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主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 November 2015, Volume 38 Issue 11 Previous Issue    Next Issue
    Original Article
    Source tracing of triple energizers*
    ZHANG Tianxing, HE Juan
    2015, 38 (11):  725-728.  doi: 10.3969/j.issn.1006-2157.2015.11.001
    Abstract ( 438 )   PDF (1252KB) ( 934 )   Save
    According to Huangdi Neijing and Nanjing, the triple energizers (sanjiao), a TCM term, is considered and proved to be the collection of lots of crannies in human body from the aspects of its name, function, shape, characteristics and location. Specifically, sanjiao is composed of three wide crannies below the diaphragm and from which countless tiny crannies extended, that is to say, it is exactly a three-dimensional network performing ying and wei production, qi and blood transportation, water spreading, vital qi communication and original qi transportation. The three wide crannies mentioned above can be considered as the main body of san jiao existed, and the voids in the body is just the position of sanjiao. The paper also tries to explain the fououing issues: sanjiao with name but without form, the relationship between sanjiao and channel, syndrome differentiation of sanjiao.
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    Research Characteristics of TCM Literature and Preliminary Study of Academic Achievement of Professor Chaochen Qian
    PENG Ronghua
    2015, 38 (11):  732-734.  doi: 10.3969/j.issn.1006-2157.2015.11.003
    Abstract ( 467 )   PDF (1160KB) ( 702 )   Save
    Professor Chaochen Qian upholds the Qian-Jia School and the traditional linguistics inherited by Zhang-Huang-Lu, He introduces the ordinary exegesis to the classical study of Traditional Chinese Medicine (TCM) and has greatly boosted the development of exegetical study of TCM and the research of ancient TCM documents. His “HuangDi Nei Jing Tai Su”, which is a masterpiece in the history of “Tai Su” and even the research of ancient TCM documents, studies the “Tai Su” systematically and comprehensively from the aspect of text, phonology, exegesis, collation and textology. His academic achievements mainly reflect in: 1) inheriting the outstanding contribution of the idea of Taiyan Zhang to the edition studying of “Treatise on Febrile Diseases”; 2) studying the classical TCM from the aspect of the Qian-Jia School and the traditional linguistics inherited by Huanglu Zhang; 3) correcting the E words and wrong annotations in TCM by using text, phonology, and exegesis; 4) well-researching the version and rescuing the out-of-print book.
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    Chemotherapy-induced premature ovarian failure rats treated by TCM therapy of tonifying kidney-yin with bone marrow mesenchymal stem cells transplantation*
    QIN Jiajia, WU Qian, YANG Jing , LIANG Jiali
    2015, 38 (11):  735-739.  doi: 10.3969/j.issn.1006-2157.2015.11.004
    Abstract ( 396 )   PDF (1435KB) ( 662 )   Save
    Objective To explore the feasibility of Zuogui pill (ZGP), a traditional Chinese medicine formulated by TCM therapy of tonifying kidney-yin, with the therapy of bone marrow mesenchymal stem cells (BMSC) transplantation in premature ovarian failure (POF) induced by chemotherapy. Methods The rat model of POF was established by intraperitoneal injection of cyclophosphamide (cytoxan,CTX) for consecutive 14 d. All the PDF rats were divided into model group, BMSC transplantation (BMSCT) group and BMSCT combined with ZGP (BMSCT+ZGP) group, and the healthy young rats were included in control group. The levels of estradiol (E2), follicle-stimulating hormone (FSH) in peripheral blood were determined by using ELISA , the ovarian granulosa cell apoptosis were tested by Tunel assay, and the mRNA expressions of Bcl-2 Associated X (Bax) and B-cell lymphoma-2 (Bcl2) were examined by Western blot. Results After successful modeling, the level of E2 in peripheral blood in the model group was much lower than that in the control group, and the level of FSH in peripheral blood was much higher(both P<0.01). Compared with model group, the level of E2 increased gradually while FSH decreased guadually in both BMSCT group and BMSCT+ZGP group(P<0.01), and the changes of E2 and FSH were more obvious in BMSCT+ZGP group than those in BMSCT group. Tunel showed that the number of cells decreased in both BMSCT group and BMSCT+ZGP group, compared with model group, but there were no significant difference between the two treatment groups. The mRNA expressions of Bax were lower in both treatment groups than that of model group, and the significant decreasing was found in BMSCT+ZGP group compared with model group(P<0.05). The mRNA expressions of Bcl2 increased significantly after BMSCT and ZGP treatment compared with model group(P<0.01). Conclusion BMSCT combined with ZGP could improve ovarian function in POF rats induced by chemotherapy, and the effect was better than that of BMSCT only.
