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    On naming COVID-19 in traditional Chinese medicine *
    Liu Tiegang, Bai Chen, Liu Shaoyang, Long Chaojun, Hu Li, Zhao Yansong, Yu He, Gu Xiaohong
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (10): 797-803.   DOI: 10.3969/j.issn.1006-2157.2020.10.001
    Abstract443)      PDF(pc) (1274KB)(273)       Save
    Through review of national and regional Diagnosis and Treatment Plan of Corona Virus Disease 2019 (COVID-19) and related literature, this article analyzed the characteristics of COVID-19, and probed into its TCM nomenclature, combining the naming rules for pestilence in traditional Chinese medicine (TCM). The terms used for COVID-19 in TCM currently include pestilence, cold pestilence, cold-damp pestilence, cold-damp lung pestilence, damp pestilence, dampness-toxin pestilence, warm pestilence, damp-heat pestilence, lung pestilence, wind pestilence, winter pestilence, wind-warm and damp pestilence, wood pestilence, etc. COVID-19 can be generally referred to as “pestilence”in TCM; according to the nature of the symptoms and the characteristics of the pathogenesis, it can be named as “dampness-toxin pestilence” since symptoms of damp nature have maintained throughout the disease course with the pathogenesis of stasis and toxin obstruction; the name of “lung pestilence” according to disease location fails to reflect the lesion site of the disease; the name of “winter pestilence”, “wind pestilence” and “wind-warm and dampness pestilence” according to the time of onset, though in accordance with the definition of warm diseases, does not conform to the characteristics and pathological rules of the disease; according to the five elements motion and six climatic changes, it can be named as “wood pestilence”. At present, it is not suitable to name the disease only according to clinical characteristics, but with increased understanding of this disease, the nomenclature may be further improved.
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    Clinical observation of 40 cases of Agkistrodon acutus bite treated with Lianhua Jiedu Tang *
    Chen Jun, Dong Degang, Yan Zhangren, Wang Wanchun, Yi Jun, Mao Wenli, Li Yanfang, Wang Jiangang, Zhang Naixin, Liu Liang, Wang Xi
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (12): 1053-1057.   DOI: 10.3969/j.issn.1006-2157.2020.12.013
    Abstract424)      PDF(pc) (657KB)(35)       Save
    Objective To observe the clinical effect of Lianhua Jiedu Tang (Bearded Scutellaria Toxin-removing Decoction, LHJDT) on Agkistrodon acutus bite. Methods 80 patients bitten by Agkistrodon acutus were randomly divided into control group and treatment group with 40 patients in each group. While the control group was given conventional Western medical treatment, patients in the treatment group took LHJDT orally in addition to the conventional treatment. During one-week treatment, the average recovery time, the time swelling, pain and ecchymosis took to subside, and the total scores of local symptoms and systemic signs of the two groups before and after treatment were measured and recorded; furthermore, the total effective rates of the two groups were compared. Results The total effective rates were 87.17% and 65.78% in the treatment and control groups respectively. There were significant differences between the two groups of patients in the average recovery time, the time swelling, pain and ecchymosis took to subside, and the total scores of local symptoms and systemic signs on Day 3 and Day 7 during the treatment course. The curative effect of the treatment group was better than that of the control group ( P<0.05). Conclusion LHJDT can inhibit the activity of snake venom of Agkistrodon acutus with definite therapeutic effect, and further clinical application is needed.
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    Textual research on the dosage of Kai Xin San in Qian Jin Yao Fang *
    Zhang Lin, Zeng Feng
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 641-644.   DOI: 10.3969/j.issn.1006-2157.2020.08.005
    Abstract343)      PDF(pc) (1126KB)(223)       Save
    With Kai Xin San (Joy Powder) in Directory of Famous Formula in Ancient Times as the study object, this paper explored the difference of the dosage in two different versions of Qian Jin Yao Fang (Important Formulas Worth a Thousand Gold Pieces): Song version and Xindiao version. In the textual research, we have taken the characteristics of the above two editions into consideration, and have compared the relevant record of other formulas in Song version. Also, we have referred to the relevant record in the contemporary book Yi Xin Fang as proof. It’s concluded that the original dosage of Kai Xin San (Joy Powder) should be “Four Fen (one Liang) of Yuanzhi (thin-leaf milkwort root, Radix Polygalae) and Renshen (ginseng, Radix et Rhizoma Ginseng) respectively, two Liang of Fuling (poria, Poria), and one Liang of Changpu (grassleaf sweetflag rhizome, Rhizoma Acori Tatarinowii)”. According to the research result on the medicine tool “Fang Qi Bi” in Research on the Original Dosage in Classical Formula, the dosage is converted to modern measuring unit: Yuanzhi (thin-leaf milkwort root, Radix Polygalae) 13.8 g, Renshen (ginseng, Radix et Rhizoma Ginseng) 13.8 g, Fuling (poria, Poria) 27.6 g; and Changpu (grassleaf sweetflag rhizome, Rhizoma Acori Tatarinowii) 13.8 g, and the daily administration should be Yuanzhi (thin-leaf milkwort root, Radix Polygalae) 3 g, Renshen (ginseng, Radix et Rhizoma Ginseng) 3 g, Fuling (poria, Poria) 6 g, and Changpu (grassleaf sweetflag rhizome, Rhizoma Acori Tatarinowii) 3 g.
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    Conception of life science from the perspective of Chinese medicine
    Xu Anlong, Shi Yuanyuan, Lu Tao, Jiang Miao, Li Feng, Liu Jianping, Li Hongmei
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 623-629.   DOI: 10.3969/j.issn.1006-2157.2020.08.002
    Abstract343)      PDF(pc) (1214KB)(186)       Save
    The rise of modern life science has triggered a revolution in thinking and understanding of the essence of life academically. With the rapid development of modern science and technology, the modern biomedicine, represented by precision medicine and system biology, is constantly getting close to the holistic view of life cognition and the thought of the unity of man and nature in Chinese medicine. Although they belong to different academic thinking systems, with the assimilation and high quality of the global human demand for life care, the integration of Chinese medicine and Western medicine is the inevitable trend of future development. In order to promote this integration to be more orderly and quickly formed, this article attempts to propose a new disciplinary concept: Life Science From the Perspective of Chinese Medicine. This concept covers four major elements, namely, matter, energy, information and space-time. In order to promote the development of new medicine based on life science from the perspective of Chinese medicine, the combination point of life view of Chinese medicine and modern science is explored. The initial specific research directions are: the systematic material basis of Chinese medicine life concept, the energy, information, temporal and spatial changes under laws of Chinese medicine life concept, the intelligent training of Chinese medicine big data, and the development of medical engineering equipment for Chinese medicine life concept so that Chinese medicine can serve human health more effectively in the modern environment, realize the integration of Chinese and Western medicine under the framework of integration, and provide the basic support of life science for the establishment of new medicine.
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    Prevention and treatment strategy of COVID-19 from the perspective of TCM membrane system *
    Yang Guannan, Jiang Xin, Gu Xiaohong
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 630-635.   DOI: 10.3969/j.issn.1006-2157.2020.08.003
    Abstract293)      PDF(pc) (1192KB)(240)       Save
    For COVID-19, there is currently limited effective therapeutic approach or antiviral drugs at present. According to traditional Chinese medicine (TCM), COVID-19 belongs to the category of “damp plague”, and it can be diagnosed and treated with distinctive pattern differentiation methods. However, its pathogenesis and transmission still needs further exploration. The TCM membrane system theory is a systematical summary of the understanding of “membrane” based on TCM ancient literature and modern medicine. The membrane system is distributed over all body cavities, connects the three jiao and covers all of the membrane-layered structures composed of connective tissue and epithelial tissue in the whole body. This system is regarded as the physiological pathway of qi, water and fire, as well as the pathological pathway of the pathogenic factors. It is believed that the damp-warm-heat pathogenic factors invade the membrane from the external mucosal membrane system of all orifices in the human body, and distribute inside of the body along the inner and outer membrane systems. The abnormality of membrane system is the core factor of the occurrence and transmission of the disease. On the base of such pathogenesis, it is proposed that the principle of prevention and treatment of COVID-19 should be defending the toxic pathogenic factors and dredging the membrane system so as to promote the elimination and excretion of pathogenic factors.
