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    Effects of Yiqi Huoxue formula and Bushen Shengsui formula on expression of Wnt3a,Frizzled9 and TCF3 in hippocampus of rats with ischemia-reperfusion injury *
    SONG Zu-rong,WANG Jian,HU Jian-peng,XU Wei
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (3): 190-194.   DOI: 10.3969/j.issn.1006-2157.2015.03.010
    Abstract763)      PDF(pc) (1126KB)(1685)       Save
    Objective To study the effects of Yiqi Huoxue formula (YQHX) and Bushen Shengsui formula (BSSS) on the protein expression of Wnt3a,Frizzled 9 and TCF3 on Wnt/β-catenin pathway in hippocampus of rat model induced by middle cerebral artery ischemia/reperfusion. Methods The focal cerebral ischemia/ reperfusion rat model was established by intraluminal thread occlusion of the middle cerebral artery (MCAO)for 2-h followed by 7-d reperfusion. The rats were randomly divided into sham group, model group, YQHX group and BSSS group(each n=10). The expression of Wnt3a, Frizzled9 and TCF3 protein in hippocampus of cerebral ischemia were detected by Western-Blot assay,and those in CA1 zone of cerebral ischemia were measured by using immunohistochemistry Envision two-step method. Results The relative expression of Wnt3a,Frizzled 9 and TCF3 protein in both hippocamous and CA1 zone increased significantly in model group compared with sham group ( P<0.01). Compared with model group, the expression of those three proteins in both hippocamous and CA1 zone decreased significantly in YQHX group and BSSS group ( P<0.05). Conclusion Yiqi Huoxue formula and Bushen Shengsui formula can promote the repairment of injured cerebral tissue by the way of reducing the protein expression of Wnt3a,Frizzled9 and TCF3 in hippocampus to regulate Wnt/β-catenin signal pathway.
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    Principles for Formulating Prescriptions Based on Zang-Fu Organs, Origin and Superficiality, Deficiency and Excess, Cold and Heat Syndrome on guiding the clinical use of drugs on treatment of TCM liver diseases *
    ZHANG Limin, CHEN Shaodong
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (1): 13-15.   DOI: 10.3969/j.issn.1006-2157.2017.01.003
    Abstract536)      PDF(pc) (1224KB)(1658)       Save
    Principles for Formulating Prescriptions Based on Zang-Fu Organs, Origin and Superficiality, Deficiency and Excess, Cold and Heat Syndrome is one of ZHANG Yuansu’s famous masterpieces. With decades of clinical experience, ZHANG Yuansu summarized his own pathogenesis theory corresponding to Zang-Fu organs, cold and heat syndrome, deficiency and excess syndrome. In his efforts, the theory of differentiation based on Zang-Fu organs was appreciated by doctors of later ages. Conciseness of the prescription and the medication rules on treatment of TCM liver diseases recorded in this book was the fruit of the combination of inheritance of the Classic and his own theoretical innovation. The clinical thought of diagnosis and treatment, including grasping physiological function of zang-fu organs, understanding progression of diseases, tactfully using medicines of guiding action and leading to improving the curative effects, is still of great clinical significance up to now.
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    Discussion on the diagnosis model of disease names of Chinese medicine and Western medicine in TCM practice
    XIANG Ming, LIN Xiang-dong, HE Jun-feng, ZOU Xiao-ling, HUANG Hui-yong
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (7): 447-449.   DOI: 10.3969/j.issn.1006-2157.2015.07.004
    Abstract591)      PDF(pc) (1085KB)(1489)       Save
    The diagnosis model of disease names of Chinese medicine and Western medicine is widely used simultaneously in TCM practice. Undoubtedly, the standard application of disease names of Chinese medicine and Western medicine, shows a style of normalization of TCM diagnosis and treatment. However, some problems still exist in TCM clinical practice, such as less Chinese medicine disease names, lacking of uniform diagnosis standard in TCM practice, application mechanical leading to rigid diagnosis and treatment, and so on. It is suggested that TCM physicians should carry out the diagnosis model of disease names of Chinese medicine and Western medicine according to the situation.
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    Systemically biological characteristics focused on pathogenesis: a novel idea of TCM scientific research *
    PAN Li-qun, YAO Chang, PAN Zi-hao, LI Yong-gang
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (3): 162-166.   DOI: 10.3969/j.issn.1006-2157.2015.03.004
    Abstract690)      PDF(pc) (1059KB)(1368)       Save
    It is inevitable for TCM researchers to find out right ways of TCM scientific research. Through the analysis of confusions faced with, TCM original thoughts with ancient background, practical research in teamwork and systems science, the basic research idea of Chinese medicine is summarized as the following: the core connotation of Chinese medicine presented as the relationship-centered theory, is the dominant position of pathogenesis as well as construction procedure of “Careful Card, Judge for Differentiation”. Regard systemical application of the integration of academic and technologies associated with life sciences as characteristics, we believe that the characteristics should be one of the appropriate routes to clarify the confusion existed in modern TCM research.
