Effects of Chaiqi decoction on glucose and lipid metabolism and insulin resistance in rat model with metabolic syndrome*
2015, 38 (9):
Objective To study the effects of Chaiqi decoction (CQD)at different doses on glucose and lipid metabolism and insulin resistance(IR) in metabolic syndrome (MS)rat model. Methods The MS rat model was induced by feeding diet of high fat, high sugar and high salt. Altogether 56 male rats were randomly divided into normal group(n=16), model group(n=16), CQD low dose group(low-dose group, n=8), CQD middle dose group(mid-dose group, n=8) and CQD high dose group(high-dose group, n=8). The low-, mid-, and high- groups were taken CQD by intragastric administration at dose of 1.90, 5.71 and 17.13 g/kg daily for four weeks. At the end of the 8th week, eight rats of normal group and model group were sacrificed, and at the end of the 12th week, all the rats in each group were sacrificed. Serum TG, TC, HDL-C, LDL-C, fasting blood glucose (FBG) and fasting insulin (FINS) were detected, while insulin resistance index (IRI) was calculated. Results After taking CQD for four weeks , compared with model group, FINS and TG in low-dose group decreased significantly (P<0.05) while HDL-C increased significantly (P<0.05); FINS, TG, TC, IRI decreased significantly while HDL-C increased significantly in both mid- and high- dose groups (P<0.05). Conclusion CQD would attenuate the lipid metabolism of rats with metabolic syndrome and reduce IR. Furthermore, the mid-dose group and high-dose group got better effects than those of low-dose group.
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