum groups and miR-181 mimic group were significantly lower, compared with the model group (P<0.05); compared with the inhibitor group, the levels of peripheral plasma IL-6, VCAM-1 and E-selectin in the TCM serum group were lower (P<0.05). Compared with the model group, the mRNA expression of aortic miR-181 in the TCM high-dose and low-dose serum groups and miR-181 mimic group was significantly increased (P<0.05), and the expression level of α3 and NF-κB significantly down-regulated (P<0.05). There was no significant difference in the indexes between the TCM high-dose and low-dose serum groups (P>0.05). Conclusion The anti-atherosclerosis mechanism of resolving phlegm and eliminating blood stasis may be related to the targeted regulation of miR-181 to affect the input protein α3/NF-κB signaling pathway, which could possibly reduce the levels of inflammatory mediators such as IL-6, VCAM-1 and E-selectin, thus reducing the damage of vascular endothelial cells.
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Effect of Yiqi Yangxue Shugan Formula on glutamate-induced RGC-5 cell injury model *
Li Tiantian, Zhou Jian, Yan Xiaoling, Su Yan, Zhou Xiaoyu, Wei Qiping
2020, 43 (8):  661-667.  doi: 10.3969/j.issn.1006-2157.2020.08.008
Abstract ( 52 )   PDF (2234KB) ( 23 )  
Objective To evaluate the effect of Yiqi Yangxue Shugan Formula (also known as Qing Mang Yi Hao Formula, QMYH) on inhibiting apoptosis of RGC-5 cells by detecting the apoptosis rate in RGC-5 glutamate-induced injury model and related mechanism. Methods Staurosporine (STSN) was used to differentiate RGC-5 cells in vitro. Sodium L-glutamate was used to establish RGC-5 cell apoptosis model, and the cell culture medium containing QMYH serum was used for intervention. CCK-8 Kit was used to detect the survival rate of RGC-5 cells in each group; flow cytometry was used to detect the apoptosis rate of cells in each group; Western-blot was used to analyze the expression levels of Bcl-2/Bax signaling pathway-related proteins in RGC-5 cells; RT-PCR detected the mRNA expression levels of Bcl-2 and Bax. Results Intervention with 0.125 μmol/L STSN medium for 1 h could induce RGC-5 neuronal differentiation. 8 mmol/L sodium L-glutamate interfering for 18 h could cause 50% of RGC-5 cells injury. The medium-dose QMYH group (5% QMYH group) had the highest survival rate of RGC-5 cells (51.1%) and the lowest apoptosis rate (3.9%); compared with the low-dose and high-dose QMYH groups, the mRNA expression level of Bcl-2 in the middle-dose group was obviously up-regulated (P> 0.05); in addition, the protein Bcl-2/Bax ratio increased significantly. Conclusion The 5% QMYH serum could possibly inhibit the apoptosis of RGC-5 cells by regulating the Bcl-2/Bax signaling pathway.