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    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2016, 39 (2): 97-100.   DOI: 10.3969/j.issn.1006-2157.2016.02.002
    Abstract459)      PDF(pc) (1070KB)(1357)       Save
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    Origin and development of moxibustion
    GAO Zhiping
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (1): 16-19.   DOI: 10.3969/j.issn.1006-2157.2017.01.004
    Abstract479)      PDF(pc) (1223KB)(1304)       Save
    This paper puts forward the concept of “original moxa-moxibustion” from the perspective of natural cognition. Based on the ancient unique views on the traditional cultural traits of Nature, Asiatic wormwood, lives and diseases, original moxa-moxibustion was the perfect combination of mysterious phenomena with magical strength guided by ancient natural philosophy, and was shared with sorcery, medicine and Taoism. Then the use of fire accompanied by labor practice pushed the popularization of original moxa-moxibustion which transformed into moxa-moxibustion therapy of traditional Chinese medicine, after integrating with traditional medicines on human physiology, pathology and pharmacology, and learning from the technique of stone needles. Original moxa-moxibustion was earlier than moxibustion therapy, because use of fire was earlier than use of medicines. Development and innovation of moxibustion need deep understanding its origin and characteristics, as well as studying traditional culture and modern technology on thinking, techniques, Methods and tools.
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    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (6): 430-432.   DOI: 10.3969/j.issn.1006-2157.2015.06.014
    Abstract555)      PDF(pc) (1067KB)(1294)       Save
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    Allergic diseases and intestinal flora imbalance for allergic constitution research *
    YANG Fei, WANG Ji, WANG Qi
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (8): 509-514.   DOI: 10.3969/j.issn.1006-2157.2015.08.001
    Abstract562)      PDF(pc) (1122KB)(1267)       Save
    Studies have shown that intestinal flora imbalance is closely related with allergic diseases, yet its specific mechanism remains unclear. Modern medicine considers that it may be associated with increased intestinal permeability and intestinal barrier disruption caused by dendritic cells and other immune cells. Traditional Chinese Medicine identifies three possible approaches, which are “Lungs invaded by evil passing to the large intestine”, “Spleen invaded by evil leading to restricted nutrition and disturbed microenvironment” and “Liver invaded by evil leading to stirred-up wind and disturbed microenvironment”. The root cause is that “Pathogenic factor invades when Zheng Qi is deficient”. This paper explores what intestinal flora research can bring to the allergic constitution study by combining the four fundamental theories “Life course theory”, “Composition of form and spirit”, “Environmental constraint theory”, and “Theory of innate endowment”.
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    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (6): 369-372.   DOI: 10.3969/j.issn.1006-2157.2015.06.002
    Abstract471)      PDF(pc) (1079KB)(1191)       Save
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    Inheritance and development of spleen-stomach theory in Huangdi Neijing (Yellow Emperor’s Internal Classic) by Huang Yuanyu *
    Gao Zhili, He Juan
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2018, 41 (11): 890-893.   DOI: 10.3969/j.issn.1006-2157.2018.11.002
    Abstract530)      PDF(pc) (1052KB)(1180)       Save
    Spleen-stomach theory is an important academic thought in Huangdi Neijing ( Yellow Emperor’s Internal Classic). The idea of emphasizing earth was a concrete embodiment of Chinese philosophy in traditional Chinese medicine at that time. Later generations of doctors inherited and developed spleen-stomach theory in Huangdi Neijing, among them, Huang Yuanyu, a physician in the Qing Dynasty, was a particular representative. Huang’s theory of qi circumfluence and four images of earth pivot emphasizes the up-downs and rotation of qi in the middle earth, and stresses ascending of the left-side qi movement. He proposed that damp earth, cold water and wood depression were main pathogenesis of human diseases, which has important influence on later clinical practice.
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    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (9): 591-593.   DOI: 10.3969/j.issn.1006-2157.2015.09.002
    Abstract519)      PDF(pc) (1092KB)(1152)       Save
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    Chinese formula design based on characteristics of formula nature
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE   
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    On the holistic view of the meridian sinew theory *
    LIN Xingxing,DONG Baoqiang
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (10): 808-812.   DOI: 10.3969/j.issn.1006-2157.2017.10.003
    Abstract489)      PDF(pc) (1236KB)(1090)       Save
    Current studies on the essence and theory of the meridian sinews are mainly based on anatomical approaches and lack the holistic view of traditional Chinese medicine (TCM). This paper explores the holistic relationship between the external nature, internal organs, and internal sinews; the inherent relationship between the sinews and qi and blood in movement, function and system; and the balanced relationship between up and down, left and right, front and back, angle and rectangle based on functional line. The authors hold that establishing the theoretical system of meridian sinews should be and must be placed in a multi-dimensional interconnected network so as to break the shackles of current tendon studies.
