主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R
30 June 2021, Volume 44 Issue 6 Previous Issue   
Theoretical Studies
Analysis of the properties of ancient aromatic Chinese herbs and the application of the theory of “aromatics acting on the spleen” in Huangdi Neijing*
Huang Hsunying, Liu Zhenzhu, Wang Weiguang, Zhai Shuangqing
2021, 44 (6):  485-490.  doi: 10.3969/j.issn.1006-2157.2021.06.001
Abstract ( 111 )   PDF (749KB) ( 209 )  
The theory that aromatic medicinals act upon the spleen was first put forward in Huangdi Neijing (Huangdi’s Internal Classic). It was believed that aroma primarily acted upon the spleen, so aromatic herbs also had a special regulatory effect on the spleen. In this paper, through classifying commonly used aromatic herbs recorded in ancient books on Chinese materia medica, and making statistical analysis of their nature, taste, meridian tropism and efficacy, we further explored the medicinal characteristics of aromatic herbs and their special effects on the spleen. Statistical results show that most aromatic herbs are warm in nature, and pungent and bitter in taste, and they enter primarily the spleen meridian, and secondarily the liver meridian. In terms of efficacy in modern Chinese materia medica, such herbs serve mostly to rectify qi, invigorate blood, dissolve stasis and dissipate wind-cold. It can be seen that aromatic medicinals do primarily act upon the spleen, and their effects are not limited to resolving dampness and inducing resuscitation. In addition, their pungent taste have dispersing and moving effects, their bitter taste can dry dampness, and their warm nature can raise yang. As pungent medicinals open and bitter medicinals direct things downward, aromatics are especially conducive to restoring spleen and stomach’s physiological function of raising the clear and directing the turbid downward, and then maintaining the qi circulation in the five zang and six fu organs. Therefore, the authors argue that the spleen must have played an important role in aromatic herbs’ clinical application to remove dampness and awaken the spleen and even to open the orifices and resuscitate, which also provides pharmacological evidence for the theory that aromatic medicinals act upon the spleen in Huangdi Neijing.
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Discussion of the category that skeletal muscle belongs to based on Huangdi Neijing*
LAI YE YANG, Li Nan
2021, 44 (6):  491-495.  doi: 10.3969/j.issn.1006-2157.2021.06.002
Abstract ( 82 )   PDF (668KB) ( 49 )  
Emphasis on both sinews and bones is an important guiding principle in the diagnosis and treatment of orthopedics and traumatology in traditional Chinese medicine. However, even until today, no consensus has been reached on the anatomical nature of sinews as different scholars explain its essence from different angles. The present authors believe that one of the controversies lies in skeletal muscle. Most of the time it is regarded as sinew in TCM because of its motor function. If that be the case, then the flesh of five body constituents in TCM would fail to correspond to any anatomical structure. Therefore, based on the physiological and pathological descriptions of sinew and flesh in Huangdi Neijing (Huangdi’s Internal Classic), this paper discusses the TCM category to which skeletal muscle belongs from the perspective of diagnosis and treatment of diseases. Finally, it is concluded that skeletal muscle falls into the category of muscle tissue. In terms of form, it belongs to the category of flesh and in terms of motor function, it belongs to the category of sinew. It is hoped that this understanding can complement the theory of sinews and bones and provide reference for clinical application.