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    Pandemic risk factor analysis of COVID-19 and inspirations from its prevention and control
    Wang Yongyan, Wang Zhong, Bai Weiguo, Zhi Yingjie, Wang Yanping
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 621-622.   DOI: 10.3969/j.issn.1006-2157.2020.08.001
    Abstract283)      PDF(pc) (1316KB)(816)       Save
    In order to promote effective prevention and control of the pestilence by traditional Chinese medicine (TCM), it’s of great significance to explore the main ways of the pestilence epidemic. The most weighted epidemic factor is the environmental degradation. Thus, the application of the Yunqi Theory emphasizing “harmony between man and nature” into the prevention and treatment of the pestilence in clinic would be the best way to gain the common consent of the effect and the decrease of the mortality, which might be a good opportunity to show TCM contribution to the health of the human. Based on the standardization of the operation procedures, it’s further suggested that extraction of key elements in patterns of the disease should be viewed as a breakthrough, combined with various technologies from the network, block data and big data of biological blockchain, thus ushering in the third stage of Chinese epidemiology.
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    Similarities and differences in thinking on tonifying the kidney between Zhu Zhenheng and Zhang Jiebin *
    Xi Chongcheng, Tian Dong, Liu Jintao, Zhang Ning, Liu Zhenzhu, Wang Weiguang, Chen Zijie, Zhai Shuangqing
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 636-640.   DOI: 10.3969/j.issn.1006-2157.2020.08.004
    Abstract280)      PDF(pc) (1184KB)(191)       Save
    As one of the four great scholars in Jin and Yuan Dynasties, theory of Zhu Zhenheng(Zhu Danxi) has great influence on later generations. Zhang Jiebin studied Zhu Danxi’s theory in his early years. While criticizing and inheriting Zhu Zhenheng’s thought of nourishing yin, he became one of the representatives of the warm-nourishing school. Zhu Zhenheng and Zhang Jiebin both attach importance to supplementing kidney essence so as to tonify the kidney; in the selection of medicinals, medicinals from plants and animals are combined; besides, they both take pills as the main drug form. However, their thoughts differ in the following aspects. In warming and nourishing kidney yang, Zhu Zhenheng prefers to use moderate medicinals to generate qi without causing fire, while Zhang Jiebin prefers to use medicinals extremely pungent and heat in nature for quick effect. In nourishing kidney yin, Zhu Zhenheng advocates that yin-nourishing medicinals should be combined with bitter cold ones, then ministerial fire can be cleared; while Zhang Jiebin prefers to combine yin-nourishing, qi-supplementing and yang-warming medicinals to seek yin within yang. In Conclusion, Zhu Zhenheng’s and Zhang Jiebin’s thoughts on tonifying the kidney play a guiding role in the clinical treatment of various diseases with kidney deficiency pattern.
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    Discussion of “macules out of yangming and papules out of taiyin” from the perspective of qi transformation *
    Wu Zhongde, Zhu Xing
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (3): 209-214.   DOI: 10.3969/j.issn.1006-2157.2021.03.003
    Abstract274)      PDF(pc) (852KB)(89)       Save
    “Macules out of yangming and papules out of taiyin” is a summary of the view that “macules are caused by heat toxin in yangming and papules are caused by wind heat in taiyin” proposed by Lu Zixian, a physician in the Qing Dynasty. However, the understanding of yangming and taiyin in later generations was mostly limited to the idea that “the lung governs the skin and body hair, and the stomach governs the muscles”, but neglected the meaning of yangming and taiyin in terms of the six meridians. This paper analyzes the occurrence and treatment of macules and papules from the perspective of qi transformation. Based on analysis and discussion of related previous medical cases, it is believed that both the invasion of yangming and taiyin by pathogens and the deficiency of the two meridians can lead to qi transformation disorder, forming macules and papules. Meanwhile, due to the exterior-interior relationship between yangming and taiyin, macules and papules can be transformed into each other to a certain extent. Therefore, it is necessary to differentiate whether the disease is of cold or heat, deficiency or excess pattern on the whole in clinical practice, so as to seek a better treatment plan for macules and papules.
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    Discussion on the TCM concept of pathogenic“wind” *
    He Juan
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (11): 885-891.   DOI: 10.3969/j.issn.1006-2157.2020.11.001
    Abstract266)      PDF(pc) (1239KB)(153)       Save
    In the TCM etiology theory,wind serves as the first of the six pathogenic factors.Based on the original sentences related to “wind” in Huangdi Neijing (The Yellow Emperor’s Inner Classic),later generations have endowed the “wind”,a climatic phenomenon with many attributes and characteristics.However,the concept of “wind” in Huangdi Neijing (The Yellow Emperor’s Inner Classic) is actually a mixture of multi-layer concepts,which not only could be interpreted in both broad and narrow senses,but also could be classified into being related to either qi transformation or climate.Frequently,“wind” is a general concept for external pathogenic factors,like “wind is the source and leading cause for all diseases”,and “wind is a yang pathogenic factor,thus damaging the upper part of the body first”.While in “if wind dominates,it’s manifested as shaking or tremoring of the body,or constant changing of the condition”,“wind” is a pathological concept indicating qi transformation in Yunqi Theory.In later generations,apart from the connotation of “wind” as one of the six pathogenic factors,the other layers of the concept have been mixed to enlarge the concept of pathogenic wind.It has led to the mystification of the concept,confusion of theory and disconnection from clinical practice.
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    On “deficient pathogen” in Huangdi’s Internal Classic *
    He Juan
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (1): 9-13.   DOI: 10.3969/j.issn.1006-2157.2021.01.002
    Abstract264)      PDF(pc) (879KB)(109)       Save
    The pathogen,also known as “deficient pathogen”,falls into the core category of etiology in Huangdi Neijing (Huangdi’s Internal Classic), where there are specific statements of its properties,occurrence,and the timing of disease onset.The pathogen refers to non-seasonal pathogenic qi of natural climate.The concept of deficient pathogen originates from the doctrine of five evolutive phases and six climatic factors.The deficient pathogen,also termed as the alternating qi,refers to the climate deriving from other seasons triggered by qi deficiency due to failure of transportation in the middle jiao. An in-depth analysis of the pathogen and the deficient pathogen is of great significance for interpreting the etiological theory of Huangdi Neijing and giving full play to its role in prevention and treatment of diseases.
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    Mechanism of Majie Decoction against allergic rhinitis based on network pharmacology and preliminary verification *
    Wu Jinyang, Zhang Boran, Zhang Yuteng, Zhang Hongchun
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 675-679.   DOI: 10.3969/j.issn.1006-2157.2020.08.010
    Abstract259)      PDF(pc) (2179KB)(179)       Save
    Objective To study the mechanism of Majie Decoction (Ephedra and White Mustard Seed Decoction) against allergic rhinitis based on network pharmacology and preliminarily verify it through in vivo experiments in mice. Methods Effective constituents of Majie Decoction (Ephedra and White Mustard Seed Decoction) were selected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP database) based on threshold of oral availability (OB) and drug-likeness (DL). Then corresponding targets of the selected constituents were obtained to form an effective constituents-targets network Targets relevant to allergic rhinitis were achieved based on Digsee database. The intersection dataset of these datasets was analyzed. Then the protein-protein reaction and its effect on the KEGG/Reactome pathway were analyzed based on String database. IL-4 signal pathway were verified by mouse model. Results 53 unduplicated effective constituents, including neobaicalein, panicolin, and 34 important targets against allergic rhinitis, including ESR1, AR, PPARG, PTGS2, DPP4, were obtained. The protein interaction network and enrichment analyses showed that targets of Majie Decoction (Ephedra and White Mustard Seed Decoction) are enriched in various inflammatory factor-related pathways. Animal experiments showed that Majie Decoction (Ephedra and White Mustard Seed Decoction) significantly reduced the levels of serum IgE, histamine and IL-4 in mice with allergic rhinitis. Conclusion The main mechanism of Majie Decoction (Ephedra and White Mustard Seed Decoction) may be relevant to regulation of multiple inflammatory factor-related pathways, especially IL-4 and IL-13.
