主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    28 March 2015, Volume 38 Issue 3 Previous Issue    Next Issue
    On Chinese medicine essence based on drug system of natural pharmacy concept*
    SHI Ren-bing, WANG Yong-yan, LYU Song-tao
    2015, 38 (3):  149-152.  doi: 10.3969/j.issn.1006-2157.2015.03.001
    Abstract ( 592 )   PDF (1112KB) ( 539 )   Save
    Based on the nature medicine concept drug system, the epistemology of drug essence in traditional Chinese medicine (TCM) was set up, to improve understanding the essence of TCM drugs, effective material base level, and guiding research on the optimum drug system and drugs of TCM. The theories of applied science, reductionism, system theory, and holistic view were used for basic characteristic analysis of the drug system in TCM. Three basic characteristics of drug system (naturalness, collaborative and compatibility) reflect the organic integration effect state, natural related laws, related pharmacology and the connotation of the effective material basic in single and compound drugs of TCM. The research based on drug system thinking and its basic properties characterization, can perceive the essence and connotation of TCM from microscopic system. That also can guide the research on optimum drug of TCM, predict new drug system and new unit of TCM, and finally to enrich clinical drugs.
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    Thinking process of TCM diagnosis and treatment under psychological logics model*
    SUN Chao ,XIE Qing-yu,MENG Qing-gang
    2015, 38 (3):  153-157.  doi: 10.3969/j.issn.1006-2157.2015.03.002
    Abstract ( 714 )   PDF (1057KB) ( 771 )   Save
    To explore TCM doctors’ mode and the process of logical reasoning of TCM diagnosis and treatment, regarded reasoning modes as research objects, by adopting methods of epistemic logic. The TCM doctors’ thinking process of diagnosis and treatment is a composite model of thinking, consisted of three parallel channels of abductive reasoning, analogic reasoning and inductive reasoning and one serial channel of deductive reasoning. The process can also be influenced by experiences, conviction, emotion and other psychological factors. The model which contains complicated recognition psychology factors will contribute to interpretation of the process of TCM diagnosis and treatment on the whole, to open a new way of understanding and to provide further reference for the research on the cognitive schema.
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    Application of non-equilibrium thermodynamical theory in syndrome thermodynamics of TCM*
    LI Hong-juan,WANG Le-peng, WEI Ming,DENG Pin,SUN Tao
    2015, 38 (3):  158-161.  doi: 10.3969/j.issn.1006-2157.2015.03.003
    Abstract ( 649 )   PDF (1102KB) ( 1028 )   Save
    To interpret the TCM yin-yang theory by introducing the theory of non-equilibrium thermodynamics. By using infrared imaging technology, the regional calorific values on body surface corresponding to viscera and triple-energizer inside were presented on coordinate diagrams. The presentation was called human thermal structure which established the ideas and methods of thermodynamics of TCM syndrome. It put clearly forwards that healthy human thermal structure conformed to the dissipative structure, and the human thermal structure appeared differently in person with different TCM syndrome. So the treatment based on syndrome differentiation is adjustment of regional cold or heat deviation to restore normal human non-equilibrium thermal structure.
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    Systemically biological characteristics focused on pathogenesis: a novel idea of TCM scientific research*
    PAN Li-qun, YAO Chang, PAN Zi-hao, LI Yong-gang
    2015, 38 (3):  162-166.  doi: 10.3969/j.issn.1006-2157.2015.03.004
    Abstract ( 708 )   PDF (1059KB) ( 1375 )   Save
    It is inevitable for TCM researchers to find out right ways of TCM scientific research. Through the analysis of confusions faced with, TCM original thoughts with ancient background, practical research in teamwork and systems science, the basic research idea of Chinese medicine is summarized as the following: the core connotation of Chinese medicine presented as the relationship-centered theory, is the dominant position of pathogenesis as well as construction procedure of “Careful Card, Judge for Differentiation”. Regard systemical application of the integration of academic and technologies associated with life sciences as characteristics, we believe that the characteristics should be one of the appropriate routes to clarify the confusion existed in modern TCM research.