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Effects of the glymphatic system and the midnight-noon ebb-flow theory on adjustment of the circadian rhythm and the prevention and treatment of Alzheimer’s disease*
Diao Huaqiong, Ding Haiyue, Li Xiaoli, Chen Lin, Wei Dan, Zhang Jing, Li Qianqian, Lu Lihua, Zhang Naiwen, Li Mengyuan
2021, 44 (6):  496-499.  doi: 10.3969/j.issn.1006-2157.2021.06.003
Abstract ( 59 )   PDF (559KB) ( 43 )  
Based on the holistic view of “correspondence between human beings and nature”, the midnight-noon ebb-flow theory holds that qi and blood flow in the twelve meridians in sequence with the waxing and waning of yin and yang at different hours of the day, which is correlative with the circadian rhythm. Glymphatic system, a flowing exchange system, which clears intracephalic metabolites, has an effect on the progression of Alzheimer’s disease. This article analyzes the application of the midnight-noon ebb-flow theory and lymphatic system in the prevention and treatment of Alzheimer’s disease and discovers that both affect the cognitive function through the circadian rhythm. Therefore, it is argued that “the midnight-noon ebb-flow theory may be used to adjust the circadian rhythm to improve the peak flow of the lymphatic system, promote β-amyloid metabolism and alleviate cognitive disorder”, which could provide reference for the prevention and treatment of Alzheimer’s disease with traditional Chinese medicine.
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Chinese Medicinal Pharmacology
Effects of Buyang Huanwu Tang on promoting the microstructural remodeling of brain tissue in rats with cerebral ischemia*
Feng Xuefeng, Li Manzhong, Zhan Yu, Yang Le, Lu Yun, Li Mingcong, Zhao Hui
2021, 44 (6):  500-509.  doi: 10.3969/j.issn.1006-2157.2021.06.004
Abstract ( 47 )   PDF (3185KB) ( 30 )  
Objective To observe the pharmacological effects and mechanism of Buyang Huanwu Tang (Yang-Supplementing and Five-Returning Decoction, BYHWT) on improving cerebral perfusion, protecting nerve cells and promoting axon growth and microstructure remodeling in rats with cerebral ischemia. Methods Cerebral ischemia model was induced by right middle cerebral artery occlusion. Male SD rats were randomly divided into sham group, model group and BYHWT group. The BYHWT group received 16.1 g/kg of BYHWT by gavage while the other two groups received the same amount of normal saline for 15 consecutive days, after which tissues were taken and examined. T2-weighted imaging (T2WI), arterial spin labeling (ASL) and diffusion tensor imaging (DTI) were applied to measure the infarct volume, analyze the changes in cerebral perfusion and detect the ultrastructure of the damaged brain region in cerebral ischemia rats respectively. Haematoxylin-eosin(HE) staining was used to observe the pathological damage of the injured brain region, immunofluorescence (IF) staining to detect expression levels of amyloid precursor protein (APP), NogoA and Nogo receptor (NgR), and real-time PCR (RT-RCR) to detect gene levels of NogoA and NgR and growth associated protein-43 (GAP-43) in order to evaluate axon growth and injury in rats with cerebral ischemia. Results MRI results revealed the BYHWT group had decreased infarct volume, increased cerebral perfusion of the infarcted core and peripheral cortex, and improved ultrastructure of periinfarct cortex, compared with the model group (P<0.05). HE staining showed the number of normal cortical neurons was increased while the number of abnormal neurons was decreased (P<0.01 or P<0.05), the degree of edema was reduced, and the density of nerve fibers was increased in the BYHWT group. According to IF staining results, compared with the model group, BYHWT group showed reduced positive expression of APP and NogoA in infarcted peripheral cortex and internal capsule (P<0.05 or P<0.01), and decreased positive expression of NgR in internal capsule(P<0.05). RT-PCR results indicated that BYHWT reduced gene expression levels of NogoA and NgR in peripheral tissue of infarct in the cerebral ischemia rats (P<0.05 or P<0.01). Conclusion BYHWT can effectively reduce the infarct volume, improve cerebral perfusion and brain ultrastructure, reduce nerve cell injury, promote axon growth and microstructural remodeling in rats with cerebral ischemia.
