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    Inheritance and development of spleen-stomach theory in Huangdi Neijing (Yellow Emperor’s Internal Classic) by Huang Yuanyu *
    Gao Zhili, He Juan
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2018, 41 (11): 890-893.   DOI: 10.3969/j.issn.1006-2157.2018.11.002
    Abstract562)      PDF(pc) (1052KB)(1385)       Save
    Spleen-stomach theory is an important academic thought in Huangdi Neijing ( Yellow Emperor’s Internal Classic). The idea of emphasizing earth was a concrete embodiment of Chinese philosophy in traditional Chinese medicine at that time. Later generations of doctors inherited and developed spleen-stomach theory in Huangdi Neijing, among them, Huang Yuanyu, a physician in the Qing Dynasty, was a particular representative. Huang’s theory of qi circumfluence and four images of earth pivot emphasizes the up-downs and rotation of qi in the middle earth, and stresses ascending of the left-side qi movement. He proposed that damp earth, cold water and wood depression were main pathogenesis of human diseases, which has important influence on later clinical practice.
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    Effect of glycyrrhizic acid on the activation and extracellular matrix secretion in renal interstitial fibroblast cells induced by transforming growth factor β1 *
    Di Liming, Zhang Lan, Shen Mengmeng, He Shuangshuang, Li Yu
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (5): 421-427.   DOI: 10.3969/j.issn.1006-2157.2021.05.006
    Abstract58)      PDF(pc) (1504KB)(112)       Save
    Objective To investigate the effect of glycyrrhizic acid (GA) on the expression of fibrosis-related factors in the renal interstitial fibroblastcells (NRK49F) of rats induced by transforming growth factor β1(TGF-β1). Methods NRK-49F cells were cultured in vitro.After 48 h of intervention with different concentrations of GA,Cell Counting Kit-8 was used to detect their effect on cell proliferation, so as to determine the concentration with no obvious effect on cell viability.The model was established by stimulating NRK-49F cells with 10 μg/L TGF-β1. Then different concentrations of GA were used for intervention. The expression of α-SMA and type 1 collagen (COL1) was detected with immunofluorescence method. The mRNA and protein expression of fibrosis-related factors of α-SMA,COL1, COL3 was detected with RT-PCR and WB methods, so as to evaluate the effect of GA on the activation of fibroblasts and the secretion of extracellular matrix. Results CCK-8 results showed that within the concentration range of 100~600 μmol/L, GA had no effect on the activity of NRK-49F cells.According to immunofluorescence results, the addition of GA intervention inhibited the expression of α-SMA and the secretion of COL1, with the increase of GA concentration,the inhibitory effect being enhanced. According to Western Blot results, GA intervention could down-regulate the expression of α-SMA, COL1 and COL3 compared with the model group; the expression level of COL1 protein in the GA 150 μmol/L group was reduced ( P<0.01), and the level of COL1 and COL3 in the GA 200 μmol/L group was reduced ( P<0.01). RT-PCR results showed that GA intervention could down-regulate the expression of α-SMA, COL1 and COL3 compared with the model group; among them, the mRNA expression level of COL1 in the GA 150 μmol/L group was reduced ( P<0.01), and the expression of COL1 and COL3 in the GA 200 μmol/L group was reduced ( P<0.01). Conclusion GA seems to inhibit the mRNA and protein expression of α-SMA, COL1 and COL3 in NRK-49F cells induced by TGF-β1, but its mechanism still needs to be further explored.
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    Brief account of Zhang Zhongjing’s medical origin *
    Pan Zhongyi, Fu Yanling, Song Jia, Ni Shenglou
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2018, 41 (11): 894-899.   DOI: 10.3969/j.issn.1006-2157.2018.11.003
    Abstract497)      PDF(pc) (1123KB)(808)       Save
    Zhang Zhongjing medicine has an extraordinary position and influence in the academic development history of traditional Chinese medicine (TCM). Those who have studied TCM since ancient times have absorbed nutrient from it. To study Zhongjing medicine, we should first understand its origin and development. In this paper, we comb up this issue from the following three aspects including the origin of Zhongjing medicine, the emergence of Zhongjing medicine, and the branch of Zhongjing medicine. We believe that the origin of Zhongjing medicine can be dated back to Sanshi Medicine in ancient times and Four Medical Schools in the Spring and Autumn Warring States period, the emergence of Zhongjing medicine is reflected as integration of medical classics and classical formulas and coherence of every section of TCM pattern differentiation and treatment, and the branch of Zhongjing medicine is mainly manifested as continuous development of Shanghan schools during 1 800 years, its important influence on other medical branches and schools, as well as the spread and changes abroad.
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    Connotation of “extreme yin being related to earth qi” in Suwen *
    Wang Mengqi, He Juan
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2019, 42 (8): 629-632.   DOI: 10.3969/j.issn.1006-2157.2019.08.003
    Abstract870)      PDF(pc) (1139KB)(438)       Save
    Suwen: Liujie Zangxiang Lun (Plain Conversation: Discussion on Six-Plus-Six System and the Manifestations of Organs) is one of important chapters on the theory of visceral manifestations in Huangdi Neijing (Yellow Emperor’s Internal Classic). On the understandings of the passage of “spleen, stomach, large intestine, small intestine, triple energizers, bladder… are extreme yin and they are related to earth qi”, the physicians in successive dynasties had great difference. The paper proposes, after analyzing the problems existing in several common viewpoints on the passage and combining the application of quartered yin-yang model and writing mode in the chapter, that the extreme yin can be regarded as a compromise saying by the author who tried to explain the relationship between four seasons and five zang-organs, and “extreme yin being related to earth qi” can be understand as extreme yin being related to qi of water and food. The paper also indicates that spleen and other zang-organs interact to each other in physical or pathological conditions. So it is a summarization on their functions of water-food conversion to name spleen and other zang-organs as extreme yin, which has clinical significance.
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    On significance of ancient astronomical coordinate systems for research into doctrine of five circuit phases and six atmospheric influences *
    Meng Qingyan, Zhang Qicheng, Zhang Qingxiang, Liu Yuanyuan
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2019, 42 (12): 983-987.   DOI: 10.3969/j.issn.1006-2157.2019.12.003
    Abstract437)      PDF(pc) (2006KB)(403)       Save
    As an important part of TCM theory, the doctrine of the five circuit phases and six atmospheric influences involves the pattern of changes in nature based on human’s observation and life experience.The doctrine emerged when astronomy in ancient China had reached a high level of precision.Thus, this paper analyzes the characteristics of three ancient astronomical coordinate systems,which may provide some reference for current study of the doctrine.It probes into the doctrine of the five circuit phases and six atmospheric influences and corrects some mistakes in the present research on the doctrine by analyzing it in the specific context where it emerged and developed. It also deepens the connotation of the doctrine by revealing the major, essential and inevitable factors in its formation, which provides reference for the learning and theoretical study of the doctrine.
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    Evaluating the effectiveness of ring management on patients with chronic obstructive pulmonary disease: a study in tertiary hospital, community health service stations, family *
    YAO Xiaoqin, FENG Cuiling, XUE Guangwei, QI Ying, Zhang Xiaoya, Wang Yanning, Ma Jia, Cai Wei, Liu Hongxia
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2016, 39 (4): 335-340.   DOI: 10.3969/j.issn.1006-2157.2016.04.013
    Abstract424)      PDF(pc) (1099KB)(509)       Save
    Objective To evaluate the effectiveness of ring management – tertiary hospital, community health service stations and family, on patients with chronic obstructive pulmonary disease (COPD). Methods Eligible patients were randomly divided into management group ( n=107) and control group ( n=103). All the patients were treated with the routine clinical practice, besides, systematic intervention for those in the management in the ways of health education, exercise management and medication management, who were managed by using COPD e-files. Furthermore, the patients in the management group were subdivided into Ba Duan Jin group and other exercises group according to the way of physical exercises, or into inhalation group and non-inhalation group according to the Western medication. COPD Assessment Test (CAT), the modified Medical Research Council (mMRC) Dyspnea Scale, number of acute exacerbation and lung function were analyzed before, six months post- and twelve months post- ring management. Results After 12 months of ring management, CAT score of patients in the management group decreased 4.69, mMRC scale decreased 0.52, the number of acute exacerbation less than twice increased to 75.7%, which were superior to that of control group( P<0.05). Increasing score of CAT in Ba Duan Jin subgroup was much more than that in other exercise subgroup( P<0.05). Increasing of FEV1% Pred in inhalation subgroup was more than that in non-inhalation subgroup( P<0.05). Score of CAT and number of acute exacerbation in the management group both decreased significantly compared with those in the control group( P<0.05). Conclusion Ring management model for COPD which can alleviate the symptoms of patients with stable COPD, improve the life quality and reduce the risk of exacerbation, is more comprehensive than medication management.