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    Effects of Naoluo Xintong decoction on mRNA expressions of 5-hydroxytryptamine, dopamine, norepinephrine and 5-hydroxyindoleacetic acid in corpus striatum tissues of MCAO rats*
    HE Ling, WEN Anhui, YAN Zhengyuan, HU Jianpeng, XU Wei, TAN Hui, WANG Jian
    2015, 38 (11):  740-744.  doi: 10.3969/j.issn.1006-2157.2015.11.005
    Abstract ( 436 )   PDF (1190KB) ( 594 )   Save
    Objective To study the mechanism of protective effect of Naoluo Xintong decoction(NLXTD), a traditional Chinese medicine compound, on cerebral ischemia-reperfusion injury in rats. Methods Altogether 100 male SD rats were randomly divided five groups( each n=20 ): sham-operated group, model group, premedication group, three-day-medication group and seven-day-medication group. After modeling, three-day-medication group was administered intragastrically (i.g.) NLXTD for consecutive three days, and the seven-day-medication group for seven days at the dose of 8.54 g/kg daily twice. The premedication group was treated with NLXTD of 8.54 g/kg daily twice for consecutive seven days before modeling .The model group and sham-operated group were treated with the distill water for seven days. Regional cerebral blood flow (rCBF) of corpus striatum of the side of cerebral infarction was measured by using laser Doppler imager (LDF). Then all the rats were sacrificed and the corpus striatum were dissected out from brain. Infarct volume was determined by using 2,3,5-triphenyltetrazolium chloride (TTC) staining, and the mRNA expressions of 5-hydroxytryptamine(5-HT), dopamine(DA), norepinephrine(NE) and 5-hydroxyindoleacetic acid(5-HIAA) in the corpus striatums were detected by qRT-PCR. Results Compared with the sham-operated group, the rats of the model group, with obvious cerebral ischemia, suffered more cerebral infarction volume(P<0.01),and the levels of mRNA expression of 5-HT,DA,NE and 5-HIAA in corpus striatum significantly decreased(P<0.01). Compared with the model group, the cerebral infarction volume of premedication group, three- and seven- day-medication group dramatically decreased by increasing the cerebral blood flow(P<0.01); the mRNA expressions of 5-HT, DA, NE and 5-HIAA increased significantly(P<0.01). Conclusion NLXTD could prevent and cure cerebral injury of MCAO rats by increasing the cerebral blood flow and decreasing the cerebral infarction volume to increase the mRNA expressions of monoamine transmitters of 5-HT, DA, NE and 5-HIAA of corpus striatum of rats.
