主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    15 April 2015, Volume 38 Issue 4 Previous Issue    Next Issue
    Orignal Article
    Mental image theory of Chinese traditional philosophies applied to traditional Chinese medicine (Ⅳ): mental image and clinical practice of traditional Chinese medicine*
    FAN Yi-pin, ZHANG Zhi-bin, WANG Yong-yan
    2015, 38 (4):  221-224.  doi: 10.3969/j.issn.1006-2157.2015.04.001
    Abstract ( 459 )   Save
    The application of mental image in clinical practice of TCM reflects the thinking process of syndrome differentiation and treatment. The process, which is undertaken on the “mind”, one of forms of representation of mental image, can be summarized in understanding of image, collection of image, storage and decision of image, examination and analysis of image, confirmation of image.
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    Effect of needling sensation in acupuncture treatment on uterine in primary dysmenorrheal rats of cold stagnation syndrome*
    QI Dan-dan, ZHANG Lu-fen, ZHANG Ling, SHEN Song-xi, ZHU Shi-peng, REN Xiao-xuan, GUO Meng-wei, ZHAO Ya-fang, LI Xiao-hong, JI Bo, ZHU Jiang
    2015, 38 (4):  228-232.  doi: 10.3969/j.issn.1006-2157.2015.04.003
    Abstract ( 419 )   Save
    Objective To investigate the effect of needling sensation (de qi) when acupuncturing at Sanyinjiao point (SP6) on the uterine contractions, uterine microcirculation and the body torsion reaction in primary dysmenorrheal (PD )rat model with cold stagnation syndrome.Methods 96 anestrous female SD rats were divided into four groups (n=24 each) of saline control group(control group), PD model with syndrome of cold stagnation group(model group), acupuncture treatment with obtaining “de qi ”sensation group(deqi group)and acupuncture treatment without obtaining “de qi ”sensation group (no deqi group). Rat model with PD was induced by whole body freezing combined with intraperitoneal injection of estradiol benzoate. After modeling, bilateral Sanyinjiao points (SP6) of rats were stimulated by acupuncture, and the indexes of uterine contraction, uterine microcirculation and the body torsion reaction were recorded and analyzed. Results Compared with control group, the uterine activity increased significantly in model group. The number of uterine contraction wave and uterine activity decreased markedly in deqi group compared with model group. The diameter of capillaries and microvessels of uterine decreased significantly in both model group and no deqi group compared with control group, while microvessel relaxation at each time point and capillaries relaxation at 40, 50, 60 min after acupuncture in deqi group were observed. Meanwhile, compared with model group, writhing times and scores decreased markedly with writhing latency increasing in deqi group.Conclusion The effect of relieving uterine contraction and improving uterine microcirculation in deqi group maybe relies on obtaining needling sensation, which is the key of efficacy of acupuncture treatment.
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    Intervention of Feixian Formula extract on pulmonary microvascular endothelial cell migration and angiogenesis in vitro in rat model of pulmonary fibrosis*
    LIU Zhe, ZHANG Xiao-mei, YIN Ting, QIN Hui-hui, ZHANG Li-yuan, CHEN Liang, HUANG Yan-fang
    2015, 38 (4):  233-235.  doi: 10.3969/j.issn.1006-2157.2015.04.004
    Abstract ( 418 )   Save
    Objective To probe into the mechanism of Feixian Formula(FXF), a Chinese herbal compound, in prevention pulmonary microvascular endothelial cells (PMVECs) migration and angiogenesis in vitro. Methods PMVECs isolated from rat model of pulmonary fibrosis (PF) were cultured and divided into blank group, losartan group, prednisone group, low-, mid-, and high-dose of FXF groups. Migrating cells and new vessels in each group were counted. Results High-dose and mid-dose of FXF and losartan inhibited PMVECs migration significantly (P<0.05).High-dose, mid-dose, low-dose of FXF and losartan inhibited formation of new vessels, even high-dose of FXF completely inhibited blood vessel formation. Conclusion The potential mechanism of anti-pulmonary fibrosis of FXF in vitro is related to inhabitation of PMVECs migration and new vessels formation.