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    Effect of curcumin on expression of IRS-1 of double transgenic mice model with Alzheimer’s disease*
    DANG Hui-zi , WEI Peng, CHEN Xiao-pei, REN Ying, YANG Jin-duo, WANG Peng-wen
    2015, 38 (3):  167-171.  doi: 10.3969/j.issn.1006-2157.2015.03.005
    Abstract ( 662 )   PDF (1150KB) ( 613 )   Save
    Objective To observe the effect of curcumin on the expression of insulin receptor substrate-1 (IRS-1) and phosphated insulin receptor substrate-1( p-IRS-1) in the hippocampus of mice model with Alzheimer’s disease (AD), so as to explore the mechanism of neuro-protective effect of curcumin. Methods Three-month-old APP/PS1 double transgenic mice were randomly divided into model group, rosiglitazone group(10 mg/kg) and high-, mid-, low- dose curcumin groups(high-dose group, mid-dose group, low-dose group)with the dose of 400, 200 and 100 mg/kg (n=12 each). Non-transgenic mice of the same brood were selected as control group. After intragastric administration for six consecutive months, the protein expressions of IRS-1 and p-IRS-1 in hippocampus CA1 area were detected by immunohistochemistry and Western blot,and the mRNA expression of IRS-1 were detected by RT-PCR. Results IRS-1 positive cells of hippocampus CA1 area significantly increased in model group than those of normal group (P<0.01). Compared with model group, IRS-1 positive cells decreased(P<0.05 or P<0.01)significantly in rosiglitazone group and three curcumin groups, while the expression of p-IRS-1 increased in all four intervention groups(P<0.05 or P<0.01). Conclusion Curcumin can recover, to some extent, the protein contents of IRS-1 and p-IRS-1 in hippocampus CA1 area of APP/PS1 double transgenic mice. Furthermore, the expression of IRS-1mRNA can be down-regulated and insulin-signaling transmission of the APP/PS1 double transgenic mice can be improved. All these findings suggest that the potential mechanism of anti-AD effect of curcumin is by the way of regulating insulin signal transduction pathway.
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    Influence of extreme climate changes on lung immune function in rats*
    CAI Yue-chao,XU Xiao-ying,MA Shu-ran,HENG Yan
    2015, 38 (3):  172-175.  doi: 10.3969/j.issn.1006-2157.2015.03.006
    Abstract ( 514 )   PDF (1052KB) ( 417 )   Save
    Objective To explore the mechanism of immune function in rat’s lung exposed to the extreme climate conditions. Methods Altogether six extreme climate conditions of sharp increase in temperature, sudden drop in temperature, continued high temperature, continued low temperature, high temperature with high humidity and normal temperature with high humidity, were obtained by using artificial climate simulation system. Melatonin (MT), interleukin-10 (IL-10), interleukin-6 (IL-6) and secretory IgA (sIgA) extracted from bronchoalveolar lavage fluid (BALF) and lung tissues were detected by enzyme-linked immunosorbent assay (ELISA). Results The content of MT and IL-10 from lung tissue decreased significantly in the process of sudden changes in temperature (P<0.05), and there were significant differences in continued high temperature group and continued low temperature group (P<0.05,P<0.01). IL-6 and sIgA from BALF showed no significant differences in the process of sudden changes in temperature, while which changed significantly in continued high temperature group, continued low temperature group, high temperature with high humidity group and normal temperature with high humidity group(P<0.05), furthermore, those in both high humidity groups were more than continued high temperature group and continued low temperature group. Conclusion The extreme climate conditions influence lung immune function differently by the way of corresponding response of different immune factors.
