Meta-analysis of clinical effect of Banxia Xiexin decoction on patients with chronic atrophic gastritis
2015, 38 (1):
Objective To evaluate the effect of chronic atrophic gastritis (CAG) treated with Banxia Xiexin decoction (BXD). Methods After searching randomized clinical trials (RCT)of treating CAG with Banxia Xiexin decoction with adopting strategy for literature search in CBM,CNKI and Wanfang database (excluding blinding), two reviewers independently screened titles/abstracts and full text reports of potentially eligible trials three times to identify studies for inclusion based on exclusive and inclusive criterion. Analytic studies which had reported relative risk (RR) , 95% confidence interval(CI), or required data to calculate them were included. Fixed effects model or random effects model was applied by heterogeneity between the studies. Results Nine RCTs with 594 cases were included. There was statistically significant between two groups(BXD group and control group) on clinical efficacy rate [RR=1.24,95％CI(1.07,1.45),P=0.004] , clinical curative rate [RR=1.67, 95％CI(1.13,2.49),P=0.01] , gastroscopy efficacy rate [RR=1.42,95％CI:(1.12,1.79), P=0.004] and gastroscopy curative rate [RR=1.96,95％CI:(1.34,2.86),P=0.000 6].There was no significant difference between two groups in Helicobacter Pylori eradication [RR=1.05,95％CI:(0.74,1.49), P=0.79] or intestinal metaplasia improvement [RR=1.23,95％CI:(0.96,1.58), P=0.10]. Conclusion Banxia Xiexin decoction had a significant effect on clinical and gastroscopy compared with control group . While further randomized trials with high-quality and low-risked bias are required.
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