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    Overview of the traditional elements of Chinese scientific and technological civilization on elderly brain health
    Wang Yongyan, Wang Zixu, Wang Lei, Bai Weiguo
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (7): 581-584.   DOI: 10.3969/j.issn.1006-2157.2021.07.001
    Abstract136)      PDF(pc) (695KB)(83)       Save
    In this century, the emerging Law of Conservation of Information has a great influence on the evolution of scientific and technological civilization, which enlightens us to view scientific and technological civilization from the historical perspective. By tracing the origin of the research on brain health of the elderly and reviewing the elements of traditional civilization, this paper explains the cognition, understanding and interpretation of brain and brain health in Chinese traditional culture, which embodies the great wisdom of Chinese people. It advocates that the maintenance of brain health relies on to maintaining peaceful mind through sincerity and respect, and conforming to natural laws.The elderly should understand the natural law of birth, ageing, sickness and death and treating disease before its onset, adjust the balance of body and mind, and pursuespiritual thinking. It is clarified that early intervention of cognitive disorders is the key to the prevention and treatment of senile dementia, where traditional Chinese medicine can play a unique advantageous role, and the key to preventing and treating dementia is to delay the plateau period. The elderly with early mild cognitive impairment need to purify their mind through their own awareness of the living state, to respect sincerity and goodness,while cooperating with empathetic treatment by the medical staff and comfort of their families, so as to achieve the purpose of regulating health care, delaying the plateau period and preventing senile dermentia.
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    Analysis of three formulas against heart-yang deficiency based on syndrome differentiation in Treatise on Cold-Induced Diseases *
    ZHENG Fengjie
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2016, 39 (12): 973-977.   DOI: 10.3969/j.issn.1006-2157.2016.12.001
    Abstract702)      PDF(pc) (1295KB)(792)       Save
    Heart-yang deficiency syndrome, due to heart-yang deficiency, weak beating and internally exuberant yin cold, is characterized by palpitation or severe palpitations, stuffiness in the chest, lacking in strength, aversion to cold and cold limbs, pale complexion, or even critical signs triggered by syndrome of collapse of heart-yang. Heart yang collapse syndrome can be seen in sever conditions. Guizhi Gancao Tang, Guizhi Gancao Longgu Muli Tang and Guizhi Qu Shaoyao Jia Shuqi Muli Longgu Jiuni Tang, directed at hear-yang deficiency syndrome recorded in Treatise on Cold-Induced Diseases (Shang Han Lun) written by ZHANG Zhongjing, were referred to apply on mild, moderate and severe conditions of heart-yang deficiency. However, based on the analysis of the features of signs and syndromes of the three formulas against, this article puts forward that their indications are all emergency and intensive. And the difference among them are that Guizhi Gancao Tang focuses on tonifying heart to unblock yang, as well as warming the nutrient to nourish blood, resolving qi to move water, calming surging and directing counterflow downward, Guizhi Gancao Longgu Muli Tang emphasizes in subduing and astringing, and Guizhi Qu Shaoyao Jia Shuqi Muli Longgu Jiuni Tang can both treat unreleased of exterior pathogen and internally oppressed phlegm-heat.
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    Identifying the main pattern as the key to treating different diseases with the same method *
    WANG Fangfang, CHEN Jiaxu, HOU Yajing, MA Qingyu, LIU Yueyun, LI Xiaojuan
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (12): 978-981.   DOI: 10.3969/j.issn.1006-2157.2017.12.002
    Abstract454)      PDF(pc) (1254KB)(361)       Save
    Treating different diseases with the same method is an exemplification of the principle of treatment based on pattern differentiation in traditional Chinese medicine (TCM). Different diseases that develop to the same stage showing a similar pattern, or several concomitant disorders showing the shared pattern (main pattern), can be treated with the same method. TCM mainly focuses on the difference among patterns in the treatment of diseases, and the essence of treating different diseases with the same method is to identify the main pattern among the clustered symptoms and use them as the evidence to support the choice of treatment and prescription. In this paper, the concept of pattern and treating different diseases with the same method, and the relationship between them are explained. Priority is given to grasping the main pattern in treating different diseases with the same method. At the same time, relevant examples are listed in order to help understand how this method can be used in clinical diagnosis and treatment.
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    Interpreting pattern differentiation and treatment based on qi-circuit theory and philosophy of traditional Chinese culture: reading notes of Zhizhenyao Dalun in Suwen
    Wang Yongyan, Gao Ying, Zhang Yunling
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (8): 677-681.   DOI: 10.3969/j.issn.1006-2157.2021.08.001
    Abstract47)      PDF(pc) (794KB)(38)       Save
    Philosophy of traditional Chinese culture could be observed through the whole process of pattern differentiation and treatment in traditional Chinese medicine(TCM). First of all, Zhenggang Mingdao is the theoretical foundation for the integration of traditional Chinese culture into TCM pattern differentiation and treatment. In the Chapter of Zhizhenyao Dalun (Essentials on Disease and Therapy)in Suwen (The Yellow Emperor's Inner Classic: Basic Questions), qi-circuit theory is associated with disease; patterns and medicinal properties by Xiang image thinking (analogy) to interpret the principles of pattern differentiation and treatment.Secondly, the Dacheng (dialectical) wisdom is the vitality of adhering to and innovation of national medical culture. Based on the symbol system of yin-yang and Taiji, Zhizhen yao Dalun discusses the treatment of patterns and conditions caused by hyperactive state of any six qi or counter-restriction of pathogenic qi, which clarifies the overall dynamic process of TCM pattern differentiation and treatment.In addition, the adhering to and innovation of the national medical culture is carried out on the basis of inheritance. With the traditional Chinese culture and philosophy of analogism and generalization,we have proprosed the core pathogenesis of “toxin damaging brain collaterals”in stroke and summarized the key pattern elements based on the pathogenesis of six qi in Zhizhenyao Dalun, which would further enrich and improve the TCM pattern differentiation and treatment of stroke.As an important part of traditional Chinese culture and philosophy, the system of pattern differentiation and treatment of TCM are formed by doctors in past dynasties under the guidence of ancient philosophy. In the new era of digital civilization, it is our responsibility to promote the original thinking of TCM, build a unified medicine with Chinese characteristics and make new contributions to the great health of human beings by learning and practicing the principles of traditional Chinese culture and philosophy.