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    TCM constitution types of gestational diabetes mellitus and their correlation to complications during pregnancy and childbirth *
    Wang Jingshang, Wu Ying, Liu Xiaowei, Li Yuan, Guo Cuimei, Wu Ying, Yin Xiaodan, Li Xianrui, He Junqin
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 696-701.   DOI: 10.3969/j.issn.1006-2157.2020.08.013
    Abstract240)      PDF(pc) (1149KB)(81)       Save
    Objective To observe the TCM constitution types of gestational diabetes mellitus (GDM), and their correlation to complications during pregnancy and childbirth. Methods 144 cases who took routine pregnancy check-up in Beijing Obstetrics and Gynecology Hospital, Capital Medical University, were enrolled, including GDM group and control group (no pregnancy complications) ( n=72). The levels of fasting blood glucose (FBG), glycosylated hemoglobin (HBA1c) and glycosylated serum protein (GSP) were measured on enrollment. The TCM constitution identification was done on enrollment and before delivery. The occurrence of complications during pregnancy and childbirth were recorded. Results The levels of FBG, HBA1c and GSP in the GDM group were significantly higher than those in the control group ( P<0.01). The proportion of biased constitutions in the GDM group was significantly higher than that in the control group ( P<0.01). On enrollment, the most common TCM constitution types in the GDM group were Yin Deficiency Constitution and Phlegm-Dampness constitution, accounting for 27.78% and 20.83% respectively. Before delivery, the proportion of Yin Deficiency Constitution and Phlegm-Dampness Constitution in the GDM group were 26.4% and 18.1% respectively. The incidence of complications during pregnancy and delivery in the GDM group was significantly higher than that in control group ( P<0.05). Yin Deficiency, Qi Deficiency, Dampness-Heat and Phlegm-Dampness were the four constitution types with the highest incidence of complications during pregnancy and childbirth in the GDM group, which were significantly higher than those in the control group. In the GDM group, the complications rates ofthe Yin Deficiency Constitution were all higher than that of Balanced Constitution( P<0.05). Conclusion Patients with GDM seem to be more likely to have biased constitution types, especially Yin Deficiency and Phlegm-Dampness Constitutions. Meanwhile the incidence of complications during pregnancy and perinatal period in GDM patients with Yin dificiency Constitution seems to be higher than those with a Balanced Constitution. The study provides clinical reference for early prevention and treatment.
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    New insights into TCM pattern differentiation and treatment of sound abnormality after thyroid surgery *
    Li Lijing, Peng Jing, Cao Lishuang, Xia Zhongyuan
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 702-705.   DOI: 10.3969/j.issn.1006-2157.2020.08.014
    Abstract238)      PDF(pc) (1176KB)(197)       Save
    Abnormal sound is a common complication after thyroid surgery. At present, there is no consensus on the TCM pattern differentiation or treatment methods. In this paper, it is proposed that such a disorder is caused by recurrent laryngeal nerve injury, different from “throat dysphonia” in traditional understanding. The main etiology and pathogenesis in TCM are interpreted as channel damage in the neck resulting in stasis blocking the throat and malnourishment of the vocal tract. According to the characteristics of its clinical manifestations, it can be divided into patterns of wind-heat-phlegm accumulation, qi-yin deficiency, qi stagnation, and stasis blocking the throat. On the basis of pattern differentiation, prescriptions and medicinals should be selected according to the characteristics of the specific condition, aiming at dissolving stagnation and stasis, activating blood and unblocking channels. The specialized medicinals to promote sound generation can be divided into diffusing and lung-astringing ones, and used according to the duration of the illness.
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    Protective effect and mechanism of chebulagic acid on H9C2 cells injury induced by aconitine *
    Han Shu, Liu Shuai, Zhang Qiao, Zhi Meiru, Liu Kaiyang, Tang Ya’nan, Han Xitao, Liu Ziqin, Li Fei, Du Hong
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 645-652.   DOI: 10.3969/j.issn.1006-2157.2020.08.006
    Abstract217)      PDF(pc) (4056KB)(65)       Save
    Objective To investigate the toxicity of aconitine to H9C2 cells by HCA, and to further explore the effect of chebulagic acid, the active component of He Zi (medicine terminalia fruit, Fructus Chebulae), on the cardiotoxicity induced by aconitine, and to explore its mechanism in reducing the toxicity of He Zi (medicine terminalia fruit, Fructus Chebulae). Methods Different concentrations of aconitine, chebulagic acid and aconitine + chebulagic acid were used to act on H9C2 cells respectively. Hoechst 33258 and other fluorescent probes were used to dye the cells. HCA technology was used to detect and analyze the effects of drugs of different concentrations on the number of H9C2 cells, the area of nucleus, the DNA content of nucleus, the fluorescence intensity of Ca 2+ and the influence on function of mitochondria. Results 10,20 μmol/L aconitine caused Ca 2 + overload in cardiomyocytes; 20 μmol/L aconitine caused mitochondrial dysfunction of cardiomyocytes in varying degrees after acting on cardiomyocytes for 24 hours; 5,10,20 μmol/L chebulagic acid had no obvious toxicity when acting on H9C2 cells alone; 10,20 μmol/L of chebulagic acid combined with 20 μmol/L aconitine restored the mitochondrial function and significantly reduced the fluorescence intensity of Ca 2+, compared with using aconitine alone. Compared with the control group, there was no significant difference between the two groups. Conclusions Aconitine causes calcium overload and mitochondrial dysfunction in cardiomyocytes, which may be the main cause of cardiotoxicity induced by aconitine. Chebulagic acid in He Zi (medicine terminalia fruit, Fructus Chebulae) seems to inhibit the Ca 2 + overload induced by aconitine, improve the mitochondrial function, and detoxify aconitine.
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    Effect of Dahuang (rhubarb) Granule on intestinal microecological changes in rats with chronic renal failure *
    Luo Xuewen, Zeng Yuqun, Wang Shiqi, Zou Chuan, Pi Chiheng
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 668-674.   DOI: 10.3969/j.issn.1006-2157.2020.08.009
    Abstract211)      PDF(pc) (1546KB)(69)       Save
    Objective To explore the effect of Dahuang (rhubarb) Granule on intestinal microecological changes in rats with chronic renal failure. Methods The 5/6 nephrectomy model was used as chronic renal failure model, and randomly divided into sham operation group, model group, and low-dose, medium-dose, high-dose Dahuang (rhubarb) Granule groups. After 4 weeks, the body weight, blood urea nitrogen (BUN), and blood creatinine (Crea) levels of each group were measured. Four key intestinal bacteria (including E.coli, Enteroroccus, Lactobacillus and Bifidbacteria) were cultured and quantified with the real-time qPCR method. Expression of colonic proteins claudin-1 and occluding was detected with immunohistochemical method. Indole sulfate (IS) and lipopolysaccharide (LPS) levels were detected with liquid chromatography-mass spectrometry and LPS Reagent method. Results Compared with the sham operation group, in the model group renal function indexes of blood urea nitrogen (BUN) and blood creatinine (Crea) were significantly increased ( P>0.05); the pathogenic bacteria E.coli and Enteroroccus were significantly increased in the model group ( P>0.05), and the probiotics Bifidbacteria was significantly reduced ( P>0.05); the levels of claudin-1 and occludin in the colonic epithelium were significantly reduced; the serum IS and LPS levels were significantly increased ( P<0.05). Compared with the model group, in the low-dose, medium-dose and high-dose Dahuang (rhubarb) Granule groups, the levels of BUN and Crea were significantly reduced ( P>0.05); in the high-dose group, the number of E.coli and Enteroroccus was reduced ( P<0.05), while the amount of Bifidbacteria was significantly increased ( P<0.05); the expression of claudin-1 and occludin in colonic epithelium was significantly increased in all Dahuang (rhubarb) Granule groups ( P<0.05); IS and LPS levels were significantly decreased in the medium-dose and high-dose Dahuang (rhubarb) Granule groups ( P<0.05). Conclusion Dahuang (rhubarb) Granule seems to regulate the intestinal microecology in rats with chronic renal failure through regulating the intestinal flora, including increasing the probiotic Bifidbacteria and reducing the pathogenic bacteria E.coli and Enteroroccus, increasing the expression of intestinal mucosal compact proteins claudin-1, occludin, and reducing intestinal toxin IS and endotoxin LPS levels, which potentially improves renal function in rats with chronic renal failure.
