主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (7): 444-446.doi: 10.3969/j.issn.1006-2157.2015.07.003

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Hemostatic effect and mechanism of wind-dispelling Chinese medicinal herbs

HU Hong-lin, YANG Zhen, LU Sai, GAO Lin#   

  1. School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029
  • Received:2015-01-19 Online:2015-07-30 Published:2015-07-30

Abstract: Wind-dispelling Chinese medicinal herbs were widely used in syndrom of bleeding due to the effect of hemostasis. Based on the experiences of clinical practice, the ancient TCM physicians summarized that bleeding was caused by“wind pathogen damaged blood”, that is to say, wind pathogen, tending to move and change, blowed the blood to flow outside the channels. While modern medical literature showed that inducible nitric oxide synthase (iNOS) was the key factor closely related to syndrom of bleeding, the anticoagulant effect of iNOS worked mostly through producing a large amount of nitric oxide(NO) and promoting expression of cyclooxygenase- 2(COX-2). Wind-dispelling medicine could down-regulate gene expression of iNOS at different steps to inhibite the production of NO and expression of COX-2, so as to promote platelet adhesion and aggregation and vasoconstriction. The hemostatic mechanism of wind-dispelling medicine is potentially related to the anti-inflammatory effects reducing inflammatory cytokines.

Key words: Key words: wind-dispelling Chinese medicinal herbs, hemostasis, iNOS, COX-2

CLC Number: 

  • R287