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Effect of Dahuang (rhubarb) Granule on intestinal microecological changes in rats with chronic renal failure*
Luo Xuewen, Zeng Yuqun, Wang Shiqi, Zou Chuan, Pi Chiheng
2020, 43 (8):  668-674.  doi: 10.3969/j.issn.1006-2157.2020.08.009
Abstract ( 50 )   PDF (1546KB) ( 25 )  
Objective To explore the effect of Dahuang (rhubarb) Granule on intestinal microecological changes in rats with chronic renal failure. Methods The 5/6 nephrectomy model was used as chronic renal failure model, and randomly divided into sham operation group, model group, and low-dose, medium-dose, high-dose Dahuang (rhubarb) Granule groups. After 4 weeks, the body weight, blood urea nitrogen (BUN), and blood creatinine (Crea) levels of each group were measured. Four key intestinal bacteria (including E.coli, Enteroroccus, Lactobacillus and Bifidbacteria) were cultured and quantified with the real-time qPCR method. Expression of colonic proteins claudin-1 and occluding was detected with immunohistochemical method. Indole sulfate (IS) and lipopolysaccharide (LPS) levels were detected with liquid chromatography-mass spectrometry and LPS Reagent method. Results Compared with the sham operation group, in the model group renal function indexes of blood urea nitrogen (BUN) and blood creatinine (Crea) were significantly increased (P>0.05); the pathogenic bacteria E.coli and Enteroroccus were significantly increased in the model group (P>0.05), and the probiotics Bifidbacteria was significantly reduced (P>0.05); the levels of claudin-1 and occludin in the colonic epithelium were significantly reduced; the serum IS and LPS levels were significantly increased (P<0.05). Compared with the model group, in the low-dose, medium-dose and high-dose Dahuang (rhubarb) Granule groups, the levels of BUN and Crea were significantly reduced (P>0.05); in the high-dose group, the number of E.coli and Enteroroccus was reduced (P<0.05), while the amount of Bifidbacteria was significantly increased (P<0.05); the expression of claudin-1 and occludin in colonic epithelium was significantly increased in all Dahuang (rhubarb) Granule groups (P<0.05); IS and LPS levels were significantly decreased in the medium-dose and high-dose Dahuang (rhubarb) Granule groups (P<0.05). Conclusion Dahuang (rhubarb) Granule seems to regulate the intestinal microecology in rats with chronic renal failure through regulating the intestinal flora, including increasing the probiotic Bifidbacteria and reducing the pathogenic bacteria E.coli and Enteroroccus, increasing the expression of intestinal mucosal compact proteins claudin-1, occludin, and reducing intestinal toxin IS and endotoxin LPS levels, which potentially improves renal function in rats with chronic renal failure.
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Mechanism of Majie Decoction against allergic rhinitis based on network pharmacology and preliminary verification*
Wu Jinyang, Zhang Boran, Zhang Yuteng, Zhang Hongchun
2020, 43 (8):  675-679.  doi: 10.3969/j.issn.1006-2157.2020.08.010
Abstract ( 89 )   PDF (2179KB) ( 118 )  
Objective To study the mechanism of Majie Decoction (Ephedra and White Mustard Seed Decoction) against allergic rhinitis based on network pharmacology and preliminarily verify it through in vivo experiments in mice. Methods Effective constituents of Majie Decoction (Ephedra and White Mustard Seed Decoction) were selected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP database) based on threshold of oral availability (OB) and drug-likeness (DL). Then corresponding targets of the selected constituents were obtained to form an effective constituents-targets network Targets relevant to allergic rhinitis were achieved based on Digsee database. The intersection dataset of these datasets was analyzed. Then the protein-protein reaction and its effect on the KEGG/Reactome pathway were analyzed based on String database. IL-4 signal pathway were verified by mouse model.Results 53 unduplicated effective constituents, including neobaicalein, panicolin, and 34 important targets against allergic rhinitis, including ESR1, AR, PPARG, PTGS2, DPP4, were obtained. The protein interaction network and enrichment analyses showed that targets of Majie Decoction (Ephedra and White Mustard Seed Decoction) are enriched in various inflammatory factor-related pathways. Animal experiments showed that Majie Decoction (Ephedra and White Mustard Seed Decoction) significantly reduced the levels of serum IgE, histamine and IL-4 in mice with allergic rhinitis. Conclusion The main mechanism of Majie Decoction (Ephedra and White Mustard Seed Decoction) may be relevant to regulation of multiple inflammatory factor-related pathways, especially IL-4 and IL-13.