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Promotion of kidney-tonifying therapy on maturation of mouse oocyte in vitro based on PI3K/AKT/mTOR signaling pathway*
Tong Xue, Liang Xiao, Su Zi, Yan Mengxuan, Duan Yancang
2021, 44 (6):  510-518.  doi: 10.3969/j.issn.1006-2157.2021.06.005
Abstract ( 46 )   PDF (2355KB) ( 34 )  
Objective To explore the promotion of kidney-tonifying therapy on maturation of oocyte invitro and its relationship with PI3K/AKT/mTOR signaling pathways. Methods Female rats(6-8 weeks old) were given Bushen Tiaojing Fang Ⅲ (Kidney-tonifying Menstruation-regulating Formulas Ⅲ, BSTJF Ⅲ) to prepare serum containing BSTJF Ⅲ. Female mice (3-4 weeks old) were randomly divided into two groups: Group A and Group B. The two groups were given distilled water and a series of BSTJFs(BSTJF Ⅱ and BSTJF Ⅲ) by gavage respectively for 12 days. On the 11th day, all the mice were intraperitoneally injected with 5 IU of gonadotropin each and 48 hours later, the ovaries were removed and cumulus-oocyte complexes(COCs) were taken out for in vitro culture. COCs of Group A were divided into the blank control group and the inhibitor group (25 μmol/L of LY294002), and those of Group B were divided into the kidney-tonifying group (serum containing 10% of BSTJF Ⅲ) and kidney-tonifying + inhibitor group (serum containing 10% of BSTJF Ⅲ+25 μmol/L of LY294002). After 18 hours of culture in vitro, the number of discharged first polar bodies of the two groups were counted under microscope and the discharge rates were calculated. Real-time fluorescence quantitative PCR (RT-PCR) was used to detect the expressions of mRNA of Bcl-2, Bax, PI3K, AKT and mTOR in COCs of all groups. Immunofluorescence staining was used to detect the expressions of Bcl-2, Bax, PI3K, AKT, mTOR, p-PI3K, p-AKT and p-mTOR proteins in COCs of all groups. Results The first polar body discharge rate in the kidney-tonifying group was higher than that in the blank control group (P<0.05), that of the inhibitor group was lower than that of the blank control group (P<0.05), and that of the kidney-tonifying+inhibitor group was lower than that of the kidney-tonifying group (P<0.05). RT-PCR results showed that compared with the blank control group, the expressions of mRNA of Bcl-2, PI3K, AKT, and mTOR and Bcl-2/Bax of COCs increased (P<0.05) and the expressions of Bax mRNA decreased (P<0.05) in the kidney-tonifying group and the expressions of mRNA of Bcl-2, PI3K, AKT, and mTOR and Bcl-2/Bax of COCs decreased (P<0.05) and the expressions of Bax mRNA increased (P<0.05) in the inhibitor group. Compared with the kidney-tonifying group, the expressions of mRNA of Bcl-2, PI3K, AKT, and mTOR and Bcl-2/Bax of COCs decreased (P<0.05), and the expressions of Bax mRNA increased (P<0.05) in the kidney-tonifying+inhibitor group. Immunofluorescence staining results showed that there was no significant difference in the expressions of total protein of PI3K, AKT, and mTOR between the groups (P>0.05). Compared with the blank control group, the expression of Bcl-2 protein, p-PI3K/PI3K, and p-AKT/AKT of COCs increased (P<0.05) while the expression of Bax protein was decreased (P<0.05) in the kidney-tonifying group, and the expression of Bcl-2 protein, p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR of COCs decreased (P<0.05 ) while the expression of Bax protein was increased (P<0.05) in the inhibitor group. Compared with the kidney-tonifying group, the expression of Bcl-2 protein, p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR of COCs decreased (P<0.05) and Bax protein expression increased (P<0.05) in the kidney-tonifying+inhibitor group. Conclusion BSTJFs can promote mouse oocyte maturation by regulating the PI3K/AKT/mTOR signaling pathways, up-regulating the mRNA and ratio of protein expressions of Bcl-2 and Bax, and inhibiting granulosa cell apoptosis.
