ISSN 1006-2157　CN 11-3574/R

### Quality characteristics and correlation analysis of medicinal preparations from Xiongshao Fang*

CHI Lei1,SUN Ya-shu1,YANG Shu-juan1,PAN Ting1,WEN Jing2,HUANG Ya-ting1,LI Huan-juan1,ZHANG Lu1,PENG Ping1,JIANG Yan-yan1,3,SHI Ren-bing1,3*

1. 1 Key Unit of Exploring Effective Substances of Classical and Famous Formulas of State Administration of Traditional Chinese Medicine,School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100102;
2 School of Traditional Chinese Medicine,Capital University of Medical Sciences;
3 Quality Control Technology and Engineering Center of Chinese Medicine,Beijing Municipal Commission of Education
• Received:2014-10-25 Online:2015-03-28 Published:2015-03-28

Abstract: Objective To determin the key factors affecting the quality of Xiongshao Fang and the best preparation forms of medicinal in Xiongshao Fang, laying the groundwork of anti-migraine drug from Xiongshao Fang. Methods Based on drug system, the content of effective index components of preparation of Xiongshao Fang was detected by using HPLC-PDA. The quality of medicinal preparation from Xiongshao Fang were characterized based on the content, relative quantity, relative ratio of content, yield rate and anti-migraine effect, and the characterized results were given correlation analysis. Results The effect of anti-migraine of three medicinal preparations from Xiongshao Fang was listed in the following descending order of enrichment, ethanol extract, and water extract. The enrichment was the best preparation form of medicinal in Xiongshao Fang with the highest content of effective index components, lowest extract rate, lowest dosage and best effect of anti-migraine, resulted from the medicine-efficacy correlation analysis. Conclusion The method of the determination of effective index components from Xiongshao Fang is easy to handle, accurate and highly reproducible. Based on the basic composition and extraction rate of medicinal system, the key factor of increasing medicinal efficacy is promotion of the content and optimization of proportion of the relative effective components.

CLC Number:

• R284.1