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    Influence of different acupoints and intensity of stimulus on HPT axis in rats with syndrome of kidney-yang deficiency: a study based on orthogonal experimental design*
    MIN You-jiang,YAO Hai-hua,ZHANG Hui,DINGLI Li-qiang,MIN Zhi-yun,PEI Jia ,CHENG Li-hong
    2015, 38 (4):  236-240.  doi: 10.3969/j.issn.1006-2157.2015.04.005
    Abstract ( 398 )   Save
    Objective To study the operational parameters of acupuncture treatment for rats model of kidney-yang dificiency syndrome, with serum T3, TSH and hypothalamic TRH mRNA as indicators, and to find the main influencing factors and an optimal combination of factors so as to provide experimental evidence. Methods Rat model of kidney-yang deficiency syndrome was induced by intramuscular injection of hydrocortisone. L9 (34 ) orthogonal experiment was designed with four factors viz. acupoint, angle of twisting-rotation(angle), frequency of twisting-rotation (frequency), duration of twisting-rotation (duration) at three levels respectively. The rats were treated by acupuncture manipulation device controlled by computer. Serum T3 and TSH were measured by using ELISA, and the expression of hypothalamic TRH mRNA was determined by using RT-PCR. Results Frequency was the primary factor (P<0.01), duration was the secondary factor(P< 0.01 or P<0.05) and acupoint was the tertiary factor(P< 0.05 ). The optimal acupuncture factors were acupoint of Shenshu (BL23) , angle of 90°, frequency of 120 times/min and duration of 60 s or 120 s. Conclusion Frequency and duration were the essential factors of intensity of acupuncture, which were also the important factors to influence of acupuncture.
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    Quality representation and correlation analysis of Fructus Perillae based on characteristic spectrum of medicinal system*
    TANG Xue-yang , AN Qi, SUN Dao-han, WEN Jing , LU Guang-ying, XU Shu-ya, HUANG Ya-ting, LI Gang, JIANG Yan-yan , SHI Ren-bing
    2015, 38 (4):  241-246.  doi: 10.3969/j.issn.1006-2157.2015.04.006
    Abstract ( 445 )   Save
    Objective To establish the quality representation and correlation analysis method based on the characteristic spectrum of medicinal system of Fructus Perillae (Zisuzi), so as to evaluate quality of Zisuzi pieces effectively and accurately. Methods Using established HPLC-PDA method to characterize the quality of Zisuzi characteristic spectrum of medicinal system. The quality of 15 batches of Zisuzi pieces was represented according to the number and chemical type of characteristic peaks on characteristic spectrum, and the quantity of 15 batches of Zisuzi pieces was represented based on the content of three characteristic index components of luteolin, apigenin,rosemary acid, flavonoids (represented by luteolin) and phenolic acids (represented by rosemary acid). Correlation analysis of quality and quantity representations was then performed referring to the benchmark pieces. Results As the reference substance, characteristic spectrum of Lot.15 contains 12 characteristic peaks, 5 peaks of flavonoids and 7 peaks of phenolic acids, which all appeared on the chromatograms of 15 batches Zisuzi pieces.Lot.15,6,9,10,2,5,7 Zisuzi pieces had more effective index components. After comprehensive evaluation of more total effective index components of Lot.6, 12, 11, 7, 4, 14 ,10 and high correlation degree of Lot. 6, 12, 11, 7, 4, 14, 10 correlated with Lot. 15, the quality of Lot. 15, 6, 7, 10, 2, 5, 9, 12, 11,14 were judged to be better. Conclusion The established HPLC method by quality and quantity representation of characteristic spectrum of 15 batches of Zisuzi pieces is simple and accurate. And the evaluation mode of quantity and quality and their correlation based on Zisuzi medicinal system, concerning on systemic correlation and application validity, can evaluate the quality of Zisuzi pieces effectively and accurately.