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Science & Technology Theme
Study on the expression levels of Ghrelin/GHSR-1a/GABA pathway key factors in models of gastroesophageal reflux disease with liver constraint pattern*
Chen Dongxue, Qian Zhanhong, Xia Congyuan, Ma Ru, Xu Yuan, Zhang Liying
2021, 44 (6):  519-526.  doi: 10.3969/j.issn.1006-2157.2021.06.006
Abstract ( 39 )   PDF (2642KB) ( 22 )  
Objective To investigate the expression levels of Ghrelin/GHSR-1a/GABA pathway key factors in rat model of gastroesophageal reflux disease (GERD) with liver constraint pattern. Methods 55 SD rats were randomly divided into the normal group, sham operation group, GERD group, liver constraint pattern group, and GERD with liver constraint pattern group, with 11 rats in each group. The GERD models were established by esophagogastroduodenal anastomosis (EGDA), the liver constraint pattern models were established by chronic unpredictable stimulation (CUS), and the GERD with liver constraint pattern models were established by EGDA combined with CUS. Sucrose preference test, open field test, and HE pathological observation of esophageal epithelium were performed. Ghrelin levels in serum and gastric tissue, GABA and GHSR-1a expressions in the hypothalamus was detected. Results Compared with the normal group and the GERD group respectively, the sucrose preference percentage and the total number of grids crossed (P<0.01) and the time spent in the central zone (P<0.01) by the GERD with liver constraint pattern group in the open field test were reduced, and the content of Ghrelin in the serum (P<0.01), the expressions of Ghrelin positive cells in the gastric tissue, and the expressions of GHSR-1a protein in the hypothalamus (P<0.01) were increased. Compared with the sham operation group, the contents of GABA in the hypothalamus of rats in the GERD with liver constraint pattern group were reduced (P<0.05). Conclusion EGDA combined with CUS can successfully establish the GERD with liver constraint pattern models. The expressions of the Ghrelin in the serum and gastric tissue and the GHSR-1a protein in the hypothalamus in the rat models may increase while the contents of GABA may decrease.
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TCM Informatics
Study on the pattern-treatment-medicinal correspondence and its evolution in 2,826 patients with type 2 diabetes*
Xing Ying, Pi Min, Zhang Runshun, He Xiong, Yang Jie, Wen Tiancai
2021, 44 (6):  527-537.  doi: 10.3969/j.issn.1006-2157.2021.06.007
Abstract ( 44 )   PDF (5278KB) ( 20 )  
Objective To analyze the pattern-treatment-medicinal correspondence and its evolution over time in patients with type 2 diabetes (T2DM) to provide reference for the clinical treatment of type 2 diabetes. Methods Complex network community discovery algorithm, directed weighted complex network, Sankey graph and core network analysis were used to conduct data mining on the electronic case data of 2,826 patients with T2DM to identify the temporal evolution of patterns and the core combination of Chinese herbal medicinals corresponding to different treatment plans. Results 49.5% of the patients were male and 50.5% female. 51.59% were aged from 41 to 60. 92.75% visited the clinic twice to 10 times. The complex network of pattern and treatment of T2DM were divided into 7 core pattern communities and 5 treatment communities. The top two communities that occupy the largest proportion were the qi-deficiency blood-stasis yin-yang-deficiency pattern community (26.84%) and the yin-enriching heat-clearing dampness-dispelling phlegm-dissolving treatment community (33.33%). The results showed that the sum of the number of visits by T2DM patients receiving yin-enriching heat-clearing dampness-dispelling phlegm-dissolving treatment and qi-moving blood-invigorating stasis-dissolving collateral-unblocking treatment in any pattern community before and after treatment accounted for more than 50% of the total. No matter what treatment method was adopted for any type of pattern, the pattern did not change in short term in about 50% patient visits, followed by those with patterns turning into the qi-deficiency blood-stasis yin-yang-deficiency pattern. The long-term evolution of the pattern-treatment relationship in patients with T2DM showed that most patterns remained the same after long-term treatment while a considerable amount turned into qi-deficiency blood-stasis yin-yang-deficiency pattern, spleen-deficiency stomach-heat liver-qi-stagnation pattern, and yin-deficiency effulgent-fire phlegm-heat-binding pattern. The medicinals used corresponded perfectly to the treatment communities. The commonly used combination of Chinese medicinal herbs included Huangqin (Scutellaria Root, Radix Scutellariae)-Huanglian (Golden Thread, Rhizoma Coptidis), Huanglian-Huangbai (Amur Cork-tree Bark, Cortex Phellodendri Chinensis), Huangqi (Milk-vetch Root, Radix Astragali)-Baishao (White Peony Root, Radix Paeoniae Alba), and Huanglian-Ganjiang (Dried Ginger Rhizome, Rhizoma Zingiberis). Conclusion The yin-enriching heat-clearing dampness-dispelling phlegm-dissolving treatment and qi-moving blood-invigorating stasis-dissolving collateral-unblocking treatment and Chinese herbal medicinals with the above mentioned functions are commonly used in the clinical treatment of T2DM. Although most patterns would fail to change significantly in the short term, over the long term, the patterns of a considerable proportion patients may turn into spleen-deficiency stomach-heat liver-qi-stagnation pattern, yin-deficiency effulgent-fire phlegm-heat-binding pattern, and qi-deficiency blood-stasis yin-yang-deficiency pattern.
