Study on classification of TCM syndromes of Hp-related chronic gastritis
2014, 37 (3):
Objective To study the syndromes and syndrome factors of Helicobacter pylori (Hp)-related chronic gastritis, and discuss the expressions of TCM syndromes of Hp infection. Methods The patients with non-atrophic gastritis and atrophic gastritis (each n=200) were chosen, and their data from TCM four examinations were analyzed by using factor analysis and entropy-reactor of complex system. Results There were 4 syndrome factors related to disease locations of Hp-positive chronic gastritis, including liver, stomach, spleen and gallbladder (gallbladder being given up after clinical and expert questionnaire), and there were 3 of Hp-negative chronic gastritis, including liver, stomach and spleen. There were 9 syndrome factors related to disease nature of Hp-positive or Hp-negative chronic gastritis, including qi deficiency, yin deficiency, yang deficiency, qi stagnation, phlegm, heat, blood stasis, food accumulation and cold. There were 8 basic syndrome types, including para-syndrome of depression-heat in liver and stomach, para-syndrome of spleen-stomach weakness, para-syndrome of damp-heat accumulation, para-syndrome of food stagnation, para-syndrome of spleen cold and stomach heat, para-syndrome of stomach yin deficiency, para-syndrome of liver qi invading stomach and para-syndrome of stasis in stomach collateral. After Chi-square test, the distribution of the syndrome factors related to disease nature had no difference between Hp-positive chronic gastritis and Hp-negative chronic gastritis, but that of basic syndrome types had difference. The results of pairwise comparison showed that Hp infection was significantly correlated to syndrome distribution (P<0.01), and it was most closely related to para-syndrome of stomach yin deficiency and followed by para-syndrome of spleen-stomach weakness, para-syndrome of damp-heat accumulation and para-syndrome of depression-heat in liver and stomach. Conclusion Hp infection is correlated to dampness and heat, especially to yin deficiency. As a kind of external pathogenic factor, the evil nature of Hp is closely related to heat and dampness and more closely to heat, which is easy to cause impairment of yin.
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