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    Relationship between brightness of tongue color and peripheral red blood cell parameters: a study of 972 cases*
    YAO Xu-ying , LIANG Rong, CHEN Dong-ning, WANG Zhao-ping,LI Dan-xi, TIAN Ding ,WANG Sheng-hua
    2015, 38 (3):  176-181.  doi: 10.3969/j.issn.1006-2157.2015.03.007
    Abstract ( 564 )   PDF (1134KB) ( 392 )   Save
    Objective To investigate the correlation between brightness of tongue and the parameters of peripheral red blood cells (pRBC). Methods 972 subjects undergoing physical examination took Chinese medical diagnosis of tongue color and took photos of their tongues. Venous blood samples were collected, from which the parameters of pRBC were measured including blood cell count (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and red blood cell volume distribution width (RDW). After color rectification of the photos of the tongues, chromatic values were extracted from the margin of tongues for furthermore statistical analysis of relationship between tongue color and parameters of pRBC. Results Based on value of brightness (L value), all tongues were divided into four groups: pink tongue group, red tongue group, dark tongue group and bright tongue group. Significant difference (P<0.01) was shown in paired comparison. L values of women in pink tongue group and red tongue group were higher than those of men in the same groups(P<0.01). L value reduced with the increasing of the age in pink tongue group and bright tongue group (P<0.05 or P<0.01). That RBC, HGB and HCT of red tongue group and dark tongue group were higher than those of the other two groups, was related to age and gender. In bright tongue group, RDW of subjects at the age of 50 or above was higher than that of the other age groups. Conclusion The reduction of brightness of tongue color was related to the increasing of RBC, HGB, HCT and MCV. The brightness of tongue color is expected to be used to evaluate the condition of qi and blood.
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    Effect of antidepression and mechanism of regulation on IDO of Tiansi liquid*
    ZHOU Jing-yang,LU Yi,XU Xiang-qing, ZHANG Jing,LI Hai-na, CHANG Hong-sheng
    2015, 38 (3):  182-185.  doi: 10.3969/j.issn.1006-2157.2015.03.008
    Abstract ( 697 )   PDF (1118KB) ( 636 )   Save
    Objective To study the effect of antidepression of Tiansi Liquid,a TCM basic prescription for treating amnesia and palpipation, which influences on indoleamine 2, 3-dioxygenase (IDO), the key metabolism enzyme of the tryptophan-kynurenine pathway. Methods The mice model of depression was established by intraperitoneal injection of 1 mg/kg lipopolysaccharide (LPS). The immobility time in forced swimming test was collected by Noldus EthoVision XT9 system. The content of tryptophan and kynurenine in brain tissue were detected by HPLC-MS/MS technique. The mRNA expression level of IDO and NF-κB in brain tissue were measured by using real-time PCR. Results Four hours after the injection of LPS in model group, the immobility time of mice was prolonged (P<0.05), while the activity of IDO in brain tissue and the mRNA expression level of IDO and NF-κB increased significantly(P<0.01). Tiansi liquid shortened the immobility time of mice (P<0.05) , and inhibited the activity of IDO and the expression of IDO and NF-κB mRNA (P<0.01). Conclusion Antidepressant-like drug effect of Tiansi liquid is due to inhabiting directly and indirectly effects of NF-κB on IDO which is activated by inflammatory cytokines.
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    Anti-inflammatory effect of Mongolian medicine compound Sendeng- 4 on adjuvant arthritis in rats*
    BAI Pu, XIN Sha-sha, DONG Yu
    2015, 38 (3):  186-189.  doi: 10.3969/j.issn.1006-2157.2015.03.009
    Abstract ( 552 )   PDF (1056KB) ( 444 )   Save
    Objective To study the therapeutic effect of effective part of Sendeng- 4, a Mongolian medicine compound, on rat model with adjuvant arthritis (AA). Methods SD rats were randomly divided into five groups: effective part of Sendeng- 4 group (Sendeng- 4 group), Tripterygium wilfordii Hook F. group (TWHF group), celecoxib group, model group and normal group. Except the normal group, the other groups were made into AA model induced by injection complete Freund’s adjuvant into both rear voix pedis twice and were orally administrated corresponding drugs for 20 consecutive days after the second immunization. The rat paw swelling degree were calculated by measurement of the volume of rat paw. The concentration of serum tumor necrosis factor-α (TNF-α), prostaglandin-2 (PGE2) and interleukin-6 (IL-6) were detected by using ELISA kit. Results Compared with model group, the rat paw swelling degree decreased significantly in Sendeng- 4 group, TWHF group and celecoxib group(P<0.05), while, those of the three treatment groups had no difference compared with normal group. Compared with model group, the concentration of TNF-α, PGE2 and IL-6 decreased significantly in three treatment groups(P<0.05) . Conclusion Mongolian medicine Sendeng- 4 inhibites TNF-α, PGE2 and IL-6 in serum which are regarded as rheumatoid arthritis inflammatory cytokines, leading to effective treatment of the patients of rheumtoid arthritis.