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A model for diagnosing TCM cold and heat patterns based on random forest algorithm*
Shu Chenjie, Liang Hao, Wang Yun
2021, 44 (6):  538-543.  doi: 10.3969/j.issn.1006-2157.2021.06.008
Abstract ( 46 )   PDF (1662KB) ( 15 )  
Objective To construct a model for diagnosing cold and heat patterns from the perspective of symptoms to provide basis for standardizing cold-heat pattern identification. Methods Symptoms related to the “cold” and “heat” patterns were selected from a constructed pattern elements-symptom data table from “Study on Pattern Standardization and Pattern Identification System”. The top 15 symptoms were selected through feature screening of random forest algorithm. The dataset was split randomly into the training set and the test set with a ratio of 7∶3. After the data were resampled, random forest models for the cold and the heat patterns were constructed with the best parameters. The models were then evaluated with parameters including area under the ROC curve (AUC), sensitivity and specificity. Results The key characteristic variables of cold patterns include tight floating pulse, aversion to cold, absence of sweating, white tongue coating, pain relieved with warmth, cold pain, pale tongue, aversion to cold with fever, absence of thirst, body pain, headache, greasy coating, poor appetite, loose stool, and cold limbs. The model has an AUC of 0.912, a specificity of 0.89, and a sensitivity of 0.80. The key characteristic variables of heat patterns include yellow coating, thirst, slippery rapid pulse, fever, high fever, rapid pulse, dark urine, red tongue, wiry rapid pulse, bitter taste in the mouth, greasy coating, crimson tongue, brown urine, vexation, and headache. The model has an AUC of 0.891, a specificity of 0.85 and a sensitivity of 0.86. Conclusion Based on variable screening and random forest algorithm, models for identification of cold and heat patterns could be established with satisfactory classification effect, which could serve as an indirect means of standardizing cold and heat pattern identification.