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    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (11): 729-731.   DOI: 10.3969/j.issn.1006-2157.2015.11.002
    Abstract563)      PDF(pc) (1095KB)(1059)       Save
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    Interpretation of complexities of TCM constitutional theory
    GUO Gang, LYU Ya-Yu, ZHENG Yan-fei, WANG Qi
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (7): 437-440.   DOI: 10.3969/j.issn.1006-2157.2015.07.001
    Abstract647)      PDF(pc) (1166KB)(1050)       Save
    Based on the reasonable interpretation of complexity of human body, TCM constitutional theory is to summarize and abstract Four Basic Principles viz. the theory of physical process, of body-spirit syncretism, of environmental constraint and of genetic endowment. Regarded as the starting points and theoretical basis of studies in TCM constitution, the basic principles mentioned above impling the characteristic complexities of dissipation, integrity, openness, nonlinearity and emergence indicates that they exactly focus on the individual differences and individual diagnosis and treatment, which leads to enrich and improve the development of TCM.
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    Application of non-equilibrium thermodynamical theory in syndrome thermodynamics of TCM *
    LI Hong-juan,WANG Le-peng, WEI Ming,DENG Pin,SUN Tao
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (3): 158-161.   DOI: 10.3969/j.issn.1006-2157.2015.03.003
    Abstract632)      PDF(pc) (1102KB)(1021)       Save
    To interpret the TCM yin-yang theory by introducing the theory of non-equilibrium thermodynamics. By using infrared imaging technology, the regional calorific values on body surface corresponding to viscera and triple-energizer inside were presented on coordinate diagrams. The presentation was called human thermal structure which established the ideas and methods of thermodynamics of TCM syndrome. It put clearly forwards that healthy human thermal structure conformed to the dissipative structure, and the human thermal structure appeared differently in person with different TCM syndrome. So the treatment based on syndrome differentiation is adjustment of regional cold or heat deviation to restore normal human non-equilibrium thermal structure.
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    Application of qualitative interview in cancer intervention by Chinese medicine
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE   
    Abstract1137)      PDF(pc) (834KB)(1014)       Save
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    Analysis of tertiary collateral vessel in Huangdi’s Internal Classic
    LIU Bin,YOU Hai-yan
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (5): 303-305.   DOI: 10.3969/j.issn.1006-2157.2015.05.003
    Abstract592)      PDF(pc) (1138KB)(1012)       Save
    Tertiary collateral vessel (Sun Luo) is a component of meridian and collateral system. It belongs to vessel (Mai) in the five body constituents and is also a branch of collateral vessel. This article discusses the properties of tertiary collateral vessel after reviewing chapters and sections related to tertiary collateral vessel (Sun Luo) and tertiary vessel (Sun Mai) in Huangdi’s Internal Classic (Huang Di Nei Jing). It is found that tertiary collateral vessel is located at the level of flesh (musculature) in five body constituents. A large number of tertiary collateral vessels form a wide range of interconnection in flesh (musculature), integrate Qi with blood, and flow to other structure, with particularly close relationship with Xigu and skin. Tertiary collateral vessel takes part in the circulation of Qi and blood, receives the infusion of nutrient Qi in middle energizer ( jiao), and is a key part of meridian and collateral system for receiving the essence of water and food. The initial findings of the research reveals the complexity of tertiary collateral vessel as well as its distinctiveness in the Qi and blood circulation in human body. It has potential practical value in the diagnosis and treatment of related diseases, as well as in the research of chronomedicine. It is also significant for research on hemorheology of meridian and collateral system through further discussion on the characteristics of the structure and flow of tertiary collateral vessel.
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    Clinical efficacy of TCM formula of replenishing qi and resolving phlegm and dispelling stasis on patients with stable chronic obstructive pulmonary disease *
    WANG Wei,WU Haibin,WANG Qi,ZHANG Yongsheng,HAN Feixiang,LI Jinting
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (11): 777-780.   DOI: 10.3969/j.issn.1006-2157.2015.11.013
    Abstract421)      PDF(pc) (1120KB)(991)       Save
    Objective To evaluate the clinical efficacy of qi-replenishing, phlegm-resolving and stasis-diapelling formula, a Chinese compound medicine, on the patients of stable stage with chronic obstructive pulmonary disease (COPD). Methods Altogether 51 COPD patients with TCM syndrome of deficiency of lung qi, spleen qi, kidney qi and phlegm-stasis obstruction were randomly divided into Chinese medication group ( n=26) and control group ( n=25) .The patients of the control group were treated with only routine Western medication, while those of the Chinese medication group were treated with the routine Western medication combined with TCM formula for consecutive four months. Results There were significant differences of forced expiratory volume in one second (FEV1) , changes of symptom scores and COPD assessment test (CAT) scores between after treatment and before treatment in Chinese medication group( P<0.05). Compared with control group, all the indexes mentioned above showed statistical differences in Chinese medication group( P<0.05). Conclusion The clinical efficacy and safety of Chinese formula were proved by the means of comparison of FEV1, symptom scores and CAT scores between Chinese medication group and control group.