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    Quality evaluation of Radix Saposhnikoviae by using grey relational analysis*
    LI Shuo, WANG Wen-quan, HOU Jun-ling, LI Wen-yan
    2015, 38 (4):  247-252.  doi: 10.3969/j.issn.1006-2157.2015.04.007
    Abstract ( 468 )   Save
    Objective To evaluate the quality of Radix Saposhnikoviae (Fangfeng) by using grey relational analysis. Methods The content of six characteristic components of alcohol extract, total polysaccharides, prim-O-glucosylcimifugin, cimifugin, 4′-O-beta-glucopyranosyl-5-O-methylvisamminol and sec-O-glucosylhamaudo were determined in altogether 20 Fangfeng samples. Based on grey relational analysis, the model of quality evaluation was established, by measuring the relative correlation defined. Results The results of quality evaluation were in accordance with the market quality grade of these 20 Fangfeng samples. Conclusion The study is expected to provide a novel way to classify the quality grade and evaluate the quality of Fangfeng in market.
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    Preparation and in vitro evaluation of analgesic microemulsion cataplasm*
    ZHANG Ye-wen, WANG Qiong, YU Jing-xin, LI Hui, KANG Qian, ZHANG Qing, TAN Peng, WU Qing
    2015, 38 (4):  253-259.  doi: 10.3969/j.issn.1006-2157.2015.04.008
    Abstract ( 486 )   Save
    Objective To investigate the influence of microemulsion technology on release capability and transdermal permeability of components in cataplasm. Methods With the initial bonding strength, 180 degree force strength and sensory evaluation scores as indicators, the formula of the analgesic microemulsion cataplasm matrix was optimized by using single factor experiment combined with central composite design-response surface design methodology. Modified Franz diffusion cell was used to compare the release capability and transdermal permeability between analgesic microemulsion cataplasm (MEC) and analgesic common cataplasm (CC) with indicators of ferulic acid and imperatorin. Results Optimized matrix formula was NP700, carbomer 941, carbomer 934, aluminum compounds, tartaric acid and glycerin with the ratio of 1∶0.1∶0.25∶0.04∶0.04∶6 . The release capability in vitro of ferulic acid and imperatorin in MEC and CC conformed to zero-order kinetic equation with a dual mechanism of diffusion and dissolution. The steady-state permeation rate of ferulic acid in MEC was 1.92 μg/(h·cm2) and that in CC was 0.97 μg/(h·cm2); that of imperatorin in MEC was 0.28 μg/(h·cm2), while in CC was 0.09 μg/(h·cm2). Compared with CC, the cumulative release rate of effective components multiplied. Conclusion Microemulsion technology can significantly promote the transdermal permeability of components in cataplasm.
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    Distribution of common syndrome elements of disease nature in 801 patients with viral hepatitis cirrhosis: a comparison between compensation stage and discompensation stage*
    ZHAO Li-hong,WANG Tian-fang, XUE Xiao-lin,WU Xiu-yan,LI Ning,LI Yong-gang,LI Xin,CHEN Sheng-duo, SUN Feng-xia,LI Xiu-hui,MAO De-wen,LIU Yan-ling,ZHANG-Chang,LIU Wen, ZHANG Qiu-yun
    2015, 38 (4):  260-265.  doi: 10.3969/j.issn.1006-2157.2015.04.009
    Abstract ( 458 )   Save
    Objective To discover the rules of distribution and combination of common syndrome elements in vital hepatitis cirrhosis(VHC) patients based on the method of combination of syndrome and diseases, so as to guide the TCM clinical practice.Methods A national multicenter and cross-section epidemiological survey was conducted by using Information Collection form of Vital Hepatitis Cirrhosis drafted by the research group to collect the TCM symptoms, tongue manifestation and pulse condition.Based on consensuses on clinical diagnosis and treatment of VHCliterature review, Standard of Hepatitis Cirrhosis Syndrome Elements