主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (5): 351-355.doi: 10.3969/j.issn.1006-2157.2015.05.013

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ACTH and GC levels in patients with hepatitis cirrhosis at two stages and their correlation with TCM pattern elements*

ZHAO Feng-run 1, ZHAO Li-hong 1, WANG Tian-fang1#, XUE Xiao-lin 1, WU Xiu-yan 1, LI Yong-gang 2, LI Ning 1, WANG Si-ying 1, YANG Hui-yin 2, JIANG Yu-yong 3, LIU YAN-ling 4, CHEN Sheng-duo 5, ZHANG Qiu-yun 6, LI Xiu-hui 7, MAO De-wen 8, ZHANG Chang 9, LIU Wen 10   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029;
    2 People’s Liberation Army 302 hospital;
    3 Beijing Ditan Hospital, Capital Medical University;
    4 Xiyuan Hospital, China Academy of Chinese Medical Sciences;
    5 The Hubei Provincial Traditional Chinese Medical Hospital;
    6 Capital Medical University;
    7 Beijing Youan Hospital, Capital Medical University;
    8 The First Affiliated Hospital, Guangxi University of Traditional Chinese Medicine;
    9 Dongfang Hospital, Beijing University of Chinese Medicine;
    10 Beijing Chinese Medicine Hospital, Capital Medical University
  • Received:2015-01-12 Online:2015-05-15 Published:2015-05-15

Abstract: Objective To compare the levels of serum adrencortical hormone (Adrenocorticotropic hormone, ACTH), and glucocorticoid (Glucocorticoid, GC) between patients of hepatitis cirrhosis at compensated and decompensated stages, and to evaluate their correlation with common TCM pattern elements. Methods Using a unified “hepatitis cirrhosis clinical information collection list”, which is formulated by this team, we conducted a national multi-center cross-sectional epidemiological survey, to collect the general condition of patients, their symptoms and other information. We also collected their blood samples for standardized laboratory tests. Previously published consensus and guidelines on diagnosis and treatment of hepatic cirrhosis were reviewed. With reference to literature review of clinical investigation, and finally we came up with a“common pattern element identification standard for hepatitis cirrhosis” after two rounds of expert consensus verification process. According to this standard, we can analyze the pattern elements and compare the differences between serum ACTH and GC levels during compensated and decompensated stages, as well as those between the pattern elements of blood stasis, yin deficiency, damp heat, qi stagnation, Qi deficiency, Yang deficiency, and water retention. ResultsCompared with patients at compensated stage, ACTH and GC levels in patients at decompensated stage were elevated, with significant difference in GC levels (P<0.05). In patients at decompensated stage, levels of ACTH in patients with Yang deficiency group was significantly lower than those in groups without it (P<0.05); In patients with blood stasis at decompensated stage, the level of ACTH was significantly higher than those in groups without it (P<0.05), but GC was higher than that of the other groups (P<0.05) in terms of pattern elements (except water retention). Conclusion ACTH and GC levels in patients with hepatitis cirrhosis could reflect the severity of disease, and may suggest a certain correlation with TCM pattern elements of class of common diseases.

Key words: liver cirrhosis, compensated and decompensated stages, pattern elements, ACTH, GC

CLC Number: 

  • R259.75