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    Study on eight trigrams- zangfu corresponding system based on image thinking of I-ching *
    Li Honghai, Han Qi, Ma Yuexiang
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (7): 585-590.   DOI: 10.3969/j.issn.1006-2157.2021.07.002
    Abstract145)      PDF(pc) (778KB)(606)       Save
    Eight trigrams- zangfu system has been used by many TCM doctors since ancient times. It plays a unique advantageous role in the interpretation of visceral manifestation and pathology. However, there still exist disputes and incompleteness in its specific corresponding relations. For example, Luo Dingchang, a doctor in the Qing Dynasty, thought that lung corresponds to Qian hexagram. Sun Yikui in the Ming Dynasty, however, held that Dui is the corresponding hexagram.Meanwhile, Zheng Qin'an in the Qing Dynasty, mainly discussed the heart and kidney from the two hexagrams of Li and Kan. As a result, the theory of eight trigrams- zangfu has not formed a unified and systematic corresponding system. Therefore, our team combined literature review and theoretical discussion in studying the relevant contents of I-Ching ( The Book of Changes in Zhou Dynasty), the TCM- Zhouyi theory, and the basic theory of TCM by using the image-number thinking in I-Ching. Based on the acquired eight trigrams, diction, shape, image and nature related to the physiological and functional characteristics of each viscera, we concluded that the correspondence of eight trigrams- zangfu system is as follows by using the thinking methods of image classification and image-number relation: Zhen corresponds to liver, gallbladder; Xun, liver; Li, heart, small intestine, pericardium; Kun, spleen, small intestine, bladder,triple energizer; Dui, lung, large intestine; Qian, lung; Kan, kidney, bladder,triple energizer; Gen, spleen, stomach, large intestine, gallbladder. And their corresponding relations are refined to the specific functions of zang-fu organs. It is hoped that the analysis and summary of the eight trigrams- zangfu corresponding system will be helpful to the development and research, and inheritance of TCM- Zhouyi theory and visceral manifestation theory, which can provide theoretical reference for clinical practice.
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    Administrative features of Chinese medicinals in treatment of diabetic macular edema *
    Hu Yuanchun, Jie Chuanhong, Wu Zhengzheng, Cai Wenjing, Wang Jianwei
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2018, 41 (5): 434-440.   DOI: 10.3969/j.issn.1006-2157.2018.05.014
    Abstract464)      PDF(pc) (1534KB)(429)       Save
    Objective To analyze the law of medicinals and discuss rules of clinical administration of Chinese medicinals and features of pattern differentiation and treatment in treatment of diabetic macular edema (DME). Methods The literature using TCM decoctions for treating DEM published at home and abroad were collected, analyzed and studied by applying modern computer data mining technology The core medicinals, core couplet medicinals and core medicinal combinations were analyzed, and the presicriptvons law was explored. Results A total of 54 articles were included in this study involving 99 kinds of medicinals with a total frequency of 540 counts. The top ten frequent single medicinals were Fuling (Indian Bread, Poria), Zexie (Oriental Waterplantain Rhizome, Rhizoma Alismatis), Huangqi (Milkvetch Root, Radix Astragali seu Hedysari), Danggui (Chinese Angelica, Radix Angelicae Sinensis), Chuanxiong (Sichuan Lovage Rhizome, Rhizoma Ligustici Chuanxiong), Zhuling (Chuling, Polyporus), Shengdihuang (Unprocessed Rehmannia Root, Radix Rehmanniae Recens), Baizhu (White Atractylodes Rhizome, Rhizoma Atractylodis Macrocephalae), Danshen (Salvia Root, Radix Salviae Miltiorrhizae), and Cheqianzi (Plantain Seed, Semen Plantaginis). There were 19 types of TCM patterns, which were divided into 3 categories: phlegm-stasis obstruction, spleen deficiency and water retention, and qi-blood and yin-yang deficiency. The top four couplet medicinals according to association rules were Fuling-Huangqi, Fuling-Zexie, Chuanxiong-Danggui, Fuling-Danggui. The top three-medicinal combinations according to association rules were Fuling-Chuanxiong-Danggui, Zexie-Danggui-Fuling, and Fuling-Zexie-Huangqi. The top three four-medicinal combinations according to association rules were Zexie-Chuanxiong-Danggui-Fuling, Chuanxiong-Danggui+Huangqi+Fuling, and Zexie-Danggui-Huangqi-Fuling. Conclusion DME was treated mainly with medicinals with effects of tonifying qi and inducing dieresis, and with medicinals with effects of activating blood and enriching blood to supplement. The TCM pathogenesis of DME is qi-blood and yin-yang deficiency leading to internal water retention, binding of phlegm-stasis and obstruction of ocular collaterals over the time.
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    Simultaneous determination of 7 coumarin constituents in Lyophilized Powder of Zhiqiao Houpo Tang by using HPLC-MS/MS *
    Xu Jianjun, Ren Ping, Liu Yalin, Yan Han, Chen Ken, Shi Shaoqi, Huang Xi
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2018, 41 (7): 585-592.   DOI: 10.3969/j.issn.1006-2157.2018.07.010
    Abstract335)      PDF(pc) (2068KB)(204)       Save
    Objective To establish a method for quantitative determination of 7 coumarin constituents, including isoimperatorin, bergapten, xanthotoxol, auraptene, 6′,7′- dihydroxybergamottin, bergamottin, and bergaptol in Lyophilized Powder of Zhiqiao Houpo Tang (Lyophilized Powder of Fructus-aurantii Magnolia-bark Decoction, LPFM) by using high performance liquid chromatography-mass spectrometry-tandem mass spectrometry (HPLC-MS/MS). Methods HPLC-MS/MS procedure was performed on the chromatographic column of Waters BEH C 18 (100 mm×2.1 mm, 1.7 μm) at 35 ℃. The mobile phase was acetonitrile (A)-0.1% formic acid water (B) in gradient elution, flow velocity was 0.25 mL/min and sample size was 10 μL. The mass spectrometry was operated with an electrospray ion (ESI) source for detecting positive ion mode. The mode of multi-reaction monitoring (MRM) was applied for quantitative determination. Results In 7 coumarin constituents, isoimperatorin showed a good linear relationship at a range from 1.01 μg/L to 101.2 μg/L ( r=0.999 6), and average recovery was 98.42% (RSD=1.88%). Bergapten showed a good linear relationship at a range from 5.25 μg/L to 525.0 μg/L ( r=0.999 8), and average recovery was 99.92% (RSD=1.30%). Xanthotoxol showed a good linear relationship at a range from 5.06 μg/L to 506.4 ng/mL ( r=0.999 6), and average recovery was 100.40% (RSD=1.76%). Auraptene showed a good linear relationship at a range from 4.96 μg/L to 496.0 μg/L ( r=0.999 7), and average recovery was 98.65% (RSD=1.80%). 6′,7′-Dihydroxybergamottin showed a good linear relationship at a range from 4.98 μg/L to 497.8 μg/L ( r=0.999 9), and average recovery was 101.16% (RSD=1.36%). Bergamottin showed a good linear relationship at a range from 0.99 μg/L to 98.6 μg/L ( r=0.999 6), and average recovery was 102.05% (RSD=1.65%). Bergaptol showed a good linear relationship at a range from 5.05 μg/L to 505.0 μg/L ( r=0.999 8), and average recovery was 100.73% (RSD=1.71%). Conclusion The method is quick, sensitive and accurate, which can be used for the quantitative determination of 7 coumarin constituents, including isoimperatorin, bergapten, xanthotoxol, auraptene, 6′,7′-dihydroxybergamottin, bergamottin, and bergaptol in LPFM.
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    A differentiation and analysis on connotation of disease-syndrome in Chinese medicine *
    SHEN Yifan, GAO Xue, XIAO Yonghua, ZHAO Jinxi, ZHU Li, WANG Jidong, SUN Huiyi
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (3): 181-184.   DOI: 10.3969/j.issn.1006-2157.2017.03.001
    Abstract548)      PDF(pc) (1208KB)(610)       Save
    Disease-syndrome is a frequently used term in clinical Chinese medicine. Disease-syndromes are body’s abnormal states affected by pathogenic factors with the same basic pathology, which are classified under the guidance of traditional Chinese medicine theory. Basic pathology is essential for the classification of disease-syndromes. It is the internal stable connection among all elements in disease-syndrome, and reflects and runs through the whole progress of disease-syndrome. In addition, basic pathology is also the internal basis used for determining the main symptoms of disease-syndromes and the laws for diagnosis and treatment in Chinese medicine. The implication of disease-syndrome is different from disease, syndrome and symptom. To properly understand the implication of disease-syndrome has a contribution to summarizing the previous clinical experience and guiding the clinical practice.