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    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2016, 39 (3): 193-195.   DOI: 10.3969/j.issn.1006-2157.2016.03.004
    Abstract408)      PDF(pc) (1198KB)(989)       Save
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    On clinical application of classic formulas from the formula-pattern and formula-pattern element correspondence *
    ZHENG Fengjie
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (10): 653-657.   DOI: 10.3969/j.issn.1006-2157.2015.10.001
    Abstract483)      PDF(pc) (1250KB)(962)       Save
    Formula-pattern correspondence is a principle for prescribing formula for a specific mechanism. Correspondence between formula and pattern elements (formula-pattern element correspondence is a new principle developed on the basis of formula-pattern correspondence for formulating prescriptions. They are both under the guidance of "treatment according to pattern identification". Exploring the meanings of formula-pattern and formula-pattern element correspondence can help improve flexibility of practitioners and promote standardization of clinical prescription, expand the modern clinical application of classical formulae and improve the therapeutic effects in the treatment of complicated diseases.
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    Ganzhi Yunqi and constitution: correlation and philosophical interpretation *
    HE Juan
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (6): 365-368.   DOI: 10.3969/j.issn.1006-2157.2015.06.001
    Abstract527)      PDF(pc) (1170KB)(937)       Save
    The theory of five circuits (yun) and six climatic factors (qi), an indispensable part of Traditional Chinese Medicine, studies the cycle of climatic changes and its influence on life activities. According to the theory of Huangdi’s Internal classic, The influence of ganzhi (heavenly stems and earthly branches) yunqi on life activity is not limited to the development of diseases or syndromes related to changes of yunqi within corresponding year; this impact also extends to inherent physical constitution determined by the yunqi of pregnancy year. This physical characteristic is also associated with its susceptibility to diseases. Yunqi theory originates from the theory of qi transformation in Huangdi’s Internal classic, which is the extension of qi-monism theory in ancient philosophy.
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    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2016, 39 (10): 820-823.   DOI: 10.3969/j.issn.1006-2157.2016.10.007
    Abstract288)      PDF(pc) (1224KB)(917)       Save
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    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE   
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    Application rules of Xiaoqinglong Decoction based on the modern medical records *
    YANG Shuhui, DING Jishan, ZHI Lin
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (1): 83-88.   DOI: 10.3969/j.issn.1006-2157.2017.01.016
    Abstract377)      PDF(pc) (1191KB)(898)       Save
    Objective To explore the application rules of Xiaoqinglong Decoction in modern clinical practice, in order to provide a new idea and method for ancient Chinese herbal medicine compound to serve the present days. Methods Retrieving CNKI database, eligible 599 articles were selected through the keyword of “小青龙汤”, with remarkable effect and complete clinical information. Altogether 786 cases from the articles were input Excel table. The disease names, symptoms and the herbal medicineswere standardized, and their frequency were analyzed. Then the primary symptoms of Xiaoqinglong Decoction Syndrome were screened by using Golden Section Method, and the symptoms with frequency of 20 or above were performed cluster analysis including hierarchical clustering, Ward method and Pearson dependency. Results There are 68 western disease names and 45 TCM disease names, and 48 symptoms, 46 herbal medicines, 8 tongue texture, 7 tongue coating and 10 pulse manifestion with frequency of 20 or above. As the consequence, six primary symptoms and 17 significant cluster sets were screened. Conclusion Xiaoqinglong Decoction was undoubtedly used for pulmonary diseases including bronchitis, bronchial asthma, as well as cardiac diseases including cor pulmonale, heart failure arisen from pulmonary diseases, and other diseases due to phlegm and fluid retention. The indications of Xiaoqinglong Decoction were listed as cough, asthma, expectoration, white sputum, pale tongue and white tongue coating, with the accompanied symptoms of yang-deficiency syndrome, blood stasis syndrome, exogenous cold syndrome and interior heat syndrome. The basic pathogenesis of Xiaoqinglong Decoction Syndrome was referred as phlegm and fluid retention accumulated in the lung with the disease location of lung, which could aggravate to yang-deficiency in spleen and kidney, blood stasis in heart vessels or interior heat consuming yin.
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    Source tracing of triple energizers *
    ZHANG Tianxing, HE Juan
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (11): 725-728.   DOI: 10.3969/j.issn.1006-2157.2015.11.001
    Abstract423)      PDF(pc) (1252KB)(897)       Save
    According to Huangdi Neijing and Nanjing, the triple energizers (sanjiao), a TCM term, is considered and proved to be the collection of lots of crannies in human body from the aspects of its name, function, shape, characteristics and location. Specifically, sanjiao is composed of three wide crannies below the diaphragm and from which countless tiny crannies extended, that is to say, it is exactly a three-dimensional network performing ying and wei production, qi and blood transportation, water spreading, vital qi communication and original qi transportation. The three wide crannies mentioned above can be considered as the main body of san jiao existed, and the voids in the body is just the position of sanjiao. The paper also tries to explain the fououing issues: sanjiao with name but without form, the relationship between sanjiao and channel, syndrome differentiation of sanjiao.