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Science & Technology Theme
Effects of Houshiheisan Formula on the recovery of neurovascular function in rats with cerebral ischemia based on MRI*
Cheng Hongfa, Wang Xuan, Zhang Yawen, Zhao Hui, Wang Lei, Zou Haiyan, Zhang Qiuxia
2020, 43 (8):  680-688.  doi: 10.3969/j.issn.1006-2157.2020.08.011
Abstract ( 37 )   PDF (3284KB) ( 29 )  
Objective To non-invasively assess the therapeutic effect of Houshiheisan (HSHS) Formula on the recovery of neurovascular function after cerebral ischemia in rats with application of magnetic resonance imaging (MRI). Methods Focal cerebral ischemia model was induced by permanent middle cerebral artery occlusion (pMCAO) in male sprague-Dawley (SD) rats. Then the rats were randomly divided into 5 groups: sham group, model group, HSHS low-dose group (5.25 g/kg), HSHS high-dose group (10.50 g/kg) and Ginkgo biloba extract group (28 mg/kg). Nurological score was assessed after surgery to evaluate the degree of nervous function defects. T2 weighted imaging (T2WI) and T2 relaxation imaging were used to measure the volume of cerebral infarction and the degree of brain tissue damage in rats with cerebral ischemia. Arterial spin labeled perfusion weighted imaging(ASL-PWI)and magnetic resonance angiography (MRA) were used to evaluate the hemodynamic changes of intracranial vessels. Results Compared with the model group, HSHS high-dose group and Ginkgo biloba extract group decrease neurological function score on the 5th and 7th day (P<0.05). Compared with the model group, the infarct volume reduced and the damage of white matter and gray matter was decreased, and the cerebral blood flow and signal intensity of ischemic hemisphere increased in all treatment groups (P<0.05). Compared with the sham group, the cerebral blood flow and signal intensity of ischemic hemisphere decreased in the model group (P<0.01). Conclusion HSHS seems to alleviate brain injury and improve the intracranial hemodynamics, and promote the recovery of neurovascular function.
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Clinical Studies
Correlation between phlegm pattern of metabolic syndrome, fat mass and obesity-associated (FTO) gene*
Li Yuanyuan, Zhang Ping, Xu Chaoqiang, Li Dan, Chen Shujiao, Gao Bizhen
2020, 43 (8):  689-695.  doi: 10.3969/j.issn.1006-2157.2020.08.012
Abstract ( 46 )   PDF (1229KB) ( 30 )  
Objective To analyze the expression of fat mass and obesity-associated (FTO) genes in the peripheral blood of patients with phlegm pattern of metabolic syndrome (MS) and non-phlegm syndrome, and its correlation with elements and physicochemical index of phlegm pattern, so as to explore the genetic basis of MS phlegm pattern, and provide microcosmic index for the TCM diagnosis of MS phlegm pattern. Methods According to the method of “element-based pattern differentiation”, MS patients were divided into phlegm pattern group and non-phlegm pattern group (n=35), and 35 healthy people were recruited as the control group. The peripheral venous blood was collected for biochemical examination, and the expression of FTO gene mRNA and protein in human whole blood and serum were detected by real-time fluorescence quantitative PCR (probe method) and enzyme-linked immunosorbent assay (ELISA) method respectively. Results ① The relative expressions of FTO mRNA from high to low were phlegm pattern group > non-phlegm pattern group > control group, and the difference between the three groups was statistically significant (P<0.05); ② The expressions of FTO protein from high to low were control group > non-phlegm pattern group > phlegm pattern group, and the difference between the three groups was statistically significant (P<0.05); ③ The uric acid (UA) and BMI in the phlegm syndrome group were positively correlated with the score of phlegm pattern elements (P<0.05, P<0.01), and the alanine transaminase (ALT) in the non-phlegm pattern group was positively correlated with the score of phlegm pattern elements (P<0.01); ④ FTO mRNA expression was positively correlated with low-density lipoprotein (LDL-C) in the phlegm pattern group (P<0.05), positively correlated with aspartate aminotransferase (AST) in the non-phlegm pattern group (P<0.01). FTO mRNA expression was negatively correlated with Urea nitrogen (BUN) in the non-phlegm pattern group (P<0.05), and negatively correlated with LDL-C in the phlegm pattern group (P<0.05). Conclusion The high expression of FTO gene mRNA may increase the risk of phlegm pattern formation in MS. The concentrations of UA, BMI and LDL-C in the phlegm pattern group and the concentrations of ALT, AST and BUN in the non-phlegm pattern group may be related to the high expression of FTO gene. FTO gene could possibly be used as an auxiliary indicator for the diagnosis of phlegm pattern.