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    Effects of acupuncture on embryo quality in superovulating mice *
    ZHANG Yuanyuan, DING Deguang, ZHU Shuxiu
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2016, 39 (2): 169-172.   DOI: 10.3969/j.issn.1006-2157.2016.02.016
    Abstract376)      PDF(pc) (1162KB)(507)       Save
    Objective To explore effects of electroacupuncture on embryo quality in superovulating mice. Methods 60 female mice were randomly divided into natural group, negative control group, superovulating group and electroacupuncture group. Acupuncture group was treated with electroacupuncture on Sanyinjiao(SP6), Guanyuan(RN3) and Zhongji(RN4). Embryonic quality was evaluated based on the embryonic development status and blastula evaluation system. Results Superovulating group presented with the most number of embryos. High-quality embryo rate was relatively low. Moreover, the rate of Grade 3~6 blastocyst was the lowest in superovulating group. Compared with superovulating group, blastocyst rate in the electroacupuncture group was not significantly different ( P>0.05). However, rates of high-quality blastocyst and Grade 3~6 blastocyst were higher than the superovulating group with statistical significance ( P<0.05). Conclusion Acupuncture can improve embryo quality in superovulating mice and possibly improve implantation rate.
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    Self-isomorphic ideology of human body in Huangdi Neijing *
    LIAN Yi, HE Juan
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (4): 276-280.   DOI: 10.3969/j.issn.1006-2157.2017.04.003
    Abstract453)      PDF(pc) (1145KB)(464)       Save
    Isomorphic thinking is widely represented in Traditional Chinese Medical theory, which is primarily exemplified by Huangdi Neijing(Huangdi’s Internal Classic). The abstract theory that supports this type of idea interprets the correlation among categories with similarity instead of certainty, and tends to describe a similar logic of structure. This article selects theories about human body’s similar structure among physiological systems in Huangdi Neijing as examples to introduce the features and applications of this thinking. It shows a self-isomorphic conception in the anatomy of Traditional Chinese Medicine. There exists some logical similarity among categories as Zang and Fu organs, five Zang organs and body, meridians as well as five sensory organs. This association can be sorted by using Five-Element theory. Each element shares typical features of its own classification. Association among the various parts of human body can be identified and used in diagnosis and treatment. It enables the use of multi-modes in isomorphic comparison among categories as multi-dimension reference. Untypical elements also needs to be analyzed and rectified independently, which is the premise of this thinking.
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    TCM constitutions and depression-anxiety status in crew of high-speed rail trains of Beijing Railways: a survey and a correlation study *
    Jiang Min, Ding Jinfang, Song Qingkun, Wu Xin
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2018, 41 (3): 248-252.   DOI: 10.3969/j.issn.1006-2157.2018.03.012
    Abstract383)      PDF(pc) (1192KB)(284)       Save
    Objective To survey TCM constitutions in crew of high-speed rail trains of Beijing Railways, and analyze the correlation between different constitutions and depression-anxiety status. Methods TCM constitutions and depression-anxiety status were surveyed through cluster sampling and questionnaire by using Zung self-rating depressive scale (Zung’s SDS) and Zung self-rating anxiety scale (Zung’s SAS) in crew of high-speed rail trains of Beijing Railways. The characteristics of TCM constitutions and correlation between TCM constitutions and depression-anxiety status were analyzed. Results The crew with yang deficiency constitution (including those with accompanied yang deficiency constitution) accounted for 47.0%, those with qi deficiency constitution (including those with accompanied qi deficiency constitution), 42.3%, with qi depression constitution (including those with accompanied qi depression constitution), 40.9%, with yin deficiency constitution (including those with accompanied yin deficiency constitution), 31.7%, with phlegm-dampness constitution (including those with accompanied phlegm-dampness constitution), 30.6%, with blood stasis constitution (including those with accompanied blood stasis constitution), 28.1%, with damp-heat constitution (including those with accompanied damp-heat constitution), 14.6%, with specific constitution (including those with accompanied specific constitution), 12.1%, and with normal constitution, 3.9%. All constitutional types were significantly correlated to depression-anxiety status ( P<0.05). The incidence of anxiety was lower in crew with normal constitution, and increased significantly in those with 8 deflective constitutions including qi deficiency, yang deficiency, yin deficiency, phlegm-dampness, damp-heat, blood stasis, qi depression and specific constitutions ( P<0.005 or P<0.001). The risk of depression in those with qi deficiency constitution was 2 times as much as in those without qi deficiency constitution (OR=2.03, 95%CI: 1.05-3.94). Qi deficiency constitution was significantly correlated to anxiety (OR=1.95, 95%CI: 1.07-3.56). Conclusion The yang deficiency constitution (including those with accompanied yang deficiency constitution) and qi deficiency constitution (including those with accompanied qi deficiency constitution) are most common constitutions in crew of high-speed rail trains of Beijing Railways. The adjustment of these two constitutions may be a thinking train and method for controlling depression-anxiety status in crew of high-speed rail trains of Beijing Railways, which can be an important content in occupational health guardianship.
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    Effect of therapeutic principle of “cultivating soil to restrict water”on ATP content and mitochondrial apoptosis pathway in rats with uremic cardiomyopathy *
    Zheng Minlin, San Qin, Liu Guang, Xu Rongrong
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (8): 714-721.   DOI: 10.3969/j.issn.1006-2157.2021.08.007
    Abstract20)      PDF(pc) (1507KB)(33)       Save
    Objective To study the mechanism of Yishen Jiangzhuo(kidney-tonifying turbidity-downsending) Granule(YSJZG), a TCM formula under the therapeutic principle of “cultivating soil to restrict water”, in protecting the heart of rats with uremic cardiomyopathy. Methods 5/6 nephrectomy rat models were randomly divided into sham operation group, model group, emodin group and low-, mid- and high-dose YSJZG group ( n=10). Rats in each drug group were given corresponding drugs by gavage once a day for 2 months. Rats in the sham operation group and model group were given the same amount of distilled water by gavage. After the treatment, the levels of BUN, Scr, CK-MB and LDH in the blood of abdominal aorta were detected; the pathological changes of heart of rats were observed by hematoxylin eosin (HE) staining; the content of adenosine triphosphate (ATP) in rat heart tissue was detected by chemiluminescence; the content of ATP in rat heart tissue was detected by Tunel Western blotting to detect myocardial apoptosis in heart tissue; and the protein expression levels of Cytochrome C, Caspase-3 and Caspase-9 was detected by Tunel. Results Compared with the model group, YSJZG alleviated the pathological changes of heart in uremic cardiomyopathy rats, improved the levels of BUN, Scr, CK-MB and LDH ( P<0.05), and increased the content of ATP in heart tissue in uremic cardiomyopathy rats ( P<0.05); besides, the expression of Cytochrome C, Caspase-3 and Caspase-9 decreased significantly ( P<0.05). Conclusion The cardioprotective effect of YSJZG on uremic cardiomyopathy rats may be related to its inhibition of mitochondrial apoptosis pathway.
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    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2016, 39 (7): 614-616.   DOI: 10.3969/j.issn.1006-2157.2016.05.017
    Abstract311)      PDF(pc) (1125KB)(383)       Save
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    Origin and development of moxibustion
    GAO Zhiping
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (1): 16-19.   DOI: 10.3969/j.issn.1006-2157.2017.01.004
    Abstract514)      PDF(pc) (1223KB)(1342)       Save
    This paper puts forward the concept of “original moxa-moxibustion” from the perspective of natural cognition. Based on the ancient unique views on the traditional cultural traits of Nature, Asiatic wormwood, lives and diseases, original moxa-moxibustion was the perfect combination of mysterious phenomena with magical strength guided by ancient natural philosophy, and was shared with sorcery, medicine and Taoism. Then the use of fire accompanied by labor practice pushed the popularization of original moxa-moxibustion which transformed into moxa-moxibustion therapy of traditional Chinese medicine, after integrating with traditional medicines on human physiology, pathology and pharmacology, and learning from the technique of stone needles. Original moxa-moxibustion was earlier than moxibustion therapy, because use of fire was earlier than use of medicines. Development and innovation of moxibustion need deep understanding its origin and characteristics, as well as studying traditional culture and modern technology on thinking, techniques, Methods and tools.