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    Correlation between structural shifts of gut microbiota and hyperuricemia in quails
    HUANG Sheng-nan, LIN Zhi-jian, ZHANG Bing, GENG Di, NIU Hong-juan, ZHU Chun-sheng, WANG Xue-jie, SUN Bo-yu
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (7): 452-456.   DOI: 10.3969/j.issn.1006-2157.2015.07.006
    Abstract901)      PDF(pc) (1356KB)(869)       Save
    Objective To explore the effect and potential mechanism of gut microbiota on the development of hyperuricemia(HUA). Methods Altogether 48 Difake male quails were randomly diveded into four groups ( n=12 each) according to body weight: normal group(N group), model group(M group), antibiotics and normal diet group(Ab+N group), and antibiotics and high-purine diet group(Ab+M group). Quails in N group and Ab+N group were fed with normal diet, and those of other two groups were fed with high-purine diet; at the same time, quails in N group and M groups drank clean tap water, and those of Ab+N group and Ab+M group drank water containing ampicillin (150 mg/L) and neomycin (75 mg/L) for consecutive 28 days. The microbiota structure of quail gut was determined by PCR-DGGE, while the concentration of endotoxin (LPS) in plasma and cecal content, serum uric acid (UA), xanthine oxidase (XO) activity in serum and liver were measured by automatic biochemical analyzer or multiscan spectrum. Results Compared with N group, the gut microbiota structure of M group changed, as well as the concentration of LPS in plasma and cecal contents, the activity of XO in serum and liver, and serum UA all increased significantly ( P<0.05 or P<0.01); however, the indicators mentioned above showed no significant differences in Ab+N group and Ab+M group ( P>0.05). Compared with M group, the concentration of LPS in plasma and cecal contents, the activity of XO in liver, and serum UA in Ab+N group and Ab+M group all decreased dramatically( P<0.05 or P<0.01). Conclusion High-purine diet induced structural shifts of gut microbiota and HUA in quails. The concentration of LPS, metabolite of gut microbial flora, is positively related to the activity of XO and serum concentration of UA. And the occurrence of hyperuricemia maybe is attributed to activation effect of LPS on XO activity.
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    Fingerprints for characterization of nine compatibility formula and optimization of compatibility formula engaged in activating blood and resolving stasis :a study for Sanhuang Xiexin decoction composed of Radix et Rhizoma rhei, Radix scutellariae and Rhizoma coptidis *
    LI Peng-Yuan, LI-Li, LIANG Ri-xin, WANG Lan, LIU Yin, MA Yin-Lian, YU Ding-rong, YAO Jia-qi , XIAO Yong-Qing
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (3): 201-205.   DOI: 10.3969/j.issn.1006-2157.2015.03.012
    Abstract931)      PDF(pc) (1414KB)(863)       Save
    Objective To characterize the distribution of fingerprints of nine different compatibility formula (Formula 1~9) of Radix et Rhizoma rhei, Radix scutellariae and Rhizoma coptidis, three Chinese herbal medicines that comprise Sanhuang Xiexin decoction; to analysis the components of each formula, from which best effects of activating blood and resolving stasis were obtained. Methods High performance liquid chromatography (HPLC) was performed with Agilent C 18 column, acetonitrile and 1% formic acid gradient elution, detection wavelength at 280 nm, column temperature of 30℃. Results 24 characteristic peaks were included in each fingerprint of compatibility formulae, and 9 peaks were identified with chemical reference. Formula 7, whose proportion of baicalin, anthraquinone glycosides, anthraquinones aglycone and berberine hydrochloride was 2.8∶1.7∶1.6∶1.0 approximately, was determined to be optimal to activating blood and resolving stasis. Conclusion The methods established of fingerprints and component analysis are stable and reliable to be used for quality control of component compatibility formulae. Furthermore, components analysis of Formula 7, the optimal formula for activating blood and resolving stasis, is expected to explore the correlation between compatibility and effect.