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    Effects of Yiqi Huoxue formula and Bushen Shengsui formula on expression of Wnt3a,Frizzled9 and TCF3 in hippocampus of rats with ischemia-reperfusion injury*
    SONG Zu-rong,WANG Jian,HU Jian-peng,XU Wei
    2015, 38 (3):  190-194.  doi: 10.3969/j.issn.1006-2157.2015.03.010
    Abstract ( 777 )   PDF (1126KB) ( 1701 )   Save
    Objective To study the effects of Yiqi Huoxue formula (YQHX) and Bushen Shengsui formula (BSSS) on the protein expression of Wnt3a,Frizzled 9 and TCF3 on Wnt/β-catenin pathway in hippocampus of rat model induced by middle cerebral artery ischemia/reperfusion. Methods The focal cerebral ischemia/ reperfusion rat model was established by intraluminal thread occlusion of the middle cerebral artery (MCAO)for 2-h followed by 7-d reperfusion. The rats were randomly divided into sham group, model group, YQHX group and BSSS group(each n=10). The expression of Wnt3a, Frizzled9 and TCF3 protein in hippocampus of cerebral ischemia were detected by Western-Blot assay,and those in CA1 zone of cerebral ischemia were measured by using immunohistochemistry Envision two-step method. Results The relative expression of Wnt3a,Frizzled 9 and TCF3 protein in both hippocamous and CA1 zone increased significantly in model group compared with sham group (P<0.01). Compared with model group, the expression of those three proteins in both hippocamous and CA1 zone decreased significantly in YQHX group and BSSS group (P<0.05). Conclusion Yiqi Huoxue formula and Bushen Shengsui formula can promote the repairment of injured cerebral tissue by the way of reducing the protein expression of Wnt3a,Frizzled9 and TCF3 in hippocampus to regulate Wnt/β-catenin signal pathway.
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    Quality characteristics and correlation analysis of medicinal preparations from Xiongshao Fang*
    CHI Lei,SUN Ya-shu,YANG Shu-juan,PAN Ting,WEN Jing,HUANG Ya-ting,LI Huan-juan,ZHANG Lu,PENG Ping,JIANG Yan-yan,SHI Ren-bing
    2015, 38 (3):  195-200.  doi: 10.3969/j.issn.1006-2157.2015.03.011
    Abstract ( 601 )   PDF (1339KB) ( 501 )   Save
    Objective To determin the key factors affecting the quality of Xiongshao Fang and the best preparation forms of medicinal in Xiongshao Fang, laying the groundwork of anti-migraine drug from Xiongshao Fang. Methods Based on drug system, the content of effective index components of preparation of Xiongshao Fang was detected by using HPLC-PDA. The quality of medicinal preparation from Xiongshao Fang were characterized based on the content, relative quantity, relative ratio of content, yield rate and anti-migraine effect, and the characterized results were given correlation analysis. Results The effect of anti-migraine of three medicinal preparations from Xiongshao Fang was listed in the following descending order of enrichment, ethanol extract, and water extract. The enrichment was the best preparation form of medicinal in Xiongshao Fang with the highest content of effective index components, lowest extract rate, lowest dosage and best effect of anti-migraine, resulted from the medicine-efficacy correlation analysis. Conclusion The method of the determination of effective index components from Xiongshao Fang is easy to handle, accurate and highly reproducible. Based on the basic composition and extraction rate of medicinal system, the key factor of increasing medicinal efficacy is promotion of the content and optimization of proportion of the relative effective components.