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    How traditional Chinese medicine views the body and nurtures life with physical exercises *
    LI Youqiang
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (10): 817-824.   DOI: 10.3969/j.issn.1006-2157.2017.10.005
    Abstract485)      PDF(pc) (1269KB)(722)       Save
    Compared with the body views in traditional Confucius and Daoism, traditional Chinese medicine (TCM) has broken through the traditional concept of “body and mind” and “mind is greater than the body”, putting the biological body in the ontological position. TCM views the body from the following three aspects: anatomical body focusing on physiological structure; qi-movement body focusing on movement; and emotional body focusing on emotional status. The anatomical body view corresponds to “neither internal nor external cause” and is against risky physical activities. It advocates sport safety to avoid any potential risk of injury. The qi-movement body view corresponds to “external cause” and advocates physical activities in line with the solar terms rather than otherwise. Emotional body view corresponds to “internal cause” and advocates common mild physical activities. It is against emerging stimulant sports. Therefore Daoyin is considered as the optimal form of exercise for nurturing life. Although those intense stimulant sports are not advocated in TCM body view, there is still room for these types of physical activities to exist, as the logic of TCM body view is to harmonize and regulate all physical activities.
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    Regulation on autophagy with tanshinone Ⅱ A for anti-oxidative stress damage of endothelial cells through PI3K/Akt/mTOR pathway *
    CAO Huimin, SONG Nan, ZHANG Ni, YANG Guanlin, CHEN Wenna, ZHANG Zhe, JIA Lianqun
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (11): 933-939.   DOI: 10.3969/j.issn.1006-2157.2017.11.011
    Abstract328)      PDF(pc) (2429KB)(520)       Save
    Objective To investigate the protective and mechanism of tanshinone Ⅱ A (TSⅡ A) in oxidative stress damage of endothelial cells induced by oxidized low-density lipoprotein (ox-LDL) based on PI3K/Akt/mTOR autophagy pathway. Methods EA. hy926 cells were cultured in vitro, and then randomly divided into normal group, model group, ox-LDL+TSⅡ A group, ox-LDL+TSⅡ A+LY294002 group, TSⅡ A group and LY294002 group. The content of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) were detected by using chromatoptometry, autophagy status was observed by using FITC-LC3 fluorescence microscope and Naolive 3D Cell Explorer Real-time Microscopic Imaging System, and meanwhile, expressions of autophagy-related proteins and PI3K/Akt/mTOR pathway proteins were detected by using Western Blotting. Results Compared with normal group, MDA content increased, SOD activity decreased and content of LC3-I/LC3-II protein increased in model group ( P<0.01), and after TSⅡ A intervention, MDA content decreased, SOD activity increased and content of LC3-I/LC3-II protein increased (P<0.01). Compared with normal group, protein expressions of PI3K, p-Akt and p-mTOR decreased significantly in model group ( P<0.05 or P<0.01). Compared with model group, protein expressions of PI3K, p-Akt and p-mTOR decreased significantly after TSⅡ A intervention ( P<0.05 or P<0.01). Compared with ox-LDL+TSⅡ A group, content of LC3-I/LC3-II protein decreased and autophagy level decreased ( P<0.01) after applying LY294002, an inhibitor of PI3K. Conclusion Tanshinone Ⅱ A may improve autophagy through regulating PI3K/Akt/mTOR pathway to relieve the oxidative stress damage of EA. Hy926 cells and prevent atherosclerosis.
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    Understanding the “eight extraordinary meridians system” in the Case Records as a Guide to Clinical Practice based on the theory of “six compartments of yin and yang” *
    Chen Xu, Jia Bo
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2020, 43 (10): 825-829.   DOI: 10.3969/j.issn.1006-2157.2020.10.005
    Abstract193)      PDF(pc) (1168KB)(198)       Save
    The pattern identification of the eight extraordinary meridians reflected in the book titled Lin Zheng Zhi Nan Yi An (Case Records as a Guide to Clinical Practice) includes the theories of “six compartments of yin and yang”, “triple jiao” and “branch, root and center of six qi” in Huangdi Neijing, align with Ye Tianshi’s theory of “defense-qi-construction and blood” and “triple jiao”. The common route of Taichong meridians is from the bottom to the top, or from the root of Shaoyin through Yangming to the top of Guangming, crossing three jiao and three compartments, supplied with defense, qi, nutrient and blood by all the meridians. The essential qi is thus vaporized upwards to the brain. The defensive qi of all zang-organs in the triple jiao diverges into two pathways: one outside the vessels, or defensive qi goes out of triple jiao and flows into six fu organs; the other infusing into the vessels and converge at the extra meridians. The extra meridians are similar to lakes and rivers. They echo with the solitary organ of triple jiao. Interiorly, extra meridians unite the defense, qi, nutrient and blood, govern the three yin and three yang meridians to harmonize yin and yang, harmonize the essential qi and unite six qi; whereas exteriorly, triple jiao governs the defense, qi, fluids and humor, so as to balance heat and cold as well as yin and yang. When extra meridians and triple jiao are harmonious interiorly and exteriorly, yin-yang balance is achieved. By establishing the extra meridian system of Ye Tianshi, it can be used as reference to help us understand the physiology and pathology of traditional Chinese medicine, as well as predict, prevent, diagnosis and treatment of diseases.
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    TCM tumorigenicity in the perspective of holism *
    Fu Xi, Xiao Chong, Ren Yifeng, Zhu Jie, Zheng Chuan, Jin Zhao, Yan Ran, You Fengming
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (8): 688-693.   DOI: 10.3969/j.issn.1006-2157.2021.08.003
    Abstract34)      PDF(pc) (804KB)(32)       Save
    Tumor, as a living organism and a representation of different dimensions of structure, energy and function, is a highly unified tissue combining xing (form), qi and shen (vitality). Shen is the root for tumorigenesis, qi is the fundamental factor, and xing is the image of tumorigenesis. Shen, qi and xing interact with each other, thus forming tumorigenesis of TCM. It provides a comprehensive vision for the entirety regulation of tumor under the guidance of such a theory with a holistic view on how tumor is generated.This study further points out that such a new perspective should be employed in the formulation of tumor diagnosis and treatment strategies, the construction of a therapeutic effect evaluation system, the holistic study of its mechanism, the development of antitumor drugs and exploration of a tumor model. The aforementioned are all needed to be included in the new cognition of tumorigenesis of TCM. Importantly, focus should be shifted from the combination of structure and energy to the integration of energy, structure and function, and emphasis should be equally paid to the regulation of xing, qi and shen, instead of only emphasizing xing and qi.
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    Correlation between Kupperman scores and TCM constitutional types in menopausal women
    WANG Hong-bin, CUI Jian-mei, ZHAO Shu, SUN Na, ZHANG Ping, SHI Yun-ke
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2014, 37 (4): 277-279.   DOI: 10.3969/j.issn.1006-2157.2014.04.015
    Abstract545)            Save
    Objective To discuss the correlation between Kupperman scores and TCM constitutional types in menopausal women. Methods A TCM constitution questionnaire was used for investigating TCM constitutional types in 130 menopausal women and the results were analyzed. Results ①Age, BMI, menarche age, marriage age, primiparous age, pregnant times and puerperal times had no statistical significance in menopausal women with different Kupperman scores ( P>0.05). ②Kupperman scores were negatively correlated to score of normal constitution, and positively correlated to scores of other 8 types of abnormal constitution ( P<0.01). There was significant difference among menopausal women with the same constitutional types but different Kupperman scores ( P<0.01), and score of normal constitution decreased as menopausal symptoms exacerbated. ③The menopausal symptoms were mostly mild and medium in women with normal constitution, and severe in women with other abnormal constitutions. Conclusion Constitutional types is closely correlated to degree of menopausal symptoms, and differentiation of constitutional types will be helpful to prevention and treatment of menopause syndrome in clinic.