Differentiation was established after two-round experts approval, on which the syndrome elements of 801 patients were determined.Descriptive statistics and Chi-square test were applied. Results Altogether 7 syndrome elements of disease nature lied in 801 patients with viral hepatitis cirrhosis:517 cases of qi deficiency, 503 cases of blood stasis, 462 cases of water retention, 448 case of yin deficiency, 438 cases of qi stagnation, 428 cases of yang deficiency and 257 cases of damp heat, in addition, the frequency of qi deficiency, blood stasis, damp heat and yang deficiency was higher at discompensation stage than that of the compensation stage (P<0.05). In 314 patients of compensation stage, the frequency of blood stasis (36.36%), qi deficiency & qi stagnation(20.00%), qi deficiency & yin deficiency & blood stasis(11.32%), qi deficiency & yang deficiency & yin deficiency & qi stagnation(16.13%) and qi deficiency & yang deficiency & yin deficiency & qi stagnation & blood stasis(45.1%) was the highest in distribution of single and combination of syndrome elements, respectively.In 487 patients of discompensation stage, the frequency of water retention (90.91%), qi deficiency & water retention(57.45%), qi deficiency & blood stasis & water retention(26.44%), qi deficiency & yang deficiency & blood stasis & water retention(23.40%) and qi deficiency & yang deficiency & qi stagnation & blood stasis & water retention(25.00%) was the highest, respectively.With regard to combination of six types of syndrome elements, water retention was not included in 60.00% patients at compensation stage, and damp heat was not included in 59.61% patients at discompensation stage. Conclusion Single type of element and combinations of two, three, four or five types of syndrome elements were more in patients of compensation, by contrast, combination of three, four, five, six or seven types of elements were more in patients of discompensation.Qi deficiency and blood stasis were the basic pathogenesis in patients of compensation and discompensation stage, and pathogenesis features showed differently at different stages.
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    Distribution of TCM syndrome elements in patients with diabetic nephropathy:a literature review*
    SUN Chao ,XIE Qing-yu,MENG Qing-gang
    2015, 38 (4):  266-270.  doi: 10.3969/j.issn.1006-2157.2015.04.010
    Abstract ( 452 )   Save
    Objective To reveal the distribution of the TCM syndrome elements in patients with diabetic nephropathy(DN), by searching the literature of TCM diagnosis and treatment on DN.Methods Relevant literatures on treating DN by syndrome differentiation of TCM were retrieved in CNKI, Wangfang Data and VIP from the beginning to August 9th, 2014. Syndrome elements of disease nature or of disease location were analyzed from 159 eligible literature divided into two parts: syndrome differentiation only (n=111) and syndrome differentiation combined with clinical stage (n=48). Results From the litrature of syndrome differentiation only, kidney and spleen were the most common syndrome elements of disease location, while yin deficiency was the most common syndrome elements of disease nature. By the contrast, from the literature of syndrome differentiation combined with clinical stage, the main syndrome elements of location were kidney, spleen and liver and the most common syndrome element of nature was yin deficiency at early stage; at middle stage, the main elements of location were kidney and spleen and of nature was deficiency syndrome including yin deficiency, yang deficiency and qi deficiency; at end stage, the main elements of location were still kidney and spleen and of nature was yin-yang deficiency. Conclusion Study on syndrome elements of DN from literature is favorable for standardization of clinical syndrome differentiation and providing reference for therapy.