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    Relationship between the essence of male reproduction and conception based on “kidney governing reproduction” *
    Shi Zhongyu, Chen Xiaoying, He Changhao, Zhang Xiaomeng, Wang An, Wang Lei, Hu Sumin
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (2): 108-113.   DOI: 10.3969/j.issn.1006-2157.2021.02.003
    Abstract209)      PDF(pc) (821KB)(69)       Save
    After thoroughly studying the TCM literature related to the theory of “kidney governing reproduction”, in this paper, the difference between male reproductive essence and kidney essence are analyzed; and based on that, the relationship between male reproductive essence and conception are discussed. The basis of “kidney governing reproduction” is the theory of “kidney storing essence” in visceral manifestation theory, which mainly refers to the kidney’s nature of housing both the innate and acquired essence and essence of zang-fu organs. While the theory of “kidney governing reproduction” is mainly reflected in two aspects. One is the close relationship between the kidney and male reproductive organs; the other is that the kidney can regulate reproductive function of the body by adjusting the essence and qi in the kidney. The differences between the male reproductive essence and kidney essence lie in both their functions and location of storage. Kidney essence, which is stored in the kidney, works to not only nourish and maintain the physiological function of the kidney, but also serves as the material basis for the transformation and generation of male reproductive essence. On the other hand, the male reproductive essence, which of reproductive function and stored in the essence chamber, is to be excreted from the body to join with the female reproductive essence for conception. In a word, the conception and forming of fetus is based on the combination of the male reproductive essence and the female reproductive essence. Therefore, the health of male reproductive essence is a necessary factor for the formation of a fetus, and its abnormality will lead to the deficiency of fetal endowment.
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    On therapeutic characteristics of Shibing Lun and application of Lei’s moyuan-diffusing method
    Huang Ting, Ma Huimiao, Guo Yantong, Cheng Zhiqiang
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (10): 804-808.   DOI: 10.3969/j.issn.1006-2157.2020.10.002
    Abstract196)      PDF(pc) (1228KB)(119)       Save
    Shibing Lun (Treatise on Seasonal Diseases) is a monograph on seasonal diseases written by Lei Feng, a famous epidemiologist in the Qing Dynasty. The book recorded experiences of predecessors’ formulas combining with Lei’s own clinical experiences. This paper summarized the academic ideas and characteristics of the monograph, which are stressing therapeutic methods rather than formulas and adapting therapeutic methods according to changing pathogenesis. Furthermore, this paper also analyzed Lei’s moyuan-diffusing method which is based on Wu Youke’s principle of Dayuan Yin (Moyuan-Diffusing Decoction), and made a comparison between the two methods from three aspects, including background of preparation, the symptoms of different patterns, and the composition of prescriptions. It is found that this method is in alignment with the treatment methods used for Corona Virus Disease 2019 (COVID-19), which also proves that adjusting therapeutic methods according to pathogenesis is the key of the theory. Lei learned from the knowledge of the past without being bound by it, and used his own judgement in the treatment. His academic thought not only has far-reaching influences on shaping clinical thinking of doctors today, but can be used for reference in containing the prevalence of COVID-19. Moreover, many published articles have confirmed that moyuan theory is indeed enlightening in the treatment of COVID-19, which deserves further exploration.
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    Regulation of input protein α3/NF-κB pathway by adjusting miR-181 with dissipating phlegm and removing blood stasis method and its anti-atherosclerosis mechanism *
    Qin Hewei, Li Yanjie, Zhang Zhixin, Ji Lingshan, Guo Ning
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 653-660.   DOI: 10.3969/j.issn.1006-2157.2020.08.007
    Abstract193)      PDF(pc) (2238KB)(81)       Save
    Objective To observe the correlation between the anti-atherosclerosis mechanism of dissipating phlegm and removing blood stasis method and the effect on the input protein α3/NF-κB signaling pathway through the regulation of microribonucleic acid 181 (miR-181). Methods In vitro experiments, vascular endothelial cell injury model was established with oxidized low-density lipoprotein (ox-LDL). According to different intervention methods, cells were randomly divided into four groups: model group (blank serum), miR-181 mimic group, miR -181 inhibitor group, phlegm-resolving and blood stasis-eliminating TCM serum group (TCM serum group). After intervention, the cell activity of each group was detected. RT-PCR and Western blot were used to detect the mRNA and protein expression levels of miR-181, input protein α3 and NF-κB. In vivo experiments, 60 ApoE -/- mice were randomly divided into 5 groups: model group, miR-181 inhibitor group, miR-181 mimic group, high-dose and low-dose phlegm-resolving and blood stasis-eliminating TCM serum group (TCM high-dose serum group, and TCM low-dose serum group respectively) ( n=12). After continuous intervention for 8 weeks, the plasma and aorta were collected for testing. The levels of IL-6, VCAM-1 and E-selectin in the peripheral plasma were tested by ELISA. The expression of microRNA-181, input protein α3 and NF-κB in the aortic wall of each group was tested by RT-PCR, and the pathological changes were observed. Results In vitro experiments, the cell activity of the TCM serum group and the miR-181 mimic group was significantly increased ( P<0.05), and the expression of α3 and NF-κB mRNA were significantly down-regulated ( P<0.05). In vivo experiments, compared with the model group, the plasma levels of IL-6, VCAM-1 and E-selectin in the TCM high-dose and low-dose serum groups and miR-181 mimic group were significantly lower, compared with the model group ( P<0.05); compared with the inhibitor group, the levels of peripheral plasma IL-6, VCAM-1 and E-selectin in the TCM serum group were lower ( P<0.05). Compared with the model group, the mRNA expression of aortic miR-181 in the TCM high-dose and low-dose serum groups and miR-181 mimic group was significantly increased ( P<0.05), and the expression level of α3 and NF-κB significantly down-regulated ( P<0.05). There was no significant difference in the indexes between the TCM high-dose and low-dose serum groups ( P>0.05). Conclusion The anti-atherosclerosis mechanism of resolving phlegm and eliminating blood stasis may be related to the targeted regulation of miR-181 to affect the input protein α3/NF-κB signaling pathway, which could possibly reduce the levels of inflammatory mediators such as IL-6, VCAM-1 and E-selectin, thus reducing the damage of vascular endothelial cells.
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    Treatment of stomach yang deficiency pattern in yang-deficiency constitution with classical formulas based on Ye Tianshi’s medical records *
    Ma Han, Wang Qi, Guo Wenqian, Wan Jinyi, Yao Haiqiang
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (1): 78-82.   DOI: 10.3969/j.issn.1006-2157.2021.01.013
    Abstract192)      PDF(pc) (692KB)(194)       Save
    Yang-deficiency constitution is one of the nine basic types of constitution in traditional Chinese medicine (TCM),with yang-deficiency of the spleen and stomach disorders as the main pattern that is frequently observed in clinical practices.The ancient practitioners usually used middle yang to refer to the spleen and stomach yang,or simply used spleen yang only while omitting the stomach yang.However,the physiological and pathological characteristics,and treatment methods of the spleen and stomach are different.Ye Tianshi advocated differentiated treatment for spleen and stomach and paid particular attention to body constitution.This paper analyzed the pathogenesis,pattern,therapeutic methods and classical formulas of stomach yang deficiency used by Ye Tianshi for yang-deficiency constitution;and expounded on different levels of therapeutic methods with specific medical cases combined,such as activating and tonifying stomach qi using Da Banxia Tang (Major Pinellia Decoction) and activating and warming stomach yang using Fuzi Jingmi Tang (Aconite and Rice Fruit Decoction),etc.The rules of pattern differentiation and treatment for stomach yang deficiency was summarized with differentiation of constitution,disease,and pattern combined,which might provide reference for clinical diagnosis and treatment of the spleen and stomach diseases.
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    Solutions and advantages of TCM constitution to problems in comprehensive healthcare *
    Wang Qi
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (3): 197-202.   DOI: 10.3969/j.issn.1006-2157.2021.03.001
    Abstract191)      PDF(pc) (948KB)(109)       Save
    With the development of economy, society, and China's national health strategy, people pay more and more attention to health problems. This paper provides new elaboration of the definition of comprehensive healthcare, points out some problems and macro countermeasures of comprehensive healthcare, and focuses on the role and advantages of TCM constitution theory in comprehensive healthcare. The paper discusses the relationship between TCM constitution and preventive medicine from the following three perspectives. First, constitution type identification is the starting point of preventive medicine. Second, the correlation between constitution and disease provides the basis for preventive medicine. Third, adjustment of constitution is the means of preventive medicine. Based on such relationship, TCM constitution is widely used in the prevention and control of chronic diseases and public health services. The proposal of the health plan based on the nine types of TCM body constitution provides a way for TCM constitution theory to address problems of comprehensive healthcare.