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    Correlation between structural shifts of gut microbiota and hyperuricemia in quails
    HUANG Sheng-nan, LIN Zhi-jian, ZHANG Bing, GENG Di, NIU Hong-juan, ZHU Chun-sheng, WANG Xue-jie, SUN Bo-yu
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (7): 452-456.   DOI: 10.3969/j.issn.1006-2157.2015.07.006
    Abstract955)      PDF(pc) (1356KB)(928)       Save
    Objective To explore the effect and potential mechanism of gut microbiota on the development of hyperuricemia(HUA). Methods Altogether 48 Difake male quails were randomly diveded into four groups ( n=12 each) according to body weight: normal group(N group), model group(M group), antibiotics and normal diet group(Ab+N group), and antibiotics and high-purine diet group(Ab+M group). Quails in N group and Ab+N group were fed with normal diet, and those of other two groups were fed with high-purine diet; at the same time, quails in N group and M groups drank clean tap water, and those of Ab+N group and Ab+M group drank water containing ampicillin (150 mg/L) and neomycin (75 mg/L) for consecutive 28 days. The microbiota structure of quail gut was determined by PCR-DGGE, while the concentration of endotoxin (LPS) in plasma and cecal content, serum uric acid (UA), xanthine oxidase (XO) activity in serum and liver were measured by automatic biochemical analyzer or multiscan spectrum. Results Compared with N group, the gut microbiota structure of M group changed, as well as the concentration of LPS in plasma and cecal contents, the activity of XO in serum and liver, and serum UA all increased significantly ( P<0.05 or P<0.01); however, the indicators mentioned above showed no significant differences in Ab+N group and Ab+M group ( P>0.05). Compared with M group, the concentration of LPS in plasma and cecal contents, the activity of XO in liver, and serum UA in Ab+N group and Ab+M group all decreased dramatically( P<0.05 or P<0.01). Conclusion High-purine diet induced structural shifts of gut microbiota and HUA in quails. The concentration of LPS, metabolite of gut microbial flora, is positively related to the activity of XO and serum concentration of UA. And the occurrence of hyperuricemia maybe is attributed to activation effect of LPS on XO activity.
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    Exploration of primordial qi in TCM *
    Li Zhihui, Wang Xiaoping
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2019, 42 (9): 709-712.   DOI: 10.3969/j.issn.1006-2157.2019.09.001
    Abstract594)      PDF(pc) (1265KB)(405)       Save
    The article puts forward that primordial qi refers to prenatal qi and original qi denotes both prenatal qi and postnatal qi. It expounds the connotation of the primordial qi in TCM and its relationship with the original qi. Firstly, the article argues that it is necessary to propose the concept of primordial qi in view of the ambiguity of the concept of the original qi. Secondly, it analyzes that primordial qi means the prenatal qi of the life gate and that it is the prenatal source, primordial driving force and the essence of healthy qi. Finally, it differentiates the primordial qi from the original qi in terms of their connotations, their prenatal and postnatal attributes, their yin and yang attributes, and treatments for their diseases.
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    The Number for the Great Expansion Method of Divination: Decoding nutrient-defense circulation in Huangdi Neijing *
    Xing Yurui
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2019, 42 (12): 977-982.   DOI: 10.3969/j.issn.1006-2157.2019.12.002
    Abstract430)      PDF(pc) (1186KB)(255)       Save
    Both the point that the nutrient qi and defense qi circulate within human body fifty times during one day-night cycle and the stipulation that the duration of one session of pulse-taking should be as long as fifty pulse beats in The Spiritual Pivot probably originated from the statement in The Book of Changes that the Number for the Great Expansion Method of Divination is fifty. This statement, which may derive from the Number for Heaven and Earth,provided the cosmological basis for the Number for the Great Expansion Method of Divination and exerted profound influence on calendar and mathematics in later ages. From the perspective of the correspondence between human and universe, the Number for the Great Expansion Method of Divination, as the basis for denominating the timing sequence of nature, becomes the number used to regulate life activities. Therefore, the fifty times of nutrient-defense circulation and the fifty pulse beats during pulse diagnosis are probably pre-determined by the Number for the Great Expansion Method of Divination, which is fifty. Through mathematical deduction, it is calculated that the length of the 28 meridians in human body is 16.2 zhang (about 170.7 feet), the distance qi travels per breath (one inhalation and one exhalation) 6 cun (about 7.559 inches), and the number of breaths during one day-night cycle 13,500. However, such calculation may inevitably cause some theoretical contradictions and those numbers disagree with reality since they are influenced by Chinese numerology.
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    Study of the relationship between membrane system and defense-qi-nutrient-blood pattern identification in traditional Chinese medicine *
    Jiang Xin, Gu Xiaohong, Liu Tiegang, Yu He, Yang Guannan
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2019, 42 (12): 973-976.   DOI: 10.3969/j.issn.1006-2157.2019.12.001
    Abstract480)      PDF(pc) (1172KB)(283)       Save
    Defense-qi-nutrient-blood pattern identification,initiated by Ye Tianshi, an expert of warm disease at the end of the Ming Dynasty,was a cornerstone of the theory of warm disease. Based on years of clinical experience, it is found that the membrane system and collateral system, which are extensively distributed in the human body, are the defense-qi-nutrient-bloodcarrier and channel, replenishing and nourishing the whole body and ensuring the defense-qi-nutrient-blood physiological functions. At the same time, the membrane system is also the place where warm pathogens attack, transmit and change.In addition, the struggle between healthy qi and pathogenic factors in the membrane system determines the location, depth, urgency and pathological changes of disease.Therefore, this article explores the relationship between the membrane system and defense-qi-nutrient-blood pattern identification in terms of their connotation, physiology, pathology and treatment to provide theoretical reference for clinical practice and scientific research.
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    Effect of Peiyuan Kang'ai Decoction in regulating autophagy of Lewis lung cancer through PI3K-AKT-mTOR pathway to inhibit tumor growth and metastasis *
    Si Hailong, Chen Yu, Gou Tao, Wang Caidong, Xiao Haijuan, Fang Yu, Wang Huiling
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (8): 722-728.   DOI: 10.3969/j.issn.1006-2157.2021.08.008
    Abstract26)      PDF(pc) (892KB)(30)       Save
    Objective To observe the inhibitory effect of Peiyuan Kang'ai (Healthy qi-supplementing Anti-cancer) Decoction(PYKA Decoction) on tumor growth and lung metastasis of Lewis lung cancer mice, and to explore the effect of PKKA Decoction on autophagy and PI3K-AKT-mTOR pathway. Methods Lewis lung cancer cells were inoculated subcutaneously in the right armpit of C57BL/6 mice to establish Lewis lung cancer bearing mice model. The tumor bearing mice were randomly divided into model group, cisplatin group, PYKA Decoction group and PYKA Decoction-cisplatin group. After the interventions of traditional Chinese medicine decoction by gavage and intraperitoneal injection of cisplatin, the quality of life of mice was observed; the lung metastasis was observed and the inhibition rate of lung metastasis was calculated; the tumor mass and tumor inhibition rate were calculated; the formation of autophagic vesicles was observed by transmission electron microscope; Western blot was used to observe the expression of autophagy factors LC3Ⅱ/ LC3Ⅰ, as well as the expression levels of PI3K/p-PI3K, AKT/p-AKT and mTOR/p-mTOR in tumor tissues. Results The quality of life of mice in the model group and cisplatin group was poor, and there were aggregation, hair shedding and slow reaction in mice; while the quality of life of mice in PYKA Decoction group and PYKA Decoction-cisplatin group was better. Compared with those of the model group,in PYKA Decoction group and PYKA Decoction-cisplatin group,lung metastasis was significantly inhibited ( P<0.05), and in the cisplatin group, there was a tendency to inhibit lung metastasis, but there was no statistical significance ( P>0.05). Compared with that of the model group, the growth rate of tumor was significantly inhibited in the PYKA Decoction group,PYKA Decoction-cisplatin group and cisplatin group ( P<0.05); specifically, the inhibition rate of tumor was higher in the cisplatin group than the PYKA Decoction group ( P<0.05), and significantly higher in the PYKA Decoction-cisplatin group, compared with that of PYKA Decoction group or cisplatin group.Compared with the model group, the number of autophagic vesicles increased significantly in cisplatin group, PYKA Decoction group and PYKA Decoction-cisplatin group, suggesting that autophagy was enhanced. Compared with PYKA Decoction group, the expression of LC3Ⅱ/ LC3Ⅰ was higher in the cisplatin group and PYKA Decoction-cisplatin group ( P<0.05), with that in the PYKA Decoction-cisplatin group being the highest( P<0.05). Compared with the model group, there was no significant difference in the expression of PI3K/AKT /mTOR in the tumor tissues of the treatment groups ( P>0.05).The expression levels of p-PI3K/p-AKT/p-mTOR in the tumor tissues of the treatment groups were significantly lower than that of the model group ( P<0.05); compared with that of the PYKA Decoction group, the expression of p-PI3K/p-AKT/p-mTOR in cisplatin group and PYKA Decoction-cisplatin group was lower ( P<0.05), with that in PYKA Decoction-cisplatin group being the lowest( P<0.05). Conclusion PYKA Decoction could potentially improve the quality of life of mice and inhibit tumor growth and metastasis. The mechanism may be related to the inhibition of PI3K-AKT-mTOR signaling pathway and enhancement of tumor autophagy.