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TCM Constitutions
Distribution of TCM constitution types of 177 patients with allergic rhinitis and its correlation with anxiety and depression*
Wang Yaqi, Luo Bin, Zhao Weibo, Chen Botian, Wang Ji
2021, 44 (6):  544-549.  doi: 10.3969/j.issn.1006-2157.2021.06.009
Abstract ( 46 )   PDF (625KB) ( 27 )  
Objective To explore the distribution of TCM constitution types of patients with allergic rhinitis (AR) and its correlation with anxiety and depression. Methods 243 AR cases who visited Guoyitang Clinic, Beijing University of Chinese Medicine, Beijing Hongyitang TCM Hospital, and the clinic of Shanghai East Hospital, Tongji University in 2020 and 200 common subjects without AR were selected. The TCM constitution types of all the subjects were identified and they were evaluated with Generalized Anxiety Disorder(GAD-7) and Patient Health Queationaire-9(PHQ-9). The distribution of the TCM constitution types of 177 AR patients who completed the valid questionnaire and their evaluation results of anxiety and depression were analyzed with Spearman correlation coefficient, and the anxiety and depression state of 180 common subjects who completed the valid questionnaire were statistically analyzed. Results The most common TCM constitution type of the 177 AR patients was the yang-deficiency constitution (22.0%), followed by special-diathesis constitution (20.3%). The number of cases with composite TCM constitution types in the 177 AR patients was 456, of which special-diathesis constitution was the most common (19.7%), followed by yang-deficiency constitution(18.2%). The most common TCM constitution type of those with anxiety and depression among the 177 AR patients was yang-deficiency constitution. Among the 177 AR cases, those with mild to severe anxiety accounted for 28.2%, those with mild to severe depression accounted for 48.6%, and those with mild to severe anxiety and depression accounted for 24.3%. Among the 180 subjects without AR, 21.1% suffered from mild to severe anxiety, 30.0% mild to severe depression, and 14.4% mild to severe anxiety and depression. All biased TCM constitutions were related positively with anxiety and depression state. The qi-stagnation constitution (r=0.642, P=0.001), phlegm-wetness constitution (r=0.303, P=0.001), and blood-stasis constitution (r=0.281, P=0.001) were positively correlated with anxiety. The qi-stagnation constitution (r=0.588, P=0.001), qi-deficiency constitution (r=0.506, P=0.001), and blood-stasis constitution (r=0.447, P=0.001) were positively correlated with depression. The gentleness constitution was negatively correlated with anxiety (r=-0.448, P=0.001) and depression (r=-0.640, P=0.001). Conclusion The yang-deficiency constition and the special-diathesis constitution are the most common TCM constitution types of AR patients. Patients with allergic rhinitis are more likely to develop anxiety and depression than people without AR. The most common TCM constitution type of AR patients with anxiety and depression is the yang-deficiency type. Qi-stagnation constitution, phlegm-wetness constitution and blood-stasis constitution are more positively related to anxiety, and qi-stagnation constitution, qi-deficiency constitution and blood-stasis constitution are more postitive related to depression. However, gentleness constitution was negatively related to anxiety and depression.
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Clinical Studies
Effects of acupoint application of Fengtong Plaster on meridian state in patients with ankylosing spondylitis with kidney deficiency and governor vessel cold*
Jin Shuchun, Mao Jianchun, Sun Ding, Zhou Jun, Wang Xiao, Zhu Zhujing, Deng Yuxin, Yang Yeying
2021, 44 (6):  550-555.  doi: 10.3969/j.issn.1006-2157.2021.06.010
Abstract ( 39 )   PDF (810KB) ( 15 )  
Objective To assess with telediagnosis system(TDS) the meridian states of patients with ankylosing spondylitis (AS) with kidney deficiency and governor vessel cold treated with Fengtong (Wind-pain-relieving) Plaster at acupoints to explore the possible Objective TCM evaluation criteria for AS. Methods Randomized controlled trial was used to divide cases of AS with patterns of kidney deficiency and governor vessel cold into the treatment group and the control group. Both groups were treated with the conventional Western medicine Meloxicam and the treatment group was given acupoint application of Fengtong Plaster additionally for 4 weeks. TCM pattern scores and the proportion of the energy in the kidney meridian and bladder meridian in the energy in all the meridians before and after 4 weeks of treatment were observed and compared. Results After 4 weeks of treatment, the total effective rate of the treatment group reached 94.59% while that of the control group was 32.43% with statistically significant difference (P<0.05). In terms of specific symptoms such as stiffness of the back and waist, coldness of the back and waist, soreness and weakness of the lower back and knees, aversion to cold and desire for warmth, the treatment group improved more than the control group (P<0.05). There was no significant difference in the proportion of the energy in the kidney meridian within each group before treatment and after treatment and between groups after treatment (P>0.05). The proportion of the energy in the bladder meridian in the treatment group increased significantly after treatment compared with before treatment (P<0.01) while there was no significant increase in the control group before and after treatment (P>0.05). Compared with the control group, the proportion of the energy in the bladder meridian increased more significantly in the treatment group after treatment (P<0.05). Conclusion Fengtong Plaster acupoint application can improve the TCM efficacy in patients with AS with kidney deficiency and governor vessel cold and improve the proportion of the energy in the bladder meridian. TDS Meridian Detector may provide the basis for Objective evaluation of TCM efficacy for ankylosing spondylitis.