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    Effects of Houshiheisan Formula on the recovery of neurovascular function in rats with cerebral ischemia based on MRI *
    Cheng Hongfa, Wang Xuan, Zhang Yawen, Zhao Hui, Wang Lei, Zou Haiyan, Zhang Qiuxia
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 680-688.   DOI: 10.3969/j.issn.1006-2157.2020.08.011
    Abstract190)      PDF(pc) (3284KB)(115)       Save
    Objective To non-invasively assess the therapeutic effect of Houshiheisan (HSHS) Formula on the recovery of neurovascular function after cerebral ischemia in rats with application of magnetic resonance imaging (MRI). Methods Focal cerebral ischemia model was induced by permanent middle cerebral artery occlusion (pMCAO) in male sprague-Dawley (SD) rats. Then the rats were randomly divided into 5 groups: sham group, model group, HSHS low-dose group (5.25 g/kg), HSHS high-dose group (10.50 g/kg) and Ginkgo biloba extract group (28 mg/kg). Nurological score was assessed after surgery to evaluate the degree of nervous function defects. T2 weighted imaging (T2WI) and T2 relaxation imaging were used to measure the volume of cerebral infarction and the degree of brain tissue damage in rats with cerebral ischemia. Arterial spin labeled perfusion weighted imaging(ASL-PWI)and magnetic resonance angiography (MRA) were used to evaluate the hemodynamic changes of intracranial vessels. Results Compared with the model group, HSHS high-dose group and Ginkgo biloba extract group decrease neurological function score on the 5th and 7th day ( P<0.05). Compared with the model group, the infarct volume reduced and the damage of white matter and gray matter was decreased, and the cerebral blood flow and signal intensity of ischemic hemisphere increased in all treatment groups ( P<0.05). Compared with the sham group, the cerebral blood flow and signal intensity of ischemic hemisphere decreased in the model group ( P<0.01). Conclusion HSHS seems to alleviate brain injury and improve the intracranial hemodynamics, and promote the recovery of neurovascular function.
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    Effect of Yiqi Yangxue Shugan Formula on glutamate-induced RGC-5 cell injury model *
    Li Tiantian, Zhou Jian, Yan Xiaoling, Su Yan, Zhou Xiaoyu, Wei Qiping
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 661-667.   DOI: 10.3969/j.issn.1006-2157.2020.08.008
    Abstract188)      PDF(pc) (2234KB)(76)       Save
    Objective To evaluate the effect of Yiqi Yangxue Shugan Formula (also known as Qing Mang Yi Hao Formula, QMYH) on inhibiting apoptosis of RGC-5 cells by detecting the apoptosis rate in RGC-5 glutamate-induced injury model and related mechanism. Methods Staurosporine (STSN) was used to differentiate RGC-5 cells in vitro. Sodium L-glutamate was used to establish RGC-5 cell apoptosis model, and the cell culture medium containing QMYH serum was used for intervention. CCK-8 Kit was used to detect the survival rate of RGC-5 cells in each group; flow cytometry was used to detect the apoptosis rate of cells in each group; Western-blot was used to analyze the expression levels of Bcl-2/Bax signaling pathway-related proteins in RGC-5 cells; RT-PCR detected the mRNA expression levels of Bcl-2 and Bax. Results Intervention with 0.125 μmol/L STSN medium for 1 h could induce RGC-5 neuronal differentiation. 8 mmol/L sodium L-glutamate interfering for 18 h could cause 50% of RGC-5 cells injury. The medium-dose QMYH group (5% QMYH group) had the highest survival rate of RGC-5 cells (51.1%) and the lowest apoptosis rate (3.9%); compared with the low-dose and high-dose QMYH groups, the mRNA expression level of Bcl-2 in the middle-dose group was obviously up-regulated ( P> 0.05); in addition, the protein Bcl-2/Bax ratio increased significantly. Conclusion The 5% QMYH serum could possibly inhibit the apoptosis of RGC-5 cells by regulating the Bcl-2/Bax signaling pathway.
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    Analysis of “spleen disliking dampness and disgusting dryness” *
    Yuan Yali, Li Xuan, Liu Yong, Niu Xin, Ju Wenxue, Yao Wei
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (2): 114-118.   DOI: 10.3969/j.issn.1006-2157.2021.02.004
    Abstract182)      PDF(pc) (731KB)(141)       Save
    “Spleen liking dryness and disliking dampness” is a common understanding among TCM doctors in all dynasties. Despite that, based on an analysis of the physiological functions and pathological characteristics of spleen in TCM, Professor Bai Changchuan, a nationally famous TCM doctor, puts forward the distinct view of “spleen disliking dampness and disgusting dryness”. In this paper, based on a detailed review of the concepts of “spleen yin”, “spleen dampness”, “spleen disliking dampness” and “spleen disliking dryness” and their dialectical relationships, the connotation of “spleen disliking dampness and disgusting dryness” is elaborated. Specifically, it is pointed out that spleen yin can be damaged due to excessive usage of dry medicinals to eliminate dampness, or bitter dry or bitter cold medicinals, or excessive consumption of spicy food, or excessive thinking, together with root-branch middle qi theory. It is suggested that the treatment of spleen disorders should be aimed at smoothing and moistening. This theory will provide reference for improving the visceral manifestation theory of spleen in TCM and guiding clinical practice.
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    On the connection in thoughts of health maintenance between Zhuangzi and Huangdi Neijing *
    Xi Chongcheng, Xie Ying, Tian Dong, Liu Zhenzhu, Zhang Ning, Liu Jintao, Huang Junwei, Wang Weiguang, Chen Zijie, Zhai Shuangqing
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (11): 892-896.   DOI: 10.3969/j.issn.1006-2157.2020.11.002
    Abstract180)      PDF(pc) (1142KB)(134)       Save
    As the health maintenance thoughts in Zhuangzi and Huangdi Neijing (Huangdi’s Internal Classic) are interlinked,this article compares such thoughts in these two books and summarizes their similarities and characteristics,so as to further reveal the view of life in Zhuangzi and the health maintenance thoughts in Huangdi Neijing (Huangdi’s Internal Classic),thus guiding the further development of TCM health maintenance.It’s found that in terms of the method of health maintenance,both books advocate nourishing the body through combination of dynamic and static status,and nurturing the shen (mind) with a tranquilized and non-active status,with focus on the latter.In terms of the principle of health preservation,both books support conforming to the natural law of life and death,the law of nature and the moderate way,which is regarded as the highest standard of health maintenance.In terms of the relation between the internal and external of the human body,both books maintain that the internal and external of the human body are equally important and should be nurtured and protected together.
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    Study of contraindications in traditional Chinese medicine: pearls for safety evaluation of traditional Chinese medicinals *
    Liao Xing, Hu Ruixue, Chen Wei, Hu Jing, Zhao Hui, Xu Haiyu, Wang Yongyan
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (10): 814-824.   DOI: 10.3969/j.issn.1006-2157.2020.10.004
    Abstract173)      PDF(pc) (1363KB)(89)       Save
    The study of contraindications in traditional Chinese medicine (TCM) aims to improve the efficacy and reduce risks in the diagnosis and treatment in clinical practice. Therefore, contraindication is the essential part to study in traditional Chinese medicine. A firm grasp of contraindications in TCM can help prevent known and unknown risks in clinical practice. TCM practitioners should learn about contraindications, which can promote rational use of Chinese medicines, regulate the behavior of clinicians, improve the effects of medical treatment, and reduce adverse events or adverse reactions. The idea of this paper comes from the book Contraindications in Traditional Chinese medicinals, from which commentary is made to summarize pearls for the safety evaluation of traditional Chinese medicinals. The purpose of this paper is to put forward the notion that TCM contraindications should be taken into consideration throughout the clinical practice of TCM. There are contraindication rules and regulations to follow in the general principle of diagnosis and treatment. We should not ignore them when we are engaged in clinical practice and scientific research of traditional Chinese medicine. Based on the contraindication theory of TCM, two practical and urgent problems need to be solved at present, which are to improve the existing leaflets of traditional Chinese patent medicine and to establish the contraindication database of traditional chinese medicinals in the hospital prescription information system.