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    Correlation analysis between pharmacokinetics of Kaixin San, Radix Polygalae and its monomer based on internal representations of sibiricose A5 and A6 in rats with acquired dysmnesia *
    BA Yinying, JIANG Yanyan, WU xia, SHI Renbing
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (10): 703-708.   DOI: 10.3969/j.issn.1006-2157.2015.10.013
    Abstract379)      PDF(pc) (2319KB)(513)       Save
    Objective To study anti-dementia effects of Kaixin San (Joyful Powder) and Radix Polygalae's based on pharmacokinetic characteristics of sibiricose A5, sibiricose A6, 3,6'-disinapoyl sucrose, and polygala xanthone III in rats with acquired dysmnesia model from three levels: monomer, medicinal and formula. Method Serum concentrations of sibiricose A5 and sibiricose A6 after oral administration in rat model were measured by using HPLC-PDA Pharmacokinetic data were obtained. Then different forms of sibiricose A5 and A6 were compared with correlation analysis (PK-DI) . Result Concentration-time curves showed that the pharmacokinetic profiles were similar in the absorption phase when Radix Polygalae extract and Kaixin San were orally administered. A bimodal pattern of sibiricose A5 and A6 in the serum profile was revealed. However, this phenomenon was not observed in the group of monomer. Radix Polygalae extracts and Kaixin San were similar in the measurements of AUC, and levels of monomer were decreased significantly ( P< 0.01). Compared to the oral administration of Radix Polygalae extract, Cmax-1 and Cmax-2 of Kaixin San were increased significantly ( P< 0.05).Conclution The results showed that the absorption of sibiricose A5 and A6 in rats was superior when Kaixin San was administered. This finding supports the rationale for using the Kaixin San combination in clinical use.
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    Effect of Zuogui Jiangtang Jieyu Formula on amino acid transporter expression in hippocampal astrocytes of diabetes mellitus rats with depression *
    XU Yalan,ZHAO Hongqing,DU Qing, YAN Hui,MENG Pan, WANG Yuhong
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2016, 39 (6): 470-475.   DOI: 10.3969/j.issn.1006-2157.2016.06.007
    Abstract353)      PDF(pc) (3140KB)(300)       Save
    Objective To investigate the effects of Zuogui Jiangtang Jieyu Formulation (ZGJTJYF) on the expression of excitatory amino acid transporter 3(EAAT 3) and vesicular glutamate transporter 2(VGLUT 2) in hippocampal astrocytes of diabetes mellitus rats with depression (DD). Methods DD rats were induced by intragastrical administration of high-fat diet, tail intravenous injection of streptozotocin (STZ) with 28 days’ chronic stress and were randomly divided into five groups—model group, positive drug group (metformin with fluoxetine), high-, middle-, and low- dose of ZGJTJYF (high-dose, mid-dose, and low-dose) group. Healthy SD rats were assigned into blank control group. After four consecutive weeks the cognition ability was measured using Morris water maze, and the expression of EAAT3 and VGLUT2 were detected by using immunohistochemical double labeling method. Results Compared with blank control group, escape latency of model group was significantly longer ( P<0.01), EAAT 3 expression decreased, VGLUT 2 expression increased remarkably (both P<0.05). Compared with model group, escape latency of positive drug group and in high-dose group decreased significantly( P<0.01),expression of EAAT3 in positive drug group and all ZGJTJYF groups increased( P<0.05), and VGLUT2 expression in positive drug group and high-dose group decreased significantly (P<0.05). Conclusion Zuogui Jiangtang Jieyu Formula can improve the disorder of EAAT3 expression and VGLUT2 expression in hippocampal astrocytes of diabetes mellitus rats with depression.
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    Textual research to identify the original plants for Kui and Dongkuizi *
    ZHOU Guanwu, QI Zhensheng, TIAN Jianfu, DI Guiying, WANG Tao, WU Chengliang, YANG Na
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (10): 828-832.   DOI: 10.3969/j.issn.1006-2157.2017.10.007
    Abstract375)      PDF(pc) (1249KB)(622)       Save
    This study aims to identify the original plants for Kui and Dongkuizi by reading and analyzing relevant historical literature. Misidentifications, misjudgments and false corrections by Japanese and Chinese experts as well as by modern and ancient scholars have been refuted and rectified based on comparing plant morphological characteristics, nomenclature basis, place of origin, growing environment, indications and therapeutic effects. The findings show that the ancient and modern records of the original plant for “Kui” as well as “Dongkuizi” from the family of Malvaceae is inaccurate. The original plant is creeping spinach (Basella alba, also known as Vine Spinach, Red Vine Spinach, Climbing Spinach) belonging to Basellaceae family.
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    Prediction of toxicity mechanism of Kunming shanhaitang based on network pharmacology and with molecular docking *
    Zhang Dan, Dong Yizhu, Lyu Jintao, Zhang Xiaomeng, Lin Zhijian, Zhang Bing
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2019, 42 (12): 1006-1015.   DOI: 10.3969/j.issn.1006-2157.2019.12.007
    Abstract627)      PDF(pc) (3667KB)(244)       Save
    Objective To explore the potential toxicity mechanism of Kunming shanhaitang(Tripterygium Hypoglaucum Toot, Radix Tripterygium Hypoglaucum) with Methods of network pharmacology and molecular docking. Methods Literature on Kunming shanhaitang was first comprehensively searched to identify and collect its active ingredients and adverse drug reactions (ADRs), respectively. Targets of the active ingredients were then predicted with TCMSP, Swiss, and STITCH databases. Moreover, targets of ADRs were gathered through CTD database. Next, the common genes shared by the above two types of targets were submitted to STRING to obtain protein-protein interaction. In addition, GO biological function process and KEGG pathway enrichment analysis were conducted on DAVID platform. Finally, molecular docking was carried out between characteristic ingredients of the herb and its key toxicity targets with systemsDock Web Site. Results A total of 21 ingredient candidates of Kunming shanhaitang involving 47 toxicity targets were identified by establishing toxic protein-protein interaction(PPI) network. PPI network enrichment analysis of the toxicity targets showed that such targets were probably closely associated with the p53 signaling pathway, PI3K-Akt signaling pathway and some other pathways. According to the Results of molecular docking, the majority of the active ingredients in the medicinal herb enjoyed good binding activities with the toxicity targets. Conclusion This research verified preliminarily the toxicity mechanism of Kunming shanhaitang, providing new ideas and Methods for further research on the toxicity mechanism of ADRs of Chinese medicinal herbs with toxicity.
