Evolvement characteristics of TCM syndrome types of chronic gastritis: a clinical study of 592 patients*
2015, 38 (11):
Objective To explore the evolvement rule of TCM syndrome types of the transformation of chronic gastritis (CG) : from chronic non-atrophic gastritis (CNAG) , chronic atrophic gastritis (CAG) to precancerous lesions of gastric carcinoma (PLGC). Methods Based on gastroscopy and gastrobiopsy, altogether 592 patients included from three hospitals affiliated to Beijing University of Chinese Medicine Dongzhimen Hospital, (Dongfang Hospital and Third affiliated Hospital) and Wangjing hospital of China Academy of Chinese Medical Sciences from September 2013 to February 2014, were diagnosed with CNAG (338 cases), CAG (134 cases) and PLGC (120 cases). By using Epidata 3.1 the database was established, then principal component analysis, factor analysis and Chi-square test were conducted by using software SPSS 17.0. Results There were nine common syndrome types in CNAG, and the three leading ones were syndrome of incoordination between spleen and stomach, syndrome of heat-stagnation in liver and stomach, syndrome of incoordination between liver and stomach. There were ten syndrome types in CAG, and the highest frequency was syndrome of incoordination between liver and stomach, then syndrome of static blood in stomach collaterals and syndrome of deficient cold of spleen and stomach. The highest frequency of three syndrome of ten in PLGC were syndrome of yin deficiency in stomach, syndrome of yang deficiency in stomach and syndrome of static blood in stomach collaterals. The frequencies of location factors of CNAG from high to low were stomach, liver and spleen, the same as those of CAG; the frequencies of nature factors from high to low were qi stagnation, heat, qi deficiency, dampness and yang deficiency, which were some different from those of CAG being qi stagnation, heat, yang deficiency, dampness, blood stasis, yin deficiency and qi deficiency. With the disease progression, the frequencies of location factors of PLGC from high to low were stomach, spleen and liver, while those of nature factors were heat, yang deficiency, yin deficiency, qi stagnation, blood stasis, dampness, and qi deficiency. The distributions of location factors as well as nature factors were significantly different during the whole procedure of CG progression, CNAG, CAG and finally PLGC. Conclusion During the procedure of: CNAG turned into CAG and into PLGC in the end, the evolvement characteristic of “sthenia transforming into asthenia and appearing yin deficiency and blood stasis gradually” was found.
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