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    Effects of Compound Zhebei Extract (CZBE) on the expression of apoptotic protein and xenograft tumors of human colon cancer oxaliplatin-resistant cells (HCT-116/L-OHP) in nude mice: an experimental study *
    Lyu Peng, Dong Qing, Liu Yu, Li Ruibai, Fan Qiuyue, Chen Xinyi, Hou Li
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (10): 834-840.   DOI: 10.3969/j.issn.1006-2157.2020.10.007
    Abstract171)      PDF(pc) (2225KB)(90)       Save
    Objective To observe the inhibitory effect of Compound Zhebei Extract(CZBE) on HCT-116/L-OHP transplanted tumors in nude mice and the expression of apoptotic proteins related to transplanted tumors. Methods HCT-116/L-OHP cells were inoculated into the axilla of BALB/c nude mice to establish L-OHP-resistant transplantation model of colon cancer. After the successful establishment of the model, the transplanted mice were divided into five groups: control group, L-OHP group (3 mg/kg), high-dose CZBE (10 g/kg) combined with L-OHP group, mid-dose CZBE (5 g/kg) combined with L-OHP group, and low-dose CZBE (2.5 g/kg) combined with L-OHP group. Method of administration: CZBE, intragastric administration, once a day; L-OHP, 3 mg/kg, intraperitoneal injection, once every other day for 2 consecutive weeks. At the end of the experiment, the mice were sacrificed and weighed, and then the tumors were removed completely and weighed to calculate the tumor inhibition rate. The tumors were sliced and photographed. Then the effects of CZBE on apoptotic protein expression of HCT-116/L-OHP transplanted tumors were analyzed by using ImageProPlus 7.0 and SPSS21 software. Results CZBE combined with L-OHP could effectively inhibit the growth of HCT-116/L-OHP transplanted tumors in nude mice. The inhibition rate of high-dose CZBE combined with L-OHP group was 45.031%, which was significantly different from that of L-OHP group ( P<0.05). The inhibition rate of mid-dose CZBE combined with L-OHP group was 37.669%. The inhibition rate of low-dose CZBE combined with L-OHP group was 32.147%. The inhibition rate of L-OHP group was 27.239% in the positive control group, and the survival time of transplanted nude mice was prolonged. Compared with L-OHP group, IOD/Area of Bcl-2 cells in low-dose CZBE combined with L-OHP group decreased( P<0.05), while IOD/Area of Bcl-2 cells in mid-dose and high-dose CZBE combined with L-OHP group decreased significantly ( P<0.01). IOD/Area values of Bax in mid-dose CZBE combined with L-OHP group increased ( P<0.05), while IOD/Area values of Bax in high-dose CZBE combined with L-OHP group increased significantly ( P<0.01). Conclusion CZBE combined with L-OHP can improve the tumor inhibition rate of L-OHP-resistant human colon cancer cell lines and prolong the survival time of Oxaliplatin-resistant nude mice. The mechanism may be to reverse multidrug resistance and promote apoptosis of tumor cells by regulating Bax/Bcl-2 apoptotic pathway.
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    Practical aesthetics of psychosomatic medicine in cultivating both the body and mind
    Wang Yongyan, Wang Hao, Wang Zixu
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (2): 104-107.   DOI: 10.3969/j.issn.1006-2157.2021.02.002
    Abstract167)      PDF(pc) (642KB)(57)       Save
    As the original advantages of TCM, “the harmony between the body and mind” and “cultivating both body and mind” embody the holistic view of the principles of Chinese traditional culture. Psychosomatic medicine embodies its practical aesthetics with the idea of cultivating both body and mind and the medical practice, which advocates the beliefs of respecting benevolence and morality, upholding harmony and emphasizing education in traditional Chinese culture. This paper expounds the practical aesthetics of psychosomatic medicine advocating the cultivation of both the body and mind. Firstly, the accumulation of qi forms the body; following the body, shen (mind) generates. The relationship between the body and mind is maintained by “benevolence”, which is the general rule to do a deed. The medical practice of psychosomatic medicine, advocating “the harmony between the body and mind” and “cultivating both body and mind”, embodies the relevance between the body and mind. Secondly, Nourishing shen (mind) requires “keeping a tranquilized mind”, which should be sought in “respect” and cultivating both body and mind. Thirdly, gezhi (studying the nature of phenomena), as one of the carriers of the principles of traditional Chinese culture, guides the understanding of all procedures in TCM diagnosis and treatment by emphasizing “the harmony between the body and mind” and “cultivating both body and mind”. The TCM medical practice, under the guidance of gezhi, reflects the natural beauty of human beings, and the beauty of human nature with physical and mental health, which advocates human relations, respects benevolence and morality, advocates harmony and emphasizes education.
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    Clinical effect of Xingpi Jieyu Formula on mild to moderate depression of liver depression and spleen deficiency pattern *
    Li Yang, Guo Rongjuan, Zhao Zhonghui, Yu Yao, Guo Jianyou, Yuan Qingjie
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (1): 83-91.   DOI: 10.3969/j.issn.1006-2157.2021.01.012
    Abstract167)      PDF(pc) (914KB)(79)       Save
    To study the effects of Xingpi Jieyu Formula on mild to moderate depression of liver depression and spleen deficiency pattern. Methods 61 patients with depression of liver depression and spleen deficiency pattern who volunteered to participate in the study from July 2018 to January 2019 were randomly divided into control group (30 cases) and experimental group (31 cases) according to the time sequence.The control group was treated with placebo ( Xingpi Jieyu granule simulant) and the experimental group was treated with Xingpi Jieyu formula granules.Both groups took 1 dose daily and took separately in the morning and afternoon After 6 weeks of treatment,HAMD-24,HAMA,SDS,SAS,TCM syndrome factor scale scores of depression were compared between the two groups,and the changes of ATP,ADP,amp contents in peripheral blood of the two groups before and after treatment,as well as the occurrence of adverse reactions were compared. Results In terms of clinical efficacy:compared with before treatment,the total scores of HAMD-24,five factor scores of “anxiety/somatization,cognitive impairment,day and night change,block and sense of despair”,SDS score,qi deficiency and qi stagnation pattern scores were reduced in the control group ( P<0.05);the total scores of HAMD-24,six factor scores,gastrointestinal and general symptoms,HAMA total scores,somatic and psychological scores,SDS score,SAS score,and pattern scores of qi deficiency,qi stagnation and phlegm dampness were significantly lower than those before treatment in the experimental group ( P<0.05).The total effective rate of HAMD score was 93.55% (70.97% markedly effective).In terms of mechanism of action:compared with before treatment,peripheral serum AMP increased in the control group ( P<0.05);ATP increased in the experimental group after treatment ( P<0.05);in terms of safety profile,1 patient in control group had nausea,and 2 patients in the experimental group had nausea diarrhea.All symptoms disappeared on its own shortly (2-3 days).No cases of liver and kidney injury. Conclusion Compared with placebo, Xingpi Jieyu Formula could significantly improve depression and somatic symptoms of depressive patients,and can increase peripheral blood ATP level.
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    Interpretation of “pills” in the line “the doctor purged it with pills” *
    Song Qiumeng, Liu Ning, Jia Chunhua
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (10): 809-813.   DOI: 10.3969/j.issn.1006-2157.2020.10.003
    Abstract166)      PDF(pc) (1223KB)(196)       Save
    Regarding the meaning of the line “the doctor purged it with pills” in Shang Han Lun (Treatise on Cold Damage Diseases), there have been various speculations since ancient time, but no detailed interpretation could be traced. Based on the original text and its context, this article attempted to analyze the nature, action, and composition of “pills” combined with previous annotations. It is deduced that those “pills” might be a class of purgatives that contain violent and even toxic drugs with pungent properties, and their indication is possibly constipation caused by unresolved exterior pathogenic factors entering the exterior of the body. Based on such deduction, two classical medical books of Wai Tai Mi Yao (Arcane Essentials from the Imperial Library) and Qian Jin Yao Fang (Important Formulas Worth a Thousand Gold Pieces) are searched to find corresponding prescriptions, namely, Shenshi Kuaichi Pill, Gujin Luyan Xuming Pill and Kuaichi Pill.