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    Ancient TCM doctors’ views on treatment of vertigo since Han Dynasty:a data mining research
    LIU Xudong ,HE Qingyong, WU Haifang ,ZHONG Xiaoxue
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2016, 39 (11): 920-925.   DOI: 10.3969/j.issn.1006-2157.2016.11.007
    Abstract406)      PDF(pc) (1787KB)(861)       Save
    Objective To study 15 famous ancient TCM docotors’ prescribing herbal medicines for treatment of vertigo from Han Dynasty and the following periods, so as to provide basis for clinical treatment on vertigo as well as for researching and developing new medicines for treating vertigo. Methods A total of 128 traditional Chinese medicine prescriptions were collected and input into TCM Inheritance Auxiliary Platform Version 2.5. Using the method of improved mutual information entropy clustering, association rules, complex systems entropy clustering and unsupervised entropy hierarchical clustering, the pattern types, pairs of drugs ( two Chinese medicines used together), triangle drugs (three Chinese medicines used together) , association rules of drugs, evolution and extraction of combination of the core drugs, and prescriptions newfound were analyzed. Results The leading pattern of vertigo was hyperactivity of liver yang (frequency:30; rate:23.4%. Same below). The most commonly used herbal medicine was Fuling (49, 38.3%), and the most common pair of drugs was Zhigancao-Baizhu (29,22.7%), the most common triangle drugs was Zhigancao-Baizhu-Fuling (17,13.3%). The drugs combination with high correlation was Baizhu-Danggui→Zhigancao, with support of 10% and confidence of 0.937 5. Altogether 22 sets of triangle drugs were extracted, in which the core drugs were Renshen, Baizhu, Zhigancao, Chenpi, Fuling, Danggui. And 11 new prescriptions were available. Conclusion For research and development of new drugs on vertigo, we should focus on the pattern of hyperactivity of liver yang; prior compatibility rules are Baizhu, Danggui with Zhigancao and Chenpi, Baizhu with Renshen and Zhigancao, Renshen with Baizhu; when formulate a new prescrption, Fuling, Fushen, Zhigancao, Chenpi, Sangye, Juhua, Baizhu and Renshen deserve the priority.
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    On the origin, development and evolution of five-phase theory *
    YAN Long, HE Juan
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2016, 39 (9): 709-713.   DOI: 10.3969/j.issn.1006-2157.2016.09.001
    Abstract523)      PDF(pc) (1301KB)(852)       Save
    The theory of five phases is an essential component of philosophic theories in ancient China. However, the contemporary scholars have different views on the origin and the essence of this theory. Based on analysis of ancient literature,the following points of view are proposed. The ancient’s worship of the digit "five" was the basis of formation of five-phase. Formed in the Shang Dynasty late and early Zhou Dynasty,the concept of five phases came from the characteristics of five basic materials in life. Formed in the Western Zhou Dynasty, the viewpoint of restriction in the five phases was derived from the observations of the relationship between the five materials. In the Spring and Autumn Period, the restriction in the five phases was applied to political, military and other fields, and the uncertain restriction in the five phases was discovered.The concept of generation in the five phases which originated in the alternation of seasons was formed in the Warring States Period. It was the production of combination of four-season doctrine and five-material doctrine. Five-phase theory matured during the Warring States Period. The combination of generation and restriction in the five phases completed five-phase theory. Five-phase theory reached its peak in the Han Dynasty. The over-restriction and counter-restriction of five phases were proposed as the improvement of five-phase theory.
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    On relationship among skipping pulse, bound pulse, intermittent pulse and arrhythmia *
    Shen Wuxia, Wang Tianfang, Huo Yanming, Chen Xinran
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2018, 41 (6): 455-458.   DOI: 10.3969/j.issn.1006-2157.2018.06.003
    Abstract403)      PDF(pc) (1102KB)(839)       Save
    Skipping pulse, bound pulse and intermittent pulse are intermittent pulse conditions commonly seen in clinic, and they are closely related to arrhythmia in Western medicine. They are different pulses but they are generally referred as “intermittent pulses” without any distinguishment in clinical practice. This paper did an inductive analysis on ancient and modern literature about skipping pulse, bound pulse, intermittent pulse and arrhythmia. Skipping pulse is an irregular intermittent pulse with rapid pulse rate, and it can be seen in fast atrial fibrillation, irregular premature contractions, tachycardia and atrial flutter. Bound pulse is also an irregular intermittent pulse but with slower pulse rate, and it can be seen in sinus arrest, sinoatrial conduction block, atrioventricular block, irregular premature systole and escape beat. Intermittent pulse is a regular intermittent pulse with normal, rapid or slow pulse rate, and it can be seen in regular premature contraction, sinoatrial conduction block and atrioventricular block.
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    On statement of “if keeping health, Zusanli (ST36) frequently being given festering moxibustion” *
    MA Fangfang, PAN Shixia, LIN Yin, XI Xi, ZHANG Cong, LIAO Yan, WANG Jing, LI Bing, WANG Yichen, KE Xiuhui
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (5): 371-375.   DOI: 10.3969/j.issn.1006-2157.2017.05.004
    Abstract436)      PDF(pc) (1148KB)(826)       Save
    This article has analyzed the source and clinical significance of statement of “if keeping health, Zusanli (ST36) frequently being given moxibustion” based on philology and medical principles. The statement was recorded in Suosuilu (Trivial Details of Traditional Chinese Medicine) written in early Southern Song Dynasty, which was originally designed for preventing and curing wind diseases. The moxibustion on ST36 is to diffuse and unblock qi and blood of zang-fu organs, but is not to give festering moxibustion. If the statement is explained as repeated festering moxibustion, Yubaizhuang moxibution recorded in Beijiqianjinyaofang (Essential Prescriptions Worth a Thousand Gold for Emergencies) and Bao moxibution recorded in Zhenjiuzishengjing (Classic of Nourishing Life with Acupuncture and Moxibustion) used only in the condition of excessive yang deficiency will be misunderstood. Acupressure, frottage and foot bath can be selected in ST36 healthcare. Considering safety, some mild moxibustion therapies are recommended, such as suspended moxibustion and sandwiched moxibustion, in patients with obvious cold symptoms.