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Acupuncture & Moxibustion
Observation of the clinical efficacy of routine acupuncture combined with “yi zhen ting” acupuncture in the treatment of long-term deafness*
Chen Yinghua, Zhao Jinghua, Qin Ruiqi, Su Xiaoqing, Li Junfeng, Wang Haoyu, Sun Xinghua
2021, 44 (6):  556-561.  doi: 10.3969/j.issn.1006-2157.2021.06.011
Abstract ( 39 )   PDF (801KB) ( 13 )  
Objective To observe the clinical effect of conventional acupuncture combined with acupuncture at “yi zhen ting” acupoint (the midpoint of the line between SI 19 and GB 2) in the treatment of long-term deafness. Methods A total of 60 patients with long-term deafness treated in the First Affiliated Hospital, Heilongjiang University of Chinese Medicine from December 2019 to October 2020 were selected and randomly divided into the observation group and control group using a random number table, with 30 patients in each group. While the control group was treated with conventional acupuncture therapy for the disease, the observation group was treated with conventional acupuncture combined with “yi zhen ting” acupuncture. The treatment course for both groups was 4 weeks. The changes in pure-tone threshold audiometry, tinnitus severity of patients with tinnitus, Hamilton Anxiety Rating Scale (HAMA) score of patients with anxiety, and WHOQOL-BREF score of patients were compared between the 2 groups before and after treatment. Results In the observation group, the total effective rate was 86.67%, while that of the control group was 76.67%. The clinical efficacy of the observation group was better than that of the control group (P<0.05). Compared with before treatment, the pure-tone threshold of patients, the HAMA score of patients with anxiety, and the WHOQOL-BREF score of patients in both the control group and the observation group decreased (P<0.01). After treatment, compared with the control group, the pure-tone threshold of patients and the HAMA score of patients with anxiety were lower and the WHOQOL-BREF score of patients was higher in the observation group (P<0.05). In the observation group, the total effective rate of tinnitus was 94.12% while that in the control group was 83.33%. The clinical efficacy of tinnitus in the observation group was better than that in the control group (P<0.05). Conclusion Routine acupuncture combined with “yi zhen ting” acupuncture is effective in the treatment of long-term deafness in that it improves the hearing, the accompanying tinnitus and anxiety, and the quality of life of patients. Therefore, it could be applied widely in clinic.
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Clinical observation of the cognitive function and intestinal microecology of patients with vascular dementia treated with Tiaoshen Yizhi acupuncture combined with Dingzhi Yicong Fang*
Yang Yuanqing, Li Si, Ji Xuequn, Zhang Ping, Yang Xiujuan, Zhang Zhilong
2021, 44 (6):  562-568.  doi: 10.3969/j.issn.1006-2157.2021.06.012
Abstract ( 27 )   PDF (843KB) ( 13 )  
Objective To explore the effect of Tiaoshen Yizhi (Mind-regulating and Intelligence-improving, TSYZ) acupuncture combined with Dingzhi Yicong Fang (Mind-calming and Intelligence-improving Formula, DZYCF) on the mental state, cognitive function and intestinal microecology of patients with vascular dementia (VD). Methods 64 patients with vascular dementia who met the inclusion criteria were randomly divided into the observation group and the control group, 32 cases in each group. The observation group was treated with TSYZ acupuncture combined with DZYCF, and the control group was treated with donepezil hydrochloride for 60 days. The changes in MMSE, BBS, BI, cognitive scale of Alzheimer Disease Rating Scale (ADAS-Cog), TCM pattern scores and the numbers specific intestinal floras were assessed and analyzed before and after treatment. Results The total effective rates of the two groups were 84.38% and 62.50% with statistically significant difference (P<0.05). Compared with before treatment, the MMSE and BI scores and the numbers of floras of