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    Safety and effectiveness of Qilu Xiaobai formula on chronic kidney disease patients at second to third stage with syndrome of spleen-kidney deficiency and phlegm-stasis obstructing collateral*
    SU Zhong-hao, YANG Xue-jun, GAO Jian-dong, WANG Chen, LIU Wei-fang,LI Ying-qiao, YE Jin
    2015, 38 (4):  271-276.  doi: 10.3969/j.issn.1006-2157.2015.04.011
    Abstract ( 460 )   Save
    Objective To study the effectiveness and safety of Qilu Xiaobai formula (QLXB), a Chinese herbal compound formulated by the TCM principle of invigorating spleen and restoring virility with dredging collateral and removing damp, on chronic kidney disease(CKD) patients at stage 2~3 with syndrome of spleen-kidney deficiency and phlegm-stasis obstructing collateral. Methods 55 outpatients were divided randomly into Western medicinal group (n=18) and QLXB group (n=37). All the patients in two groups were treated basic therapy, besides, those in Western medicinal group took orally losartan while QLXB group took QLXB formula for 24 weeks. At the time point of 0, 8, 16 and 24 week, score of symptoms and score of syndrome were calculated by completing a questionnaire, serum creatinine (Scr), blood urea nitrogen(BUN), urinary protein in 24-hour(24UP) and glomerular filtration rate(eGFR) were measured. Results There was no statistical difference of each index between two groups before treatment (P>0.05). After treatment, symptom scores of QLXB group were significantly lower than those in the Western medicinal group (P<0.05). The score of soreness of loins and fatigue was significantly decreased in QLXB group than that in Western medicinal group (P<0.05). The concentration of Scr,Bun,24 UP and eGFR was significantly lower in QLXB group than Western medicinal group (P<0.05). Conclusion QLXB was safe and effective for treatment of CKD patients at stage 2~3.
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    Exploration of acupuncture prescriptions for chronic low back pain: a review of ancient and modern literature*
    JIANG Hui-li, JI Li-li, REN Xiu-jun, LONG Xian-qi, TU Ya
    2015, 38 (4):  280-283.  doi: 10.3969/j.issn.1006-2157.2015.04.013
    Abstract ( 565 )   Save
    Objective To reveal the rules of acupuncture treatment for chronic low back pain (CLBP) by searching ancient and modern literature. Methods After reviewing the ancient books and records from Spring and Autumn Period to Qing Dynasty and clinical treatment articles in recent 10 years from CNKI, Wangfang Data and VIP, the acupuncture prescriptions of treatment for CLBP were collected and analyzed. Results Distant acupoints and single acupoint were widely selected in ancient times, by the contrast, distant acupoints combined with local acupoints and mulitiple acupoints were the main selection of modern acupuncture practitioner. The acupoints selected were mostly five transport points, crossing points and back-shu points which located on foot-Taiyang meridians, DU meridians and foot-Shaoyang meridians. Conclusion Selecting distant acupoints and combination of the distant-local acupoints were the core of acupuncture prescriptions for treatment of CLBP.
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    Investigation of residents’ demand for community healthcare of Traditional Chinese medicine in Beijing*
    LUO Fu-Jian,WANG Song-Ying,GAO Li-Min
    2015, 38 (4):  284-288.  doi: 10.3969/j.issn.1006-2157.2015.04.014
    Abstract ( 471 )   Save
    Objective To find out the influence factors on demands for community healthcare of TCM in Beijing, and to provide evidence for promotion of TCM healthcare service. Methods 900 residents in three communities were included to complete the questionnaire, with recovery rate of 99.4% (895/900). Besides, each principal of the community healthcare institute was reviewed. Results 57.1% of the residents hoped to obtain TCM healthcare knowledge on TV or broadcast. 51.1% of hypertension patients, 49.6% of degenerative bone and joint disease patients, 47.0% of diabetes patients and 44.6% of constipation patients expected to be treated by TCM healthcare service. 34.7% of residents would receive cupping treatment, 28.9% would receive acupuncture, 22.5% would be massaged, 21.9% and 21.7% would take medicinal diet and herbal paste correspondingly. However, if TCM healthcare services are not included in the medical insurance system, only 26.5% of residents would receive them. Conclusion Elderly persons and chronic disease patients had strong demands for TCM healthcare services. The ratio of men who would take cupping treatment and massage was more than that of women. Acupuncture treatment and medicinal diet were the most common choice in elderly persons. The acceptability of residents taking herbal paste and cupping treatment was positively correlated with their educational level. As the results, according to different demands, promotion strategy and methods should be performed to speed up the popularization of TCM healthcare in community.
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