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    Effects of Gehua Jiecheng decoction on regulation factors of cell cycle in ethanol-type HBV transgenic mice with hepatocellular carcinoma precancerous lesions*
    GUO Bin,TANG Dongxin,LONG Fengxi, LUO Li,HUANG Hui,WANG Dingxue,LI Jun,WANG Jinghui,YANG Zhu
    2015, 38 (11):  745-748.  doi: 10.3969/j.issn.1006-2157.2015.11.006
    Abstract ( 367 )   PDF (1180KB) ( 563 )   Save
    Objective To study the effect and mechanism of Gehua Jiecheng decoction (GHJCD), a traditional Chinese herbal medicine compound, on cell cycle regulation factors-Cyclin D1, CDK4 and p27 KIP1 in HBV transgenic mice with hepatocellular carcinoma (HCC) precancerous lesions induced by alcohol. Methods Altogether 24 HBV transgenic mice were randomly divided into normal group, model group and GHJCD group(each n = 8). All the mice were sacrificed at the end of the 22th week, then their livers were dissected. Pathohistological changes of liver were observed by using HE staining, and the expression of CyclinD1, CDK4 and p27KIP1 protein in hepatic tissue were detected by using immunohistochemistrical methods. Results Compared with the normal group, the positive expressions of CyclinD1 and CDK4 increased and that of p27KIP1 decreased significantly (P<0.05) in the model group. Compared with the model group, restoration of injured liver tissue was occurred in GHJCD group, and the position expressions of CyclinD1 and CDK4 decreased significantly (P<0.05) and the expression of p27KIP1 increased significantly (P<0.05). Conclusion The protective effects of GHJCD on liver injures and HCC precancerous lesions took effects by downregulation of genes of CyclinD1 and CDK4 and upregulation of gene of p27KIP1.
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    Effects of TCM therapy method of yang-warming and fluid retention-resolving on expression of aquaporin-2 in kidney of rats with congestive heart failure*
    XU Jianhu,ZHANG Qi,YANG Ziqing,LUO Chiqiong,LI Leibing,REN Xiaotong,LI Linxian, XU Lu, XIAO Hua
    2015, 38 (11):  749-752.  doi: 10.3969/j.issn.1006-2157.2015.11.007
    Abstract ( 392 )   PDF (1116KB) ( 492 )   Save
    Objective To explore the potential mechanism of eliminating fluid-retention by yang-warming and fluid retention-resolving method. Methods Rat model of congestive heart failure (CHF) was established by intraperitoneal injection of adriamycin. After modeling, the CHF rats were randomly divided into model group, group of yang-warming and fluid retention-resolving formula (YWFRR group), and group of yang-warming and fluid retention-resolving formula minus cinnamon twig (YWFRR-CT group). The rats of YWFRR group were intragastrically administered (i.g.)YWFRR at the dose of 12 g/kg once daily for consecutive four weeks, and those of YWFRR-CT were i.g. YWFRR-CT at the dose of 10 g/kg once daily for four weeks, at the same time, the rats of model group and blank group took no medication treatment. Then the serum level of brain natriuretic peptide (BNP) and protein expression of aquaporin-2 (AQP2) in renal tissue were determined. Results Compared with the blank group , the serum content of BNP in model group increased significantly and the expression of AQP2 in renal tissue decreased significantly (P<0.05 or P<0.01). The contents of serum BNP were both lower in YWFRR group and YWFRR-CT group than that of model group, and the expression of AQP2 higher. Conclusion The method of yang-warming and fluid retention-resolving could decrease the serum content of BNP and upregulate the expression of renal AQP2 of CHF rats.
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    Comparison of day and night nonlinear indexes among syndromes differentiationed by excess and deficiency: a study of 243 patients with coronary heart disease*
    YANG Yang, LI Fangjie,LI Xia,YANG Xinchun, ZENG Hui, GUO Xiaoyu, DAI Yuelong
    2015, 38 (11):  753-755.  doi: 10.3969/j.issn.1006-2157.2015.11.008
    Abstract ( 406 )   PDF (1105KB) ( 514 )   Save
    Objective To observe the day and night nonlinear indexes in patients with coronary heart disease(CHD)of excess syndrome, deficiency syndrome and syndrome of intermingled deficiency and excess (mingled syndrome), so as to explore the nonlinear characteristics existed objectively in TCM syndromes. Methods Based on the TCM principles of syndrome differentiation, 243 patients were divided into excess syndrome group(excess group, n=44), mingled syndrome group(mingled group, n=148)and deficiency syndrome group(deficiency group, n=51). Three nonlinear indexes of complexity, mean value of correlation dimension and mean value of approximate entropy were calculated based on the data picked up from 24 h dynamic electrocardiogram(Holter)at the six time intervals: 0∶00 to 1∶00, 4∶00 to 5∶00, 8∶00 to 9∶00, 12∶00 to 13∶00, 16∶00 to 17∶00 and 20∶00 to 21∶00. Results The values of the three nonlinear indexes had a feature in common: the highest in excess group and the lowest in deficiency group. Conclusion The differences of three nonlinear indexes among the syndromes of excess and deficiency presented the differences of the nonlinear characteristics and the functional status of autonomic nerves.