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    Thoughts and methods in treatment of cancer pain based on theory of “all pain, itchiness or sore disorders pertaining to the heart” *
    Ni Baoyi, Zhu Xiaoyu, Li Jie
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2021, 44 (8): 764-768.   DOI: 10.3969/j.issn.1006-2157.2021.08.013
    Abstract40)      PDF(pc) (785KB)(28)       Save
    Cancer pain is one of the main botherings of cancer patients in the late stage. Although the “three-step” cancer pain treatment principle in western medicine has obvious effects on most patients, there are still defects such as great toxic and side effects. In TCM, cancer pain is classified as a “pain pattern”. According to the 19 pathogenesis explored in Huang Di Nei Jing (The Yellow Emperor's Inner Classic): Basic Questions,“all pain, itchiness or sore disorders pertain to the heart”, and modern studies have gradually found that cancer pain is related to the function of the “heart”.Therefore, based on the theory of “all pain, itchiness or sore disorders pertaining to the heart”, this paper sorts out its related historical origin and modern extension, analyzes the relationship between the function of the heart and cancer pain, summarizes the corresponding treatment principles and methods, and improves the principle-method-formula-medicine system for the treatment of cancer pain from the perspective of the heart, thus attempting to open up a new way for the treatment of cancer pain.
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    TCM syndrome distribution in 302 patients with acute exacerbation of chronic obstructive pulmonary disease
    WANG Sheng,YE Hai-yong, CHEN Yue, JI Hong-yan,ZHU Chun-dong,REN Wei,LI Chun-ying, ZHOU Qun
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2015, 38 (1): 57-62.   DOI: 10.3969/j.issn.1006-2157.2015.01.013
    Abstract596)      PDF(pc) (1103KB)(522)       Save
    Objective To study the distribution of TCM syndromes of acute exacerbation of chronic obstructive pulmonary disease (AECOPD), so as to provide reference for clinical therapy. Methods After searching literatures of TCM syndromes of AECOPD in CNKI from the year 1997 to 2012, TCM syndrome Scale composed of TCM symptoms was established. 302 patients with AECOPD were inquired according to the listed symptoms on the TCM syndrome Scale. All the symptoms arisen from the survey were analyzed by cluster analysis and principal component analysis. Results AECOPD consists of four TCM syndromes:phlegm-heat obstructing lung with lung qi ascending counterflow, qi deficiency of lung-kidney with exogenous pathogenic factors, qi deficiency of lung- spleen with turbid phlegm obstructing lung, qi deficiency of spleen-kidney with qi stagnation and blood stasis. Conclusion Application of cluster analysis and principal component analysis to TCM syndrome of AECOPD is valuable for standardization and normalization of syndrome classification.
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    Textual research on author of Tuiqiu Shiyi (Ascertaining My Teacher’s Ideas)*
    ZHANG Xu, WANG Yulin
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2017, 40 (9): 718-721.   DOI: 10.3969/j.issn.1006-2157.2017.09.003
    Abstract345)      PDF(pc) (1150KB)(337)       Save
    There were different records about the author of Tuiqiu Shiyi (Ascertaining My Teacher’s Ideas) in the bibliographic books in past dynasties. Some of them referred to WANG Ji, and others to DAI Yuanli. Today’s publications and bibliographic books all refer to DAI Yuanli. But the preface of Tuiqiu Shiyi indicated that DAI Yuanli referred to the author was a guess at that time. General Catalogue of Complete Library of Four Branches of Literature · Ascertaining My Teacher’s thought that this book was one of Zhengzhi Yaojue (Important Tips to Analysis and Treatment of Patterns), Zhengzhi Leifang (Analogous Formulas for Analysis and Treatment of Patterns) and Leizheng Yongyao (Usage of Medicinal for Treating Analysis Patterns) written by DAI Yuanli. But the comparison among them shows that there are a few similarities between Tuiqiu Shiyi and Michuan Zhengzhi Yaojue Ji Leifang (Esoteric Important Tips and Analogous Formulas for Analysis and Treatment of Patterns). Also it is not unlikely that Tuiqiu Shiyi is a book in WANG Ji’s name. The author of Tuiqiu Shiyi requires further investigation.
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    Promotion mode of evaluation on sinews and bones for treating cervical spondylosis *
    Guo Guangxin, Kong Lingjun, Zhu Qingguang, Wu Zhiwei, Zhou Xin, Song Pengfei1, Xu Shanda, Lyu Zhizhen, Sun Wuquan, Fang Min, Cheng Yanbin
    JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE    2019, 42 (1): 84-88.   DOI: 10.3969/j.issn.1006-2157.2019.01.014
    Abstract368)      PDF(pc) (1250KB)(199)       Save
    The evaluation on sinews and bones in tuina of traditional Chinese medicine (TCM) re-fersto a systematic approach to evaluate the patient's physical state, so as to select appropriate tuina therapies and achieve safe and efficient goals. Through summarizing the characteristics of evaluation on sinews and bones in main schools of modern TCM tuina including assessments of bone landmarks, soft tissues and pain, and Western manual therapies including assessments of palpation of spine, postures (positions), pain and surrounding soft tissues, the key elements of promotion mode of evaluation on sinews and bones in TCM tuina are proposed, namely the evalu-ation on muscle tissue morphology, postures, tenderness points and joint motions. The purpose is to provide a reference for establishing a scientific, standard and feasible mode of evaluation on sinews and bones.
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    Comparison of different extraction methods on Gegen Qinlian Decoction *
    LUO Jing, BAI Xu, GULIZHAER, LI Shiyuan, JIN Su, WANG Xiuli
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2016, 39 (10): 860-863.   DOI: 10.3969/j.issn.1006-2157.2016.10.015
    Abstract376)      PDF(pc) (1237KB)(428)       Save
    Objective By comparing the efficacy and toxicity of three extraction Methods of Gegen Qinlian formula, so as to underline the appropriate technology of its extraction and preparation. Methods Mice were divided into blank group, pathological group, tablet group, pill group and decoction group, in which the latter three groups were divided into high-, mid- and low- dose subgroups respectively. The mice models were induced by i.g. senna decoction 20 mL/kg(4 g/kg). The tablet group were i.g. extract water solution at dose of 1.60, 0.80,0.40 g/kg, the pill group were i.g. at dose of 6,3 and 1.5 g/kg, and the decoction group at dose of 13,6.5 and 3.25 g/kg. The number of the wet dung was chosen to evaluate the antidiarrheic effect of Gegen Qinlian formula. Then the acute toxicity test of different samples was carried out through maximal dosage experiments. Mice were divided into tablet group, pill group and decoction group, with 10 mice in each group. And the maximum dosage were 0.66 g/mL(tablet), 0.63 g/mL(pill) and 0.74 g/mL(decoction), equivalent to crude drug pieces of 67.96, 89.01 and 177.77 g/kg, and equivalent to 24, 9 and 6 times daily dose of per kilogram of body weight of 70 kg. After the single dose administration, the reactions of the mice were observed for consecutive seven days. Results The sample of three dosage forms of Gegen Qinlian formula had obvious therapeutic effect ( P<0.001), among which the antidiarrheic effect of tablets was best ( P<0.05), pill less and decoction least. No death or obvious abnormalities was discovered under maximum dosage. Conclusion In the three preparations, Gegen Qinlian tablets extraction preparation method recorded in 2015 Chinese Pharmacopoeia had the best inhibitory effect against diarrhea caused by senna leaves.
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    Xin’an physicians of long family tradition in Ming and Qing Dynasties *
    Wan Simei, Liu Boshan, Wang Jian
    JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE    2018, 41 (4): 289-293.   DOI: 10.3969/j.issn.1006-2157.2018.04.005
    Abstract429)      PDF(pc) (1249KB)(587)       Save
    Physicians of long family tradition in Xin’an emerged as a unique TCM school in Ming and Qing dynasties. They inherited family medical techniques, excelled in clinical practice and their specialties covered almost all fields for generations, with a total population of no less than 300 people. This TCM physician group accounted for one third of all TCM physicians in Xin’an. They were featured by excellence in both medical practice and Confucian literature. They were scholars who studied medicine; they were also professional practitioners with profound theoretical studies and satisfactory clinical efficacy. The family tradition of TCM physician education in early Ming Dynasty, support for medical care from clan system in Huizhou in middle Ming Dynasty, and high respect for TCM physician in Ming and Qing Dynasty in Huizhou all contributed to the formation of Xin’an school of TCM physician group during that historical period.
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