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    Fingerprints for characterization of nine compatibility formula and optimization of compatibility formula engaged in activating blood and resolving stasis :a study for Sanhuang Xiexin decoction composed of Radix et Rhizoma rhei, Radix scutellariae and Rhizoma coptidis*
    LI Peng-Yuan, LI-Li, LIANG Ri-xin, WANG Lan, LIU Yin, MA Yin-Lian, YU Ding-rong, YAO Jia-qi , XIAO Yong-Qing
    2015, 38 (3):  201-205.  doi: 10.3969/j.issn.1006-2157.2015.03.012
    Abstract ( 942 )   PDF (1414KB) ( 868 )   Save
    Objective To characterize the distribution of fingerprints of nine different compatibility formula (Formula 1~9) of Radix et Rhizoma rhei, Radix scutellariae and Rhizoma coptidis, three Chinese herbal medicines that comprise Sanhuang Xiexin decoction; to analysis the components of each formula, from which best effects of activating blood and resolving stasis were obtained. Methods High performance liquid chromatography (HPLC) was performed with Agilent C18 column, acetonitrile and 1% formic acid gradient elution, detection wavelength at 280 nm, column temperature of 30℃. Results 24 characteristic peaks were included in each fingerprint of compatibility formulae, and 9 peaks were identified with chemical reference. Formula 7, whose proportion of baicalin, anthraquinone glycosides, anthraquinones aglycone and berberine hydrochloride was 2.8∶1.7∶1.6∶1.0 approximately, was determined to be optimal to activating blood and resolving stasis. Conclusion The methods established of fingerprints and component analysis are stable and reliable to be used for quality control of component compatibility formulae. Furthermore, components analysis of Formula 7, the optimal formula for activating blood and resolving stasis, is expected to explore the correlation between compatibility and effect.
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    Effects of Yifei Huoxue granule on quality of life and pulmonary function in patients with stable chronic obstructive pulmonary disease*
    OU Min, ZHANG Chao, SONG Xiu-jie, WU Ni
    2015, 38 (3):  206-208.  doi: 10.3969/j.issn.1006-2157.2015.03.013
    Abstract ( 570 )   PDF (1037KB) ( 434 )   Save
    Objective To explore the effect of Yifei Huoxue granule on the pulmonary function and quality of life in patients with chronic obstructive pulmonary disease (COPD) at stable stage. Methods Altogether 128 stable COPD patients were randomly divided into treatment group (n=68) and control group (n=60). The control group undertook conventional western medicine treatment, while the treatment group was treated with the combination of conventional western medicine and orally administration of Yifei Huoxue granule. On the day before treatment and at the end of the twelve-week treatment, pulmonary function was tested, and the general health status were evaluated by using six-minute walk test (6MWT) and St George’s Respiratory Questionnaire (SGRQ). Results After treatment, FEV1, FEV1% and FEV1/FVC% in treatment group were significantly increased (P<0.05) compared with pre-treatment, while there was no statistical difference in control group. Furthermore, FEV1, FEV1% and FEV1/FVC% in treatment group were significantly higher than those in control group (P<0.05) after treatment. Both respiratory symptom score and total score of SGRQ in treatment group were significantly decreased (P<0.01) after treatment, which were significantly lower than those in control group (P<0.05). Activity score in treatment group was significantly decreased (P<0.05).The value of 6MWT was higher after treatment (P<0.05) in treatment group, but there was no significant difference between treatment group and control group. Conclusion Yifei Huoxue granule improved markedly pulmonary function exercise tolerance and quality of life of COPD patients.
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    Citation Data analysis of Journal of Beijing University of Traditional Chinese Medicine in CSCD, CSTPCD and CA from 2009 to 2013*
    ZHANG Chi, LIANG Ji-chun,YOU Hai-yan, BAI Jin, LU Guang-lin, LI Yan
    2015, 38 (3):  212-216.  doi: 10.3969/j.issn.1006-2157.2015.03.015
    Abstract ( 664 )   PDF (1067KB) ( 395 )   Save
    After searching the citation data from 2009 to 2013 of Journal of Beijing University of Traditional Chinese Medicine (JBUTCM)from Chinese Science Citation Database (CSCD), Chinese Science and Technology Papers and Citation database (CSTPCD) and American Chemical Abstract (CA), bibliometrics index of source journal and influence in CSCD, total citation frequency, impact factor and total score in CSTPCD, total amount and total proportion of articles included by CA were obtained. Meanwhile, number of average reference, unit distribution and ratio of funded paper between CSCD and CSTPCD were compared. Furthermore, altogether 31 papers, regarded as top-notch academic papers, included by F5000 Project carried by Institute of Scientific and Technical Information of China were listed. The results are useful to evaluate the position of JBUTCM among domestic scientific journals, and to improve quality and academic level.
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