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    Distribution of TCM syndrome elements at active stage and at stationary stage and their correlation with serum homocysteine level: a study of 715 patients with hepatitis cirrhosis*
    HOU Shuaiying, WANG Tianfang, XUE Xiaolin, WU Xiuyan, ZHAO Lihong, LI Yonggang, LI Xin, LI Ning, REN Hong,LIU Lulu,ZHANG Xiaona, LUO Qingxiang,ZHANG Jiayuan
    2015, 38 (11):  756-761.  doi: 10.3969/j.issn.1006-2157.2015.11.009
    Abstract ( 409 )   PDF (1130KB) ( 492 )   Save
    Objective To explore the characteristics of distribution of TCM syndrome elements of disease nature between active stage and stationary stage of patients with hepatitis cirrhosis, and to study the correlation between the TCM syndrome elements and serum level of homocysteine (Hcy). Methods By using Information Collection Form of Hepatitis Cirrhosis drafted by our research team, a national multicenter and cross-sectional epidemiological survey was conducted to collect the general condition, symptoms, and blood samples from which the serum Hcy levels were obtained. In accordance with Standard of Hepatitis Cirrhosis Syndrome Elements Differentiation, the TCM syndrome elements of nature of the patients were determined. Then the correlation of the TCM syndrome elements and the serum levels of Hcy was investigated at active stage and stationary stage. Results Altogether 715 patients were included. The frequency of all syndrome elements in patients of active stage were higher than those in patients of stationary phase, in which the element of blood stasis, yin deficiency, qi deficiency, yang deficiency and water retention showed statistical differences (P<0.05). The serum level of Hcy in patients of active stage was higher significantly than that of stationary stage (P<0.05). The Hcy level of patients with yin deficiency pattern was lower than that of patients without yin deficiency pattern, the same as element of damp heat, qi stagnation and yang deficiency; however, the situations of element of blood stasis, qi deficiency and water retention were quite the reverse. In the patients of stationary stage, the serum levels of Hcy showed significant difference between qi stagnation group and non qi stagnation group (P<0.05). In the patients of active stage, the levels of Hcy showed difference between yin deficiency group and non yin deficiency group, as well as the element of qi deficiency (P<0.05). Conclusion The frequency of TCM syndrome elements and the serum Hcy level in patients of active stage higher than those of patients of stationary stage, reflected the degree of hepatic inflammation and severity of disease. That the correlation between the Hcy level and the TCM syndrome elements of nature could provide the evidence for pathological basis and standardization study of TCM syndrome elements in patients with hepatitis cirrhosis.