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TCM constitution types of gestational diabetes mellitus and their correlation to complications during pregnancy and childbirth*
Wang Jingshang, Wu Ying, Liu Xiaowei, Li Yuan, Guo Cuimei, Wu Ying, Yin Xiaodan, Li Xianrui, He Junqin
2020, 43 (8):  696-701.  doi: 10.3969/j.issn.1006-2157.2020.08.013
Abstract ( 57 )   PDF (1149KB) ( 19 )  
Objective To observe the TCM constitution types of gestational diabetes mellitus (GDM), and their correlation to complications during pregnancy and childbirth. Methods 144 cases who took routine pregnancy check-up in Beijing Obstetrics and Gynecology Hospital, Capital Medical University, were enrolled, including GDM group and control group (no pregnancy complications) (n=72). The levels of fasting blood glucose (FBG), glycosylated hemoglobin (HBA1c) and glycosylated serum protein (GSP) were measured on enrollment. The TCM constitution identification was done on enrollment and before delivery. The occurrence of complications during pregnancy and childbirth were recorded. Results The levels of FBG, HBA1c and GSP in the GDM group were significantly higher than those in the control group (P<0.01). The proportion of biased constitutions in the GDM group was significantly higher than that in the control group (P<0.01). On enrollment, the most common TCM constitution types in the GDM group were Yin Deficiency Constitution and Phlegm-Dampness constitution, accounting for 27.78% and 20.83% respectively. Before delivery, the proportion of Yin Deficiency Constitution and Phlegm-Dampness Constitution in the GDM group were 26.4% and 18.1% respectively. The incidence of complications during pregnancy and delivery in the GDM group was significantly higher than that in control group (P<0.05). Yin Deficiency, Qi Deficiency, Dampness-Heat and Phlegm-Dampness were the four constitution types with the highest incidence of complications during pregnancy and childbirth in the GDM group, which were significantly higher than those in the control group. In the GDM group, the complications rates ofthe Yin Deficiency Constitution were all higher than that of Balanced Constitution(P<0.05). Conclusion Patients with GDM seem to be more likely to have biased constitution types, especially Yin Deficiency and Phlegm-Dampness Constitutions. Meanwhile the incidence of complications during pregnancy and perinatal period in GDM patients with Yin dificiency Constitution seems to be higher than those with a Balanced Constitution. The study provides clinical reference for early prevention and treatment.
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New insights into TCM pattern differentiation and treatment of sound abnormality after thyroid surgery*
Li Lijing, Peng Jing, Cao Lishuang, Xia Zhongyuan
2020, 43 (8):  702-705.  doi: 10.3969/j.issn.1006-2157.2020.08.014
Abstract ( 52 )   PDF (1176KB) ( 39 )  
Abnormal sound is a common complication after thyroid surgery. At present, there is no consensus on the TCM pattern differentiation or treatment methods. In this paper, it is proposed that such a disorder is caused by recurrent laryngeal nerve injury, different from “throat dysphonia” in traditional understanding. The main etiology and pathogenesis in TCM are interpreted as channel damage in the neck resulting in stasis blocking the throat and malnourishment of the vocal tract. According to the characteristics of its clinical manifestations, it can be divided into patterns of wind-heat-phlegm accumulation, qi-yin deficiency, qi stagnation, and stasis blocking the throat. On the basis of pattern differentiation, prescriptions and medicinals should be selected according to the characteristics of the specific condition, aiming at dissolving stagnation and stasis, activating blood and unblocking channels. The specialized medicinals to promote sound generation can be divided into diffusing and lung-astringing ones, and used according to the duration of the illness.
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