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    Pandemic risk factor analysis of COVID-19 and inspirations from its prevention and control
    Wang Yongyan, Wang Zhong, Bai Weiguo, Zhi Yingjie, Wang Yanping
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (8): 621-622.   DOI: 10.3969/j.issn.1006-2157.2020.08.001
    Abstract283)      PDF(pc) (1316KB)(816)       Save
    In order to promote effective prevention and control of the pestilence by traditional Chinese medicine (TCM), it’s of great significance to explore the main ways of the pestilence epidemic. The most weighted epidemic factor is the environmental degradation. Thus, the application of the Yunqi Theory emphasizing “harmony between man and nature” into the prevention and treatment of the pestilence in clinic would be the best way to gain the common consent of the effect and the decrease of the mortality, which might be a good opportunity to show TCM contribution to the health of the human. Based on the standardization of the operation procedures, it’s further suggested that extraction of key elements in patterns of the disease should be viewed as a breakthrough, combined with various technologies from the network, block data and big data of biological blockchain, thus ushering in the third stage of Chinese epidemiology.
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    Microscopic interpretation of TCM constitutional theory using intestinal microecology *
    HUANG Teng-jie, LI Ying-shuai, LUO Bin
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (5): 299-302.   DOI: 10.3969/j.issn.1006-2157.2015.05.002
    Abstract535)      PDF(pc) (1076KB)(800)       Save
    Modern microecology states that there are a lot of commensal bacteria on the surface and inside human body, and most of them reside in the human intestines. The microbiota, which colonize in the gut of the host, the host, and the environment, together constitute a unity of dynamic equilibrium. Intestinal microecology is mainly to explore the structure and function of gut microbiota in the bodies of healthy human beings, to discover the influence of the structural disorder of gut microbiota on human health, and to use its intervention to guide the host to live healthily. Human’s constitution in TCM theory is considered as an inherent characteristic, which is formed on the basis of the prenatal and postnatal development of human beings, and affects morphology, physiology and psychology. The human gut microbiota are involved in many physiological and pathological activities, and their changes could reflect the physiological and pathological state of the host, so the research method of using intestinal microecology to study TCM constitution could be of important significance in the individual treatment. The four basic principles and three scientific questions of TCM constitutional theory are strongly interrelated with the basic theory of intestinal microecology, and they could serve as mutual interpretation. Based on the study result of modern intestinal microecology, this paper attempts to combine TCM constitutional theory with intestinal microecology, and offers microscopic interpretation of the four basic principles and the three key scientific questions of TCM constitutional theory.
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    Clinical research on pattern characteristics features of cough with a cold feeling of sensation in the back: a clinical survey *
    LIN Bin, SHI Li-qing, MA Jian-ling, XI Ning, LUO Qiu, CHEN Yong-tai, WANG Qian
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (5): 356-360.   DOI: 10.3969/j.issn.1006-2157.2015.05.014
    Abstract572)      PDF(pc) (1099KB)(796)       Save
    Objective To observe clinical manifestations and TCM pattern features of cough with a cold sensation in the back (back cold), and to discuss and analyze its etiology and pathogenesis, in the hope of providing evidence for the treatment of cough. Methods Cases with cough as a chief complaint accompanied by a cold sensation in the back were selected. We analyzed the general information, underlying respiratory diseases, clinical characteristics of and relevant factors for cough with a cold sensation in the back, and summarized the onset characteristics, etiology, pathogenesis, and TCM patterns. Results Cough with a cold sensation in the back was common in clinical practice. Moreover, a cold sensation in the back was closely related to cough. Common pathological elements included dampness-heat, yang deficiency, retention of phlegm and morbid fluid, and pathogenic wind, etc. The pattern identification of TCM showed that spleen-stomach dampness-heat pattern accounted for 22.8% of all cases; dampness-heat pattern complicated with lung yang deficiency, 21.3%; lung yang deficiency, 17.3%; and yang deficiency of the lung and spleen, 12.7% respectively, etc. Conclusion A cold sensation in the back often accompanies cough, closely related to seasons, climate changes and etc. This symptom of varying degrees could be present in people of different ages and with different respiratory diseases. Most commonly-seen TCM patterns are retention of dampness-heat in the spleen and stomach and yang deficiency of the lung. Pathogenic dampness and heat may hinder qi movement. Moreover, the lung-spleen yang is deficient, and defensive yang fails to distribute. Consequently, the lung fails to spread and depurate. This is probably its main disease mechanism.