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    Evolvement characteristics of TCM syndrome types of chronic gastritis: a clinical study of 592 patients*
    SU Zeqi,LI Peicai,GUO Qiang,ZHU Chenchen,WANG Xiaodi,CHEN Liang,LIU Fusheng,LIU Ting,ZHANG Yin,WANG Longhua,DING Xia
    2015, 38 (11):  762-766.  doi: 10.3969/j.issn.1006-2157.2015.11.010
    Abstract ( 448 )   PDF (1125KB) ( 583 )   Save
    Objective To explore the evolvement rule of TCM syndrome types of the transformation of chronic gastritis (CG) : from chronic non-atrophic gastritis (CNAG) , chronic atrophic gastritis (CAG) to precancerous lesions of gastric carcinoma (PLGC). Methods Based on gastroscopy and gastrobiopsy, altogether 592 patients included from three hospitals affiliated to Beijing University of Chinese Medicine Dongzhimen Hospital, (Dongfang Hospital and Third affiliated Hospital) and Wangjing hospital of China Academy of Chinese Medical Sciences from September 2013 to February 2014, were diagnosed with CNAG (338 cases), CAG (134 cases) and PLGC (120 cases). By using Epidata 3.1 the database was established, then principal component analysis, factor analysis and Chi-square test were conducted by using software SPSS 17.0. Results There were nine common syndrome types in CNAG, and the three leading ones were syndrome of incoordination between spleen and stomach, syndrome of heat-stagnation in liver and stomach, syndrome of incoordination between liver and stomach. There were ten syndrome types in CAG, and the highest frequency was syndrome of incoordination between liver and stomach, then syndrome of static blood in stomach collaterals and syndrome of deficient cold of spleen and stomach. The highest frequency of three syndrome of ten in PLGC were syndrome of yin deficiency in stomach, syndrome of yang deficiency in stomach and syndrome of static blood in stomach collaterals. The frequencies of location factors of CNAG from high to low were stomach, liver and spleen, the same as those of CAG; the frequencies of nature factors from high to low were qi stagnation, heat, qi deficiency, dampness and yang deficiency, which were some different from those of CAG being qi stagnation, heat, yang deficiency, dampness, blood stasis, yin deficiency and qi deficiency. With the disease progression, the frequencies of location factors of PLGC from high to low were stomach, spleen and liver, while those of nature factors were heat, yang deficiency, yin deficiency, qi stagnation, blood stasis, dampness, and qi deficiency. The distributions of location factors as well as nature factors were significantly different during the whole procedure of CG progression, CNAG, CAG and finally PLGC. Conclusion During the procedure of: CNAG turned into CAG and into PLGC in the end, the evolvement characteristic of “sthenia transforming into asthenia and appearing yin deficiency and blood stasis gradually” was found.
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    Effect of Chinese medicine compound of cooling blood and detoxification on Th1/Th2 balance of psoriasis vulgaris patients with TCM syndrome of blood heat*
    SUN Shaoxin,XU Jie,ZHOU Yuefei,DONG Bin,JIN Qinshuo,QU Xing,DUAN Xingwu,LI Lingling
    2015, 38 (11):  767-771.  doi: 10.3969/j.issn.1006-2157.2015.11.011
    Abstract ( 481 )   PDF (1132KB) ( 661 )   Save
    Objective To investigate Xiaoyin Jiedu formula (XYJDF), a Chinese medicine compound formulated by TCM method of cooling blood and detoxification, on peripheral T cell subset and the balance of type 1 helper T cells (Th1) and type 2 helper T cells (Th2) of psoriasis vulgaris (PV)patients with syndrome of blood heat, and to try to explore the potential immunological mechanism of XYJDF on treatment of PV at progression stage and stationary stage. Methods 80 patients (progression stage and stationary stage) were randomly divided into treatment group and control group, each 40 cases. The patients of the treatment group took orally XYJDF and those of the control group took orally XiaoYin capsule for consecutive eight weeks. Psoriasis Area and Severity Index score (PASI) and peripheral CD3+, CD4+, CD8+, and the balances of CD4+ / CD8 + and Th1 / Th2 were recorded before and after treatment. Results After eight-week-treatment, PASI scores decreased and the contents of CD4+ increased both in two groups(P<0.05), but only in the treatment group the content of CD8+and Thl decreased(P<0.05). Conclusion XYJDF could effectively reduce PASI score of the psoriasis vulgaris patients with syndrome of blood heat by the way of regulating patient blood contents CD3+, CD4+ and CD8+, as well as the balance of CD4+ / CD8+ and Th1 / Th2.