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    Correlation between phlegm pattern of metabolic syndrome, fat mass and obesity-associated (FTO) gene *
    Li Yuanyuan, Zhang Ping, Xu Chaoqiang, Li Dan, Chen Shujiao, Gao Bizhen
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 689-695.   DOI: 10.3969/j.issn.1006-2157.2020.08.012
    Abstract164)      PDF(pc) (1229KB)(64)       Save
    Objective To analyze the expression of fat mass and obesity-associated (FTO) genes in the peripheral blood of patients with phlegm pattern of metabolic syndrome (MS) and non-phlegm syndrome, and its correlation with elements and physicochemical index of phlegm pattern, so as to explore the genetic basis of MS phlegm pattern, and provide microcosmic index for the TCM diagnosis of MS phlegm pattern. Methods According to the method of “element-based pattern differentiation”, MS patients were divided into phlegm pattern group and non-phlegm pattern group ( n=35), and 35 healthy people were recruited as the control group. The peripheral venous blood was collected for biochemical examination, and the expression of FTO gene mRNA and protein in human whole blood and serum were detected by real-time fluorescence quantitative PCR (probe method) and enzyme-linked immunosorbent assay (ELISA) method respectively. Results ① The relative expressions of FTO mRNA from high to low were phlegm pattern group > non-phlegm pattern group > control group, and the difference between the three groups was statistically significant ( P<0.05); ② The expressions of FTO protein from high to low were control group > non-phlegm pattern group > phlegm pattern group, and the difference between the three groups was statistically significant ( P<0.05); ③ The uric acid (UA) and BMI in the phlegm syndrome group were positively correlated with the score of phlegm pattern elements ( P<0.05, P<0.01), and the alanine transaminase (ALT) in the non-phlegm pattern group was positively correlated with the score of phlegm pattern elements ( P<0.01); ④ FTO mRNA expression was positively correlated with low-density lipoprotein (LDL-C) in the phlegm pattern group ( P<0.05), positively correlated with aspartate aminotransferase (AST) in the non-phlegm pattern group ( P<0.01). FTO mRNA expression was negatively correlated with Urea nitrogen (BUN) in the non-phlegm pattern group ( P<0.05), and negatively correlated with LDL-C in the phlegm pattern group ( P<0.05). Conclusion The high expression of FTO gene mRNA may increase the risk of phlegm pattern formation in MS. The concentrations of UA, BMI and LDL-C in the phlegm pattern group and the concentrations of ALT, AST and BUN in the non-phlegm pattern group may be related to the high expression of FTO gene. FTO gene could possibly be used as an auxiliary indicator for the diagnosis of phlegm pattern.
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    Discussion on pathogenesis of “wind-induced” atherosclerosis *
    Han Wenbo, Sun Aijun, Li Hongmei, Wang Xian
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (11): 965-968.   DOI: 10.3969/j.issn.1006-2157.2020.11.012
    Abstract160)      PDF(pc) (1071KB)(72)       Save
    Qi deficiency and blood stasis is one of the key pathogeneses of atherosclerosis in the stable period.In the acute episode,atherosclerosis is often characterized by abrupt onset,rapid progress and multiple changes in clinical manifestations.It is similar to the wind pattern in TCM,which is difficult to be fully interpreted from the perspective of qi deficiency and blood stasis.Therefore,in this article the pathogenesis of atherosclerosis of “qi deficiency and blood stasis as the basis,and being further induced by wind” is put forward,which would possibly be the key pathogenesis affecting the progression and outcome of atherosclerosis.
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    Ancient names and theoretical connotation of “menstruation” *
    Wang Zilu, Wang Yanfei, Shi Wei, Li Guangwen, Wang Dongmei, Liu Jinxing
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (3): 226-231.   DOI: 10.3969/j.issn.1006-2157.2021.03.006
    Abstract160)      PDF(pc) (830KB)(64)       Save
    There were many terms with different meanings to refer to menstruation in ancient books on Chinese medicine. To sort out the changes in the names of menstruation and their connotations is very important for correct understanding of the theoretical connotations of menstruation in medical literature. This article reviews a wide range of literature ranging form the four major TCM classics to important literature related to TCM gynecology in the Ming and Qing dynasties, collects and summarizes the names and interpretations of menstruation, and identifies four different theoretical connotations of the names of menstruation in different literature. Some names describe the phenomenon of uterine bleeding, some emphasize the periodic physiological phenomena of uterine bleeding, some refer solely to the blood discharged during menstruation and others mean the fine substances that run in the body to nourish the body.
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    Understanding the “eight extraordinary meridians system” in the Case Records as a Guide to Clinical Practice based on the theory of “six compartments of yin and yang” *
    Chen Xu, Jia Bo
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (10): 825-829.   DOI: 10.3969/j.issn.1006-2157.2020.10.005
    Abstract159)      PDF(pc) (1168KB)(157)       Save
    The pattern identification of the eight extraordinary meridians reflected in the book titled Lin Zheng Zhi Nan Yi An (Case Records as a Guide to Clinical Practice) includes the theories of “six compartments of yin and yang”, “triple jiao” and “branch, root and center of six qi” in Huangdi Neijing, align with Ye Tianshi’s theory of “defense-qi-construction and blood” and “triple jiao”. The common route of Taichong meridians is from the bottom to the top, or from the root of Shaoyin through Yangming to the top of Guangming, crossing three jiao and three compartments, supplied with defense, qi, nutrient and blood by all the meridians. The essential qi is thus vaporized upwards to the brain. The defensive qi of all zang-organs in the triple jiao diverges into two pathways: one outside the vessels, or defensive qi goes out of triple jiao and flows into six fu organs; the other infusing into the vessels and converge at the extra meridians. The extra meridians are similar to lakes and rivers. They echo with the solitary organ of triple jiao. Interiorly, extra meridians unite the defense, qi, nutrient and blood, govern the three yin and three yang meridians to harmonize yin and yang, harmonize the essential qi and unite six qi; whereas exteriorly, triple jiao governs the defense, qi, fluids and humor, so as to balance heat and cold as well as yin and yang. When extra meridians and triple jiao are harmonious interiorly and exteriorly, yin-yang balance is achieved. By establishing the extra meridian system of Ye Tianshi, it can be used as reference to help us understand the physiology and pathology of traditional Chinese medicine, as well as predict, prevent, diagnosis and treatment of diseases.
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    Mechanism of paeoniflorin on LPS-induced human chondrocyte inflammation and degeneration based on NF-kB signaling pathway *
    Chen Pu, Ruan Anmin, Zhou Jun, Zhang Xiaozhe, Ma Yufeng, Wang Qingfu
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (11): 903-909.   DOI: 10.3969/j.issn.1006-2157.2020.11.004
    Abstract157)      PDF(pc) (1206KB)(84)       Save
    Objective To observe the effects and explore the mechanism of paeoniflorin (PF) on the inflammation and degeneration of LPS-induced human chondrocytes. Methods Discarded cartilage tissues from primary knee osteoarthritis (KOA) patients undergoing total knee arthroplasty at The Third Affiliated Hospital of Beijing University of Chinese Medicine from April 2019 to October 2019 were collected and digested into chondrocytes using pancreatin and collagenase.The effect of different concentrations of PF on the viability of chondrocytes was detected using the CCK-8 assay,and appropriate concentrations were selected for subsequent experiments.Chondrocytes were randomly divided into five groups,namely the blank group,the model group,and the low,medium,and high concentration PF intervention groups.Except for the blank group,chondrocytes in the other four groups were induced by LPS to simulate an arthritis environment.In the low,medium,and high concentration PF intervention groups,10,20,and 50 μMol/L PF were given respectively.The expressions of IL-1β,IL-6,TNF-α,MMP13 and ADAMTS5 in each group were detected by qPCR assay;and the expression levels of NF-kB p65,IKB and IkK were detected by Western-blot. Results The results of CCK-8 assay showed that 10,20,and 50 μMol/L PF could significantly increase the level of proliferation and viability of human chondrocyte;while excessively high concentration (200 μM) PF could inhibit chondrocyte viability.Further qPCR results showed that PF could significantly inhibit the expression levels of inflammatory factors IL-1β,IL-6,TNF-α and cartilage degradation factors MMP13 and ADAMTS5 in human chondrocytes after LPS intervention,compared with the model group ( P<0.05);WB results showed that PF could significantly inhibit NF-kB p65 and IkK expresion and promotes IkB expression ( P<0.05). Conclusion Paeoniflorin seems to inhibit LPS-induced human chondrocyte inflammation and delay cartilage degeneration by inhibiting the activation of NF-kB signaling pathway.