bifidobacterium, lactobacillus, peptococcus, saccharomycetes, and bacteroides increased, the numbers of floras of enterococcus, bacillus coli, and clostridium parvum and the BBS, ADAS-Cog and TCM pattern scores of both groups decreased after treatment (P<0.05, P<0.01). After treatment, compared with the control group, the MMSE and BI scores and the numbers of floras of bifidobacterium, lactobacillus, peptococcus, saccharomycetes, and bacteroides increased, the numbers of floras of enterococcus, bacillus coli, and clostridium parvum and the BBS, ADAS-Cog and TCM pattern scores of the observation group decreased (P<0.05, P<0.01). Conclusion TSYZ acupuncture combined with DZYCF can improve the mental state, cognitive function, social capability, daily life function, and TCM pattern of VD patients, and can effectively restore the balance of intestinal floras and maintain the stability of intestinal microecology. With better curative effect than conventional treatment using Western medicine, it could be a new way to treat VD clinically.
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Clinical observation of the improving effects of acupuncture at sphenopa-latine ganglia on different symptoms of 222 patients with allergic rhinitis*
Zhang Peng, Shang Xiaojuan, Tan Yi, Yang Jing, Wang Kuiji, Xu Shiwen, Wang Xiang, Sun Sanfeng, Yu Kun, Zhao Xinyu, Shu Ning, Yang Wei, Chen Luquan
2021, 44 (6):  569-576.  doi: 10.3969/j.issn.1006-2157.2021.06.013
Abstract ( 41 )   PDF (938KB) ( 15 )  
Objective To observe the differences in the improvement degree, speed and persistence of different symptoms in the treatment of allergic rhinitis (AR) with acupuncture at sphenopalatine ganglion in a multicenter, noncontrolled study, and analyze the effects of the acupuncture therapy on AR symptoms. Methods The clinical data were collected of 222 cases of AR patients treated with acupuncture at sphenopalatine ganglion from April 2017 to June 2018 twice a week for four weeks in seven centers in Beijing. At 5 time points, i.e. before treatment(Week 0), the 2nd, 3rd, and 4th week during treatment (Week 2, Week 3, and Week 4) and during the follow-up (Week 8), the numbers of cases with different degrees of the four main symptoms including nasal congestion, runny nose, itching nose and sneezing selected from Total Nasal Symptom Score (TNSS) were recorded and the numbers of cases with and without the five accompanying symptoms including nasal discharge flowing through the pharynx, tears, itching nose or eyes, nasal or oral maxillary pain and headache selected from Total Nonnasal Symptom Score (TNNSS) were also recorded. Non-parametric tests of score data were performed on the distribution of cases at different time points to compare the changes in the distribution of the main symptoms and accompanying symptoms. The effects of acupuncture at sphenopalatine ganglion were compared on the basis of the numbers of patients whose symptoms were relieved, eliminated, unchanged and aggravated at the end of the follow-up compared with those before treatment. Results Before and after treatment, there were statistically significant differences in the overall distribution of symptom scores of nasal congestion, runny nose, itching nose and sneezing (P<0.05). In addition, the symptoms were milder at the later time point between every two adjacent time points (P<0.01). There were also statistically significant differences in the overall distribution of symptom scores of nasal discharge flowing through the pharynx, tears, itching nose or eyes, nasal or oral maxillary pain and headache (P<0.05), among which the first four symptoms were milder at the later time point between every two adjacent time points (P<0.01). Conclusion Acupuncture at sphenopalatine ganglion can relieve the main and associated symptoms of AR with definite efficacy. AR patients with the main clinical manifestations of sneezing, nasal congestion, runny nose and nasal itching are more likely to obtain satisfactory results thanks to acupuncture at sphenopalatine ganglion.
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