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    Effects of method of nourishing heart and spleen on estrogen, progestin and TCM syndrome score in patients with postpartum depression*
    WANG Dan, ZHAO Ruizhen, LI Xiaoli, XU Fang, TANG Qisheng
    2015, 38 (11):  772-776.  doi: 10.3969/j.issn.1006-2157.2015.11.012
    Abstract ( 422 )   PDF (1185KB) ( 664 )   Save
    Objective To evaluate the efficacy and safety of Shenqi Jieyu formula (SQJYF), a Chinese medicine compound formulated by the method of nourishing heart and spleen, on patients with postpartum depression (PD), so as to provide more evidence for Chinese medication treatment no depression. Methods Altogether 60 PD patients with the syndrome of deficiency of both heart and spleen from the third affiliated hospital and three communities were included, who were randomly divided into treatment group and placebo group (n=30 each). The patients of the treatment group were taken orally SQJYF one dose daily, while patients of the placebo group were taken starch particles at the same dose for consecutive six weeks. The efficacy was assessed by using TCM Depression Scale as well as measuring serum estrogen, progestin before treatment, at the first week, second week, fourth week and sixth week of treatment. Results The total effective rate of treatment group was 86.67%, while 73.33% of the placebo group; the clinical control rate of treatment group was 26.67% to 10.00% in the placebo group. There was significant difference in decreasing rate of TCM score between the two groups at the second week, fourth week and sixth week after treatment (P<0.05). The serum levels of estrogen both increased in two groups. There were significant difference between before and after treatment of each group, and the serum estrogen in treatment group was higher than that in placebo group(P<0.05). The serum levels of progestin both decreased in two groups. After six-week-treatment, the levels showed significant difference between before and after treat(P<0.05), while no difference was proved between the two groups(P> 0.05). Conclusion SQJYF had the advantages of rapid onset and less side effects by decreasing TCM syndrome scores and the serum level of estrogen, and increasing the serum level of progestin, on PD depression patients with the syndrome of deficiency of both heart and spleen.
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    Clinical efficacy of TCM formula of replenishing qi and resolving phlegm and dispelling stasis on patients with stable chronic obstructive pulmonary disease*
    WANG Wei,WU Haibin,WANG Qi,ZHANG Yongsheng,HAN Feixiang,LI Jinting
    2015, 38 (11):  777-780.  doi: 10.3969/j.issn.1006-2157.2015.11.013
    Abstract ( 445 )   PDF (1120KB) ( 1031 )   Save
    Objective To evaluate the clinical efficacy of qi-replenishing, phlegm-resolving and stasis-diapelling formula, a Chinese compound medicine, on the patients of stable stage with chronic obstructive pulmonary disease (COPD). Methods Altogether 51 COPD patients with TCM syndrome of deficiency of lung qi, spleen qi, kidney qi and phlegm-stasis obstruction were randomly divided into Chinese medication group (n=26) and control group (n=25) .The patients of the control group were treated with only routine Western medication, while those of the Chinese medication group were treated with the routine Western medication combined with TCM formula for consecutive four months. Results There were significant differences of forced expiratory volume in one second (FEV1) , changes of symptom scores and COPD assessment test (CAT) scores between after treatment and before treatment in Chinese medication group(P<0.05). Compared with control group, all the indexes mentioned above showed statistical differences in Chinese medication group(P<0.05). Conclusion The clinical efficacy and safety of Chinese formula were proved by the means of comparison of FEV1, symptom scores and CAT scores between Chinese medication group and control group.