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    Clinical significance of the statement “the use of all needling methods must be based on shen” as guidance for acupuncture practice *
    Chang Yu, Ma Tieming
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (10): 876-880.   DOI: 10.3969/j.issn.1006-2157.2020.10.013
    Abstract156)      PDF(pc) (1227KB)(125)       Save
    The line “all needling methods must be based on shen (spirit or vitality) originates from the chapter entitled Ben Shen in Lingshu (Miraculous Pivot). This statement indicates that basis of shen plays vital role in acupuncture therapy. Treating the shen of the patients is the perquisite key to the effectiveness of acupuncture treatment and this thought should be maintained in the acupuncture clinical practice. By reviewing, analyzing and interpreting all relevant literature by ancient practitioners, this paper offers a summary of the meaning of this statement. During acupuncture therapy, acupuncturists should maintain their own shen and treat patients in an intensive focused state. Meanwhile, patients should also calm down and nurse their internal shen to properly respond to acupuncture intervention and achieve desired effectiveness. These two aspects need to be coordinated to arrive at the goal of treating both physique and mind. From the perspective of rationale, methods and techniques of treating shen, this paper elaborates on how to apply acupuncture on the basis of treating shen by giving details on how to evaluate, regulate, maintain and calm shen, Serving reference to the improvement of acupuncture effectiveness.
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    TCM analysis of tongue characteristics in 3,211 patients with metabolic syndrome based on multicenter database *
    Zhu Xiaoyun, Tang Yang, Zhu Lili, Feng Lei, Liu Ximing
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (10): 849-858.   DOI: 10.3969/j.issn.1006-2157.2020.10.009
    Abstract151)      PDF(pc) (1215KB)(76)       Save
    Objective To analyze the characteristics of tongue in patients with metabolic syndrome (MS) and provide evidence and support for the correlation between TCM pattern differentiation based on tongue characteristic and basis of human biology. Methods Data of MS patients’ tongue images and their physical and chemical examination results were extracted from MS clinical epidemiological investigation database. SPSS17.0 software was used for descriptive statistical analysis and stepwise logistic regression of the data. Results 3,211 MS patients were included in the study with a male-to-female ratio of 1.06∶1. The number of patients with abnormal levels of blood lipids, blood pressure (BP) and fasting plasma glucose (FPG) was the largest (1,050), accounting for 32.70%. The number of those with abnormal levels of blood lipids and BP and normal levels of FPG came next (1,010), accounting for 31.45%, followed by the number of cases with abnormal levels of FPG and BP and normal levels of blood lipids (719), accounting for 22.39%. The average age of the patients was 53.86±10.33 with the majority aged from 40 to 69. The age distribution of men is younger than that of women. The most frequently observed abnormal tongue shapes were enlarged tongue (32.4%), cracked tongue (14.2%) and teeth-marked tongue (11.0%). In terms of tongue color, red tongue (38.2%) was the most frequently encountered, followed by pale tongue (17.0%) and light purple tongue (15.1%). Varicose sublingual vein cyanosis (14.4%) was also seen at a high frequency. The colors of tongue coatings were mainly yellow and white, accounting for 53.9% and 46.0% respectively. Most of the tongue coatings were thin (37.6%), greasy (36.8%) or thick (25.4%). Logistic regression showed that increase in blood pressure was significantly related to enlarged tongue, red and crimson tongue, stasis macules and spots on the tongue, varicose sublingual vein cyanosis and thin tongue coating, etc. Abnormal levels of blood lipids were significantly correlated with light purple tongue, varicose sublingual vein cyanosis, greasy tongue coating, thick tongue coating and glossy tongue coating. Increase in fasting blood glucose was positively related to pale tongue. However, there was a negative correlation between blood glucose and varicose sublingual vein cyanosis, moist tongue coating and glossy tongue coating. Meanwhile, there was a close relationship between changes in tongue image and patients’ physical and chemical examination results. Deep tongue color, stasis macules and spots on the tongue and varicose sublingual vein cyanosis were related to significant increase in blood viscosity. Conclusion Tongue images of MS patients of different types demonstrate different characteristics. Most of them present excess pattern with blood stasis featuring deep tongue color, stasis macules and spots on the tongue and varicose sublingual vein cyanosis. There is consistency and correlation between tongue image and pathogenic factors, physical and chemical examination results and hemorheological parameters of patients with MS, which reflects the influence of multiple factors on MS. The present findings can provide Objective basis for clinical diagnosis and treatment of MS.
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    Challenges and solutions in the establishment of rat models of gastritis deteriorating into gastric carcinoma *
    Ding Xia, Su Zeqi, Shen Hong, Zhang Ping
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (12): 973-979.   DOI: 10.3969/j.issn.1006-2157.2020.12.001
    Abstract151)      PDF(pc) (1483KB)(66)       Save
    Since “deterioration of chronic gastritis into gastric cancer” is the main cause of gastric cancer, active prevention and treatment of such deterioration is of great significance for reducing the incidence of gastric cancer. However, many bottlenecks in model establishment have restricted the development of basic research and application in this field, e.g. the selection of model factors, model preparation methods, model evaluation at different pathological stages, the way of combining WM disease and TCM pattern in model establishment, and model pattern determination. Based on the research findings of the present team in the last 5 years as well as global research progress, problems in the establishment of the animal models of gastritis deteriorating into gastric carcinoma with consideration of both WM disease and TCM pattern were analyzed one by one and possible solutions were proposed. We simulated the clinical features of the multifactorial disease and provided two rat models with MNNG as the main factor. Compared with the existing models, they are proved more in line with clinical characteristics of the disease and yield higher success rates for model establishment and better stability by multiple experiments. They may become powerful tools for animal research in this field.
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    Equally prioritized and integrated approach to Chinese and Western medicine faciliates the blossoming development of traditional Chinese medicine
    Wang Yongyan
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (1): 5-8.   DOI: 10.3969/j.issn.1006-2157.2021.01.001
    Abstract151)      PDF(pc) (840KB)(92)       Save
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    Analysis of mechanism of inflammation-cancer transformation from damp-heat theory *
    Tian Lin, Lin Cuili, Sun Yueming, Ke Xiao, Huang Minghan, Yang Chunbo
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (3): 215-220.   DOI: 10.3969/j.issn.1006-2157.2021.03.004
    Abstract151)      PDF(pc) (752KB)(66)       Save
    Damp-heat is a common pathogenic factor clinically, which is characterized by stickiness and greasiness. Inflammatory cells and inflammatory mediators constitute the local inflammatory microenvironment. The formation, invasion and metastasis of tumors are based on the persistent existence of inflammatory microenvironment. The characteristic stickiness of damp-heat suggests that it may be an important factor for the persistent and refractory inflammatory microenvironment. At the same time, the transformation into toxin from dampness-heat pathogenic qi is similar to the inflammation-cancer transformation, and there is a close relationship between them. The main pathogenic substances of tumor, such as phlegm and stasis, are essentially from the source of damp-heat, which participates in the whole process of the inflammation-cancer deterioration as an initiating factor. Therefore, on the basis of analyzing the etiology and pathogenesis of inflammatory microenvironment, this paper discusses in-depth the pathological mechanism of the inflammation-cancer transformation from the perspective of the damp-heat theory, providing important theoretical basis for clinical diagnosis and treatment.
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    Discussion on “deqi” and “qizhi” in moxibustion *
    Peng Ruoxuan, Mao Hongrong, Wu Sai
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (12): 1042-1045.   DOI: 10.3969/j.issn.1006-2157.2020.12.011
    Abstract150)      PDF(pc) (625KB)(54)       Save
    The concepts “deqi” (literally, obtaining qi) and “qizhi” (literally, arrival of qi) are not unique to acupuncture, but also relevant in moxibustion. They refer to two characteristic manifestations in the process of moxibustion therapy. “Deqi” is mainly characterized by reddening of local skin accompanied with aching distention and hot pain caused by moxibustion, but these sensations might indicate the arrival of healthy qi or pathogenic qi, and thus may not necessarily suggest the arrival of qi that cures. On the other hand, “qizhi” often involves effective relief of superficial symptoms and improvement of pulse manifestation on the basis of “deqi” clinically. For different patterns, and with different moxibustion methods, acupoints, and supplementation/drainage manipulations, the characteristics and relationships between “deqi” and “qizhi” may vary. Understanding such subtle differences helps practitioners select the appropriate acupoints and methods according to different patterns during clinical moxibustion, and also assess the efficacy of moxibustion.
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