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    Exploration of Chinese medicine etiology of acute radiation injury: ionization toxin *
    WANG Lei, WANG An, HU Sumin
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (1): 27-30.   DOI: 10.3969/j.issn.1006-2157.2017.01.006
    Abstract383)      PDF(pc) (1166KB)(790)       Save
    As acute radiation injury began to burst in modern times, TCM standards of syndrome differentiation and treatment need to be explored. Acute radiation injury due to ionizing radiation is referred as "ionization toxin", a kind of toxin evil. Ionization toxin is characterized by rapid onset, serious injury and difficult to treat, which is different from heat toxin or light toxin. Meanwhile, there is distinction between ionization toxin and fire toxin in ways of evil attacked, trend of disease development and prognosis course. In a word, ionization toxin is new. By making a full understanding about the conception, pathogenic mechanism and features of the ionization ioxin,it will be beneficial for Chinese medicine to exert the advantages on the protection of acute radiation injury.
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    Comparison of two chromatographic methods for the determination of sugars in Danshen Injection (lyophilized powder) *
    LIU Jing, HAN Chun-xia, JIANG Yan, WANG Gang-li, LIN Rui-chao, DAI Zhong, MA Shuang-cheng
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (8): 556-560.   DOI: 10.3969/j.issn.1006-2157.2015.08.011
    Abstract363)      PDF(pc) (1209KB)(782)       Save
    Objective To compare two chromatographic Methods and then to select an accurate, convenient and rapid method for the determination of sugars in Danshen Injection (lyophilized powder). Methods Firstly, HPLC-ELSD method was applied on an Alltech Prevail TM Carbohydrate ES (4.6 mm × 250 mm, 5 μm) column, and acetonitrile-water (76∶24) was used as the mobile phase on an isocratic elution with ELSD as the detector. Apart from that, IC method was adopted on a CarboPac PA20 (150 mm × 3 mm, S/N 003654 ) anion exchange column with the CarboPac PA20 ( 50 × 3 mm, S/N 003405) column as the guard column, and sodium hydrate solution (7 mmol/L) was used as eluent with the pulsed amperometric detector. To sum up, HPLC-ELSD and IC Methods described above were applied to determine the sugars in Danshen Injection (lyophilized powder) respectively. Results Under the chromatographic conditions mentioned above, HPLC-ELSD method could simultaneously determine the contents of fructose and glucose. Linear relationship, precision, repeatability and recovery rate of the method were all qualified; IC method could simultaneously determine arabinose, galactose, glucose, sucrose, mannose as well as fructose, and the method proved to be accurate and reliable. The determination Results of fructose and glucose by both Methods were basically the same. Conclusion IC method seems to be a better choice to determine the monosaccharides and disaccharide in Danshen Injection (lyophilized powder).
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    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (3): 209-211.   DOI: 10.3969/j.issn.1006-2157.2015.03.014
    Abstract613)      PDF(pc) (1033KB)(782)       Save
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    Thinking process of TCM diagnosis and treatment under psychological logics model *
    SUN Chao ,XIE Qing-yu,MENG Qing-gang
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (3): 153-157.   DOI: 10.3969/j.issn.1006-2157.2015.03.002
    Abstract697)      PDF(pc) (1057KB)(761)       Save
    To explore TCM doctors’ mode and the process of logical reasoning of TCM diagnosis and treatment, regarded reasoning modes as research objects, by adopting methods of epistemic logic. The TCM doctors’ thinking process of diagnosis and treatment is a composite model of thinking, consisted of three parallel channels of abductive reasoning, analogic reasoning and inductive reasoning and one serial channel of deductive reasoning. The process can also be influenced by experiences, conviction, emotion and other psychological factors. The model which contains complicated recognition psychology factors will contribute to interpretation of the process of TCM diagnosis and treatment on the whole, to open a new way of understanding and to provide further reference for the research on the cognitive schema.
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    Collation methods of ancient books by the Office of Revising Medical Books in the Northern Song Dynasty *
    WANG Li-yuan, ZENG Feng
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (5): 306-309.   DOI: 10.3969/j.issn.1006-2157.2015.05.004
    Abstract489)      PDF(pc) (1145KB)(756)       Save
    By analyzing the differences between the two editions of Important Formulas Worth a Thousand Gold Pieces (Qian Jin Yao Fang) as well as other medical literature edited by Song scholars, this thesis has summed up most of the collation methods used by Song scholars to edit Traditional Chinese Medicine(TCM) ancient literature. Those methods include: rectification, addition of missed content, deletion of repeated content and the rearrangement as well as the reordering of content. It can be said that Song scholars outpaced the methods used by Han and Tang scholar and they put more emphasis on the accuracy and intactness of the content as well as the consistency of the form. The efforts of Song scholars have promoted the enrichment of Chinese medicine theories and accuracy of the Chinese medicine academic framework. Their work has a profound and extensive influence on the development of Chinese medicine theories.
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