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    Combination of syndrome factors: 268 idiopathic fatigue cases study*
    WANG Yaowei, DU Jianan, CHEN Zhiwei, ZHONG Jingbai
    2015, 38 (11):  781-784.  doi: 10.3969/j.issn.1006-2157.2015.11.014
    Abstract ( 429 )   PDF (1108KB) ( 471 )   Save
    Objective To observe the distribution rules of syndrome factors and common syndromes of patients with idiopathic fatigue(IF). Methods 268 cases with IF were collected in outpatient, and the distribution and combination of syndrome factors were analyzed. Results Altogether eight syndrome factors were found, and the frequency from high to low was listed as qi stagnation, qi deficiency, fire heat, yin deficiency, blood deficiency, yang deficiency, phlegm and blood stasis. The top three combination syndromes were syndrome of qi depression transforming into fire with qi deficiency (n=162), syndrome of qi stagnation with qi deficiency (n=84) and syndrome of qi-yin deficiency with qi depression transforming into fire (n=83). The rest combination types were listed as syndrome of qi depression transforming into fire with qi deficiency-caused phlegm, syndrome of phlegm-heat stasis with qi deficiency, syndrome of phlegm stasis and qi stagnation of qi transforming into fire , syndrome of qi stagnation with qi / yang deficiency, syndrome of qi depression transforming into fire with qi deficiency and blood stasis. Conclusion In patients with IF, qi stagnation, qi deficiency and fire were the common syndrome factors, and the common syndromes were syndrome of qi depression transforming into fire heat with qi deficiency and syndrome of qi stagnation with qi deficiency.
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    Journal of Beijing University of Traditional Chinese Medicine and Education of Chinese Medicine: establishment of the online database and the academic analysis of their previous articles*
    ZHANG Weiwei, ZHANG Chi, YANG Wenjun, BAI Jin, YOU Haiyan
    2015, 38 (11):  785-788.  doi: 10.3969/j.issn.1006-2157.2015.11.015
    Abstract ( 398 )   PDF (1116KB) ( 389 )   Save
    Objective To provide the full-service of two journal websites : http://xb.bucm.edu.cn (Journal of Beijing University of Traditional Chinese Medicine, JBUTCM)and http://zyjy.bucm.edu.cn (Education of Chinese Medicine, ECM) for the authors and readers online searching conveniently and facilitatively , and to enhance the information exchange by optimizing the management of the data and maximizing the value of the data. Methods All the previous articles of JBUTCM and ECM collected, reorganized and digitalized from the first issue year to 2009 were posted online.Results Altogether 198 issues and 5 227 articles published in JBUTCM since the first issue year 1959 to 2009 (discontinued from 1960 to 1979), which reflected basic research and clinical study of Chinese medicine. ECM was established in 1982, and published 175 volumes and 4 758 articles aimed to the study of educating and teaching of Chinese medicine. Conclusion After the online databases were completed, the two journal websites should be updated and maintained. By recording holistically the achievements and dynamics of the academic research in various fields of Chinese traditional medicine, JBUTCM and ECM provided innovative prospect for future research and encouraged further study for Chinese medicine.
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    Electro-acupuncturing at “Baihui” point and “Zusanli” point on beha- vior and mRNA expression of intestinal NK1 receptor in rats with irritable bowel syndrome*
    ZHAO Yafang,GUO Mengwei,WANG Shun,YANG Shuai,FENG Xiaoxiao,REN Xiaoxuan
    2015, 38 (11):  789-792.  doi: 10.3969/j.issn.1006-2157.2015.11.016
    Abstract ( 383 )   PDF (1168KB) ( 588 )   Save
    Objective To observe the effects of electro-acupuncturing (EA) at “Baihui”(DU20)and “Zusanli” (ST36) on the visceral sensitivity and emotional and psychological behavior of the irritable bowel syndrome (IBS) model rats, and to explore the double adjustment of electro-acupuncture on chronic visceral pain with emotional and psychological dysfunction. Methods Wistar immature rats were randomly divided into normal group, model group and electro-acupuncture group. The IBS model was induced by mechanical colorectal irritation of acetic acid combined with maternal separation in the postnatal period. Rats of normal group and model group underwent no intervention while those of electro-acupuncture group were needled at “Baihui” and “Zusanli” every other day for ten days. The visceral sensitivity was evaluated and the open-filed test was used, and the mRNA of neurokinin-1(NK1) receptor was detected by using RT-PCR. Results The treatment of acupuncture reduced significanty the visceral sensitivity, crossing activity and vertical activity in open field test, and the mRNA expression of NK1. Conclusion The double adjustment of electro-acupuncturing at “Baihui” and “Zusanli” on chornic visceral sensitivity with emotional and